QUESTIONS WITH COMPLETE
ANSWERS { GRADED A+}
acute pain - ✔✔Recent onsest of pain that abates as healing occurs, serves as a
warning that something is wrong
addiction - ✔✔A chronic neurological and biological disease characterized by the
behaviors that include one or more of the following: impaired control over drug
use, compulsive use despite harm, and craving to use the opioid for effects other
than pain relief
adjuvant analgesics - ✔✔A drug that has a primary indication other than pain but
is an analgesic for some painful conditions; sometimes referred to as a coanalgesic
agonist-antagonist - ✔✔A type of opioid that binds to the kappa opioid receptor
site acting as an agonist (capable of producing analgia) and simultaneously to the
mu receptor opioid receptor site acting as an antagonist (reversing mu effects)
, Allodynia - ✔✔Pain due to a stimulus that does not normally provoke pain
Antagonist - ✔✔Drug that competes with agonists for opioid receptor binding
sites, they displace agonists, inhibiting their action
breakthrough pain - ✔✔Pain that occurs between doses of pain medication
ceiling effect - ✔✔An analgesic dose above which further dose increments
produce no change in effect
central sensitization - ✔✔a key central mechanism of neuropathic pain; the
abnormal hyperexcitability of central neurons in the spinal cord, which results
from complex changes induced by the incoming afferent barrages of nociceptors
Chronic or persistent pain - ✔✔pain that may or may not be time limited but that
persists beyond the usual course/time of tissue healing
comfort-function goal - ✔✔the pain rating identified by the individual patient
above which the patient experiences interference with function and quality of life
(e.g., activities the patient needs or wishes to perform)
efficacy - ✔✔The extent to which a drug or another treatment "works" and can
produce the effect in question - analgesia in this context
half-life - ✔✔The time it takes for the plasma concentration to be reduced by 50%