Multiple Myeloma Exam Questions With 100%
Correct Answers
plasma cells
bone marrow
Multiple myeloma is malignant neoplasm of _______ ______ that accumulate in the ______
_________ which causes bone destruction and marrow failure.
smoldering
Term used for asymptomatic myeloma
MGUS
Which disorder is characterized by clonal plasma cells < 10 % in bone marrow?
>3g
Smoldering MM has > 10% clonal plasma cells in bone marrow and present with what level of M
protein?
Multiple Myleoma
Characteristics of
> 10 % in bone marrow
M protein is present in the Serum and urine
End organ damage is present
bone pain and fractures
What are two hallmark clinical presenting signs of Multiple Myeloma?
SPEP (serum protein electrophoreses)
(gamma - M-spike)
Which test is a diagnostic "tell-tale" sign of Multiple Myeloma?
Absence of symptoms
M protein present
What is the easy way of defining Smoldering Myeloma?
CRAB
(Calcium > 11.5 g/dL,
Renal creatinine > 2 mg/dL,
Anemia < 10 g/dl or 2 g/dl lower than normal,
Bone disease -- lytic or osteopenic)
What is the easy way to define Active multiple myeloma?
, Stage 1
Prognosis: International Staging System (ISS)
-serum Beta-2 microglobulin < 3.5 mg/L
-serum albumin > 3.5 g/dL
median overal survival time of 62 months
> 5.5 mg/L
What level of Serum Beta-2 micro globulin indicated Stage III Multiple myeloma -- 29 month overall
survival?
3-6 months
How often should you observe Smoldering Multiple myeloma?
bortezomib (Velcade)
What agent is the main stay for First-line induction treatment for transplant eligible patients?
melphalan
Which agent should not be used in INDUCTION of transplant eligible patients?
IV
SQ
What routes is bortezomib administered?
2C19
3A4
2C19
bortezomib is a major substrate of _________ and _______ and a moderated inhibitor of ________.
thalidomide (Thalomid)
lenalidomide (Revlimid)
pomalidomide (Pomalyst)
Which agents are immunomodulators -- IMiDs? (3)
immunomodulatory
antiangiogenesis
antineoplastic
What are the common mechanisms of action for immunomodulators? (3)
thalidomide
Correct Answers
plasma cells
bone marrow
Multiple myeloma is malignant neoplasm of _______ ______ that accumulate in the ______
_________ which causes bone destruction and marrow failure.
smoldering
Term used for asymptomatic myeloma
MGUS
Which disorder is characterized by clonal plasma cells < 10 % in bone marrow?
>3g
Smoldering MM has > 10% clonal plasma cells in bone marrow and present with what level of M
protein?
Multiple Myleoma
Characteristics of
> 10 % in bone marrow
M protein is present in the Serum and urine
End organ damage is present
bone pain and fractures
What are two hallmark clinical presenting signs of Multiple Myeloma?
SPEP (serum protein electrophoreses)
(gamma - M-spike)
Which test is a diagnostic "tell-tale" sign of Multiple Myeloma?
Absence of symptoms
M protein present
What is the easy way of defining Smoldering Myeloma?
CRAB
(Calcium > 11.5 g/dL,
Renal creatinine > 2 mg/dL,
Anemia < 10 g/dl or 2 g/dl lower than normal,
Bone disease -- lytic or osteopenic)
What is the easy way to define Active multiple myeloma?
, Stage 1
Prognosis: International Staging System (ISS)
-serum Beta-2 microglobulin < 3.5 mg/L
-serum albumin > 3.5 g/dL
median overal survival time of 62 months
> 5.5 mg/L
What level of Serum Beta-2 micro globulin indicated Stage III Multiple myeloma -- 29 month overall
survival?
3-6 months
How often should you observe Smoldering Multiple myeloma?
bortezomib (Velcade)
What agent is the main stay for First-line induction treatment for transplant eligible patients?
melphalan
Which agent should not be used in INDUCTION of transplant eligible patients?
IV
SQ
What routes is bortezomib administered?
2C19
3A4
2C19
bortezomib is a major substrate of _________ and _______ and a moderated inhibitor of ________.
thalidomide (Thalomid)
lenalidomide (Revlimid)
pomalidomide (Pomalyst)
Which agents are immunomodulators -- IMiDs? (3)
immunomodulatory
antiangiogenesis
antineoplastic
What are the common mechanisms of action for immunomodulators? (3)
thalidomide
