The COMPLEMENTARY SYSTEM
>
-
Complement proteins -
nur ne num
:
made cells
group of plasma proteins by LIVER mainly partially by
-
-> immune
. ,
present
Blood lymph extracellulalfluid
&
- in
-
"complement , destruction
of pathogen
so
> 30
-
-mostly proteolytic enzymes -
INACTIVE
↓ Paleoge a => COMPLEMENT
ACTIVATION
-
involved
in
destruction
/causes
ACTIVE
&
=> COMPLEMENT FIXATION >
-
diagnosis of infectious ① ↑
auto immune diseases
. phagocytosis
②
inflammation
③
Cytolysis
COMPLEMENT ACTIVATION
pathways
I
Antibody independent , >
Ab dependent
[INNATE IS] ⑭ [ACQUIRED IS]
Act as a
bridge
W ↓ V
ALTERNATIVE MANNOSS
PATHWAY
CLASSICAL PATHWAY
Saltern--
alue to
BINDING LECTIN I
↳ to be discovered
pathray
classi cal
pathway PATHWAY
, CLASSICAL PATHWAY
>
-
includes C to C
S C , S,
> G is
- a
complex protein
>
- 3
types of complexes
=
C , S2
polypeptide
>
-
>
-
211
·........ -q polypeptide chains each chain has 3 domains
-
has a ,
q has 6 x3 18 domains
=
..
G
·
dimers and
-
Cr and Cs are are
present on
Antigen
-
L
both sides
of 19
.
-
this attachment C, w cleaves (
>
- Upon ,
C, s cleaves Cy
G ↓ ↓ 4 a
,
a)
⑳ CS
↓ ↓
⑭
Gb1 Da # Cyb B
↳ inflammation
↓
-
Sinflammation
Anaphylaxin
↓
convertase
Czb Cyb complex called
C
and
>
-
form a
which cleanes ↳ into and
Sub a
↓
⑳ 3
Ag
conversace
attaches to /
↓
with Cyb and G b
⑮
,
↑
1
G
·⑤⑱
*
Antigen
>
-
Complement proteins -
nur ne num
:
made cells
group of plasma proteins by LIVER mainly partially by
-
-> immune
. ,
present
Blood lymph extracellulalfluid
&
- in
-
"complement , destruction
of pathogen
so
> 30
-
-mostly proteolytic enzymes -
INACTIVE
↓ Paleoge a => COMPLEMENT
ACTIVATION
-
involved
in
destruction
/causes
ACTIVE
&
=> COMPLEMENT FIXATION >
-
diagnosis of infectious ① ↑
auto immune diseases
. phagocytosis
②
inflammation
③
Cytolysis
COMPLEMENT ACTIVATION
pathways
I
Antibody independent , >
Ab dependent
[INNATE IS] ⑭ [ACQUIRED IS]
Act as a
bridge
W ↓ V
ALTERNATIVE MANNOSS
PATHWAY
CLASSICAL PATHWAY
Saltern--
alue to
BINDING LECTIN I
↳ to be discovered
pathray
classi cal
pathway PATHWAY
, CLASSICAL PATHWAY
>
-
includes C to C
S C , S,
> G is
- a
complex protein
>
- 3
types of complexes
=
C , S2
polypeptide
>
-
>
-
211
·........ -q polypeptide chains each chain has 3 domains
-
has a ,
q has 6 x3 18 domains
=
..
G
·
dimers and
-
Cr and Cs are are
present on
Antigen
-
L
both sides
of 19
.
-
this attachment C, w cleaves (
>
- Upon ,
C, s cleaves Cy
G ↓ ↓ 4 a
,
a)
⑳ CS
↓ ↓
⑭
Gb1 Da # Cyb B
↳ inflammation
↓
-
Sinflammation
Anaphylaxin
↓
convertase
Czb Cyb complex called
C
and
>
-
form a
which cleanes ↳ into and
Sub a
↓
⑳ 3
Ag
conversace
attaches to /
↓
with Cyb and G b
⑮
,
↑
1
G
·⑤⑱
*
Antigen
