MARYVILLE NURS 660 EXAM 4
2024 -2025
Which medication is contraindicated with liver impairment? - correct answer✔✔ Atomoxine (Straterra)
What is one of the birth defects associated with Litihum? - correct answer✔✔ Ebstein's anomaly
Which SSRI drug causes cardiovascular malformations in the first trimester of pregnancy? - correct
answer✔✔ Paroxetine (Paxil)
Mechanism of action of a stimulant for ADHD Methylphenidate and amphetamine? - correct answer✔✔
increases the intrasynaptic levels of both dopamine and norepinephrine
What causes nicotine withdrawal symptoms? - correct answer✔✔ Nicotine alpha 4 beta 2 post synaptic
receptors desensitizes receptors which leads to addiction. Re-sensitization of the nicotine receptors
leads to withdrawal
A patient diagnosed with ADHD can't stay focused or solve work-related problems difficulty maintaining
attention sustained and problem-solving. What area of the brain is involved? - correct answer✔✔ Dorsal
lateral prefontal cortex (CTSC loop)
What part of the brain is associated with selective attention? - correct answer✔✔ Dorsal anterior
singlunate
What part of the brain is associated with hyperactivity? - correct answer✔✔ Prefrontal motor cortex
What part of the brain is associated with impulsivity? - correct answer✔✔ Orbitofrontal cortex
, Atomoxetine (Strattera) lacks abuse potential because of what - correct answer✔✔ increases dopamine
in the dorsal prefrontal cortex and not in the nucleus accumbens
What fetal malformation does valproate cause? - correct answer✔✔ Spina bifida
What region of the brain is hypothesized to cause impulsivity? - correct answer✔✔ ventral striatum
What region of the brain controls compulsivity? - correct answer✔✔ Dorsal striatum
What is the MOA of atomoxetine (Strattera)? - correct answer✔✔ Selective Norepinephrine Reuptake
Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline and may also increase dopamine in
profrontal cortex • Blocks norepinephrine reuptake pumps, also known as norepinephrine transporters
•
Amaloid precursor protein is first cleaved by what enzyme - correct answer✔✔ Alpha-secretase
What does paroxetine do to Straterra in the body? - correct answer✔✔ increases the effect of the drug
in the body
If a patient is taking paroxetine and starts Straterra what should change about the Straterra dose? -
correct answer✔✔ The dose should be decreased
An Alzheimer's patient has been taking 4mg of rivastigmine what side effects might you anticipate and
why? - correct answer✔✔ GI side effects; inhibits peripheral uptake of ACH and butyrycholine
Which neurotransmitters lead to eurphoria and abuse in a patient with marijuana abuse and ADHD. -
correct answer✔✔ Pulsatile delivery of stimulants can cause a frequent and rapid delivery amplifying
phasic firing of NE and DA. Phasic firing is associated with reward, euphoria, and abuse
What does alcohol do to the CYP 450 system? - correct answer✔✔ lowers the rate of drug metabolism
2024 -2025
Which medication is contraindicated with liver impairment? - correct answer✔✔ Atomoxine (Straterra)
What is one of the birth defects associated with Litihum? - correct answer✔✔ Ebstein's anomaly
Which SSRI drug causes cardiovascular malformations in the first trimester of pregnancy? - correct
answer✔✔ Paroxetine (Paxil)
Mechanism of action of a stimulant for ADHD Methylphenidate and amphetamine? - correct answer✔✔
increases the intrasynaptic levels of both dopamine and norepinephrine
What causes nicotine withdrawal symptoms? - correct answer✔✔ Nicotine alpha 4 beta 2 post synaptic
receptors desensitizes receptors which leads to addiction. Re-sensitization of the nicotine receptors
leads to withdrawal
A patient diagnosed with ADHD can't stay focused or solve work-related problems difficulty maintaining
attention sustained and problem-solving. What area of the brain is involved? - correct answer✔✔ Dorsal
lateral prefontal cortex (CTSC loop)
What part of the brain is associated with selective attention? - correct answer✔✔ Dorsal anterior
singlunate
What part of the brain is associated with hyperactivity? - correct answer✔✔ Prefrontal motor cortex
What part of the brain is associated with impulsivity? - correct answer✔✔ Orbitofrontal cortex
, Atomoxetine (Strattera) lacks abuse potential because of what - correct answer✔✔ increases dopamine
in the dorsal prefrontal cortex and not in the nucleus accumbens
What fetal malformation does valproate cause? - correct answer✔✔ Spina bifida
What region of the brain is hypothesized to cause impulsivity? - correct answer✔✔ ventral striatum
What region of the brain controls compulsivity? - correct answer✔✔ Dorsal striatum
What is the MOA of atomoxetine (Strattera)? - correct answer✔✔ Selective Norepinephrine Reuptake
Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline and may also increase dopamine in
profrontal cortex • Blocks norepinephrine reuptake pumps, also known as norepinephrine transporters
•
Amaloid precursor protein is first cleaved by what enzyme - correct answer✔✔ Alpha-secretase
What does paroxetine do to Straterra in the body? - correct answer✔✔ increases the effect of the drug
in the body
If a patient is taking paroxetine and starts Straterra what should change about the Straterra dose? -
correct answer✔✔ The dose should be decreased
An Alzheimer's patient has been taking 4mg of rivastigmine what side effects might you anticipate and
why? - correct answer✔✔ GI side effects; inhibits peripheral uptake of ACH and butyrycholine
Which neurotransmitters lead to eurphoria and abuse in a patient with marijuana abuse and ADHD. -
correct answer✔✔ Pulsatile delivery of stimulants can cause a frequent and rapid delivery amplifying
phasic firing of NE and DA. Phasic firing is associated with reward, euphoria, and abuse
What does alcohol do to the CYP 450 system? - correct answer✔✔ lowers the rate of drug metabolism
