PRE-NAPLEX EXAM Questions with 100%
Correct Answers
How do you calculate RRR?
You have these values:
Zoledronic acid (risk of fracture): 8.6%
Placebo (risk of fracture): 13.9%
1) Calculate the RR (% Tx/% Control)
8.6%/13.9% = 0.6187
2) Calculate RRR: (1 - RR)
1 - 0.6187 = 0.38
RRR: 38%
Zoledronic Acid treated patients where 38% less likely to have a fracture than placebo treated
patients.
You have a case: The primary endpoint for a fracture was lower with Zoledronic acid compared to
placebo (8.6% vs 13.9% respectively); p=0.001; RR= 0.62 [95% CI, 0.5 to 0.84]
What probability does the p-value tell you?
The p-value tells you that the probability of rejecting a true null hypothesis is 0.1%
RxPrep: When p-value is < 0.001 and alpha is 0.05:
99.9% probability (confidence) that the conclusion is correct; less than 0.1% chance it's not.
NOT SURE OF THIS DAMN QUESTION.
What does Intention to Treat tell you?
It includes data for ALL patients originally allocated to each treatment group (active and control) even
if the patient did not complete the trial according to the study protocol (ex. non-compliance, protocol
deviations, study withdrawal)
You have a study with the mean age of 75 (SD +/- 10).
What percentage describes the proportion of study subjects between 65 to 85 years of age in this
study?
if it forms a "gaussian" or "normal" curve
68% of values fall within 1 SD (65 to 85)
95% of values fall within 2 SD (55 to 95)
You have a patient on the below orders:
Morphine 10mg IV/Hr
Morphine 0.5mg IV Q 20 min prn via PCA
if they get the max amount of doses of PCA, how many mg of morphine will they receive over 12
hours?
138 mg of morphine
10mg x 12 = 120mg
12hr x (60min/hr) x (0.5mg/20 min) = 18mg
120 + 18 = 138mg
, How would you educate Mr. Blaine on using his peak flow meter?
the measurement takes into account the patient's height, gender, & age
Patients should measure their personal best by taking peak flow readings BID (AM + PM) for 2-3
weeks. The highest reading that occurs most frequently is their personal best
TECHNIQUE:
use QAM upon awakening before the use of asthma meds
Stand up straight, exhale comfortably
Blow out as hard and as fast as possible. Write down PB
ZONES:
green zone: (> 80-100% of personal best) - CLEAR!
yellow zone:(50-80% of personal best) - "caution" pt intervention required based on "action plan"
RED ZONE (<50% personal best): "MEDICAL ALERT" --> ED.
What vaccines are recommended in patients with Sickle Cell Disease?
Routine childhood series:
1. Haemophilus Influenzae type B (Hib)
2. Pneumococcal conjugate (PCV13, Prevnar)
Additional vaccines due to functional asplenia:
1. Meningococcal conjugate series plus routine boosters
2. Meningococcal serogroup B (Bexsero, Trumeba)"
3. Pnuemococcal polysaccharide (PPSV23, Pneumovax 23)""
4. Pnuemococcal conjugate (PCV13, Prevnar) x 1 in ANY patient > 6 y.o. of age if never recd as part of
routine childhood
": at age > 10 y.o.
"": at age > 2 y.o, booster 5 years later and at age > 65.
remember you don't want to give pnuemovax before 2 y.o. due to antibodies - they will not produce a
good response.
Describe Sickle Cell Anemia
Group of inherited RBC disorders resulting from a genetic mutation in the genes that encode
hemoglobin
RBCs contain abnormal hemoglobin or HgbS (sickle hemoglobin)
What are dietary/natural supplements that help with insomnia?
Valerian
Melatonin
Drinking chamomile tea in the evening to feel calmer can help some patients with insomnia
What is the MOA of Questran?
inhibit bile acid absorption
Questran = Cholestyramine
Used for Dyslipidemia
Describe the handling of Zarxio
Store in Refrigerator
Correct Answers
How do you calculate RRR?
You have these values:
Zoledronic acid (risk of fracture): 8.6%
Placebo (risk of fracture): 13.9%
1) Calculate the RR (% Tx/% Control)
8.6%/13.9% = 0.6187
2) Calculate RRR: (1 - RR)
1 - 0.6187 = 0.38
RRR: 38%
Zoledronic Acid treated patients where 38% less likely to have a fracture than placebo treated
patients.
You have a case: The primary endpoint for a fracture was lower with Zoledronic acid compared to
placebo (8.6% vs 13.9% respectively); p=0.001; RR= 0.62 [95% CI, 0.5 to 0.84]
What probability does the p-value tell you?
The p-value tells you that the probability of rejecting a true null hypothesis is 0.1%
RxPrep: When p-value is < 0.001 and alpha is 0.05:
99.9% probability (confidence) that the conclusion is correct; less than 0.1% chance it's not.
NOT SURE OF THIS DAMN QUESTION.
What does Intention to Treat tell you?
It includes data for ALL patients originally allocated to each treatment group (active and control) even
if the patient did not complete the trial according to the study protocol (ex. non-compliance, protocol
deviations, study withdrawal)
You have a study with the mean age of 75 (SD +/- 10).
What percentage describes the proportion of study subjects between 65 to 85 years of age in this
study?
if it forms a "gaussian" or "normal" curve
68% of values fall within 1 SD (65 to 85)
95% of values fall within 2 SD (55 to 95)
You have a patient on the below orders:
Morphine 10mg IV/Hr
Morphine 0.5mg IV Q 20 min prn via PCA
if they get the max amount of doses of PCA, how many mg of morphine will they receive over 12
hours?
138 mg of morphine
10mg x 12 = 120mg
12hr x (60min/hr) x (0.5mg/20 min) = 18mg
120 + 18 = 138mg
, How would you educate Mr. Blaine on using his peak flow meter?
the measurement takes into account the patient's height, gender, & age
Patients should measure their personal best by taking peak flow readings BID (AM + PM) for 2-3
weeks. The highest reading that occurs most frequently is their personal best
TECHNIQUE:
use QAM upon awakening before the use of asthma meds
Stand up straight, exhale comfortably
Blow out as hard and as fast as possible. Write down PB
ZONES:
green zone: (> 80-100% of personal best) - CLEAR!
yellow zone:(50-80% of personal best) - "caution" pt intervention required based on "action plan"
RED ZONE (<50% personal best): "MEDICAL ALERT" --> ED.
What vaccines are recommended in patients with Sickle Cell Disease?
Routine childhood series:
1. Haemophilus Influenzae type B (Hib)
2. Pneumococcal conjugate (PCV13, Prevnar)
Additional vaccines due to functional asplenia:
1. Meningococcal conjugate series plus routine boosters
2. Meningococcal serogroup B (Bexsero, Trumeba)"
3. Pnuemococcal polysaccharide (PPSV23, Pneumovax 23)""
4. Pnuemococcal conjugate (PCV13, Prevnar) x 1 in ANY patient > 6 y.o. of age if never recd as part of
routine childhood
": at age > 10 y.o.
"": at age > 2 y.o, booster 5 years later and at age > 65.
remember you don't want to give pnuemovax before 2 y.o. due to antibodies - they will not produce a
good response.
Describe Sickle Cell Anemia
Group of inherited RBC disorders resulting from a genetic mutation in the genes that encode
hemoglobin
RBCs contain abnormal hemoglobin or HgbS (sickle hemoglobin)
What are dietary/natural supplements that help with insomnia?
Valerian
Melatonin
Drinking chamomile tea in the evening to feel calmer can help some patients with insomnia
What is the MOA of Questran?
inhibit bile acid absorption
Questran = Cholestyramine
Used for Dyslipidemia
Describe the handling of Zarxio
Store in Refrigerator
