NAPLEX 2023 STUDY TIP GIRLS AND
KEY DRUG GUYS WITH QUESTIONS
AND ANSWERS | LATEST UPDATE {
GRADED A+}
What are the diagnostic criteria for diabetes (tests & values)? - ✔✔A1c (BG over
past 3 months): at least 6.5%
FPG (BG at test time): at least 126 mg/dL
OGTT (2-hr BG): at least 200 mg/dL
What are the diagnostic criteria for prediabetes (tests & values)? - ✔✔A1c (BG
over past 3 months): 5.7-6.4%
FPG (BG at test time): 100-125 mg/dL
OGTT (2-hr BG): 140-199 mg/dL
What should be the glycemic targets in patients with diabetes?
,Is this the same of different in pregnant patients? - ✔✔A1c: < 7%
FPG: 80-130 mg/dL (pregnant: 95 mg/dL or less)
2-hr PPG: < 180 mg/dL (pregnant: 120 mg/dL or less)
*1-hr PPG (pregnant only): 140 mg/dL or less
What are the long-term complications of diabetes? - ✔✔Microvascular:
1. Retinopathy
2. Diabetic nephropathy (kidney disease)
3. Peripheral neuropathy (risk amputations)
4. Autonomic neuropathy
Macrovascular: ASCVD
1. CAD (including MI)
2. CVA (including stroke)
3. PAD
,What is the 1st-line treatment for T2DM? - ✔✔Metformin + lifestyle changes
What is the 2nd-line treatment or add-on therapy of choice for patients with T2DM
and either: ASCVD or high risk, HF, or CKD? - ✔✔Generally, either a GLP-1a or
SGLT2i...
-ASCVD: add-on a GLP-1a or SGLT2i to metformin
-HF: add-on an SGLT2i with CV benefit to metformin
-CKD: add-on an SGLT2i (preferred if albuminuria) or GLP-1a
What class(es) of medications for diabetes are best for weight loss? - ✔✔GLP-1a
or SGLT2i
What class(es) of medications for diabetes are best for minimizing hypoglycemia
risk? - ✔✔DPP-4i, GLP-1a, SGLT2i or TZD
What antidiabetic agent combinations should be avoided? - ✔✔AVOID:
1. DPP4-i + GLP-1a
2. SU + insulin
, What is the typical starting dose for a basal-bolus insulin regimen in T1DM? -
✔✔0.5 units/kg/day dosed as 50% basal and 50% bolus insulin (with bolus dose
divided evenly among 3 meals).
*kg using total body weight (TBW)
Do starting doses of insulin for a basal-bolus dose use adjusted body weight, ideal
body weight, total body weight, or actual body weight? - ✔✔Total body weight
(TBW)
How do you do dosing conversions between insulins? - ✔✔Most insulin
conversions are 1:1
-Exception #1: BID NPH to daily insulin glargine... use 80% of the total daily dose
of NPH as your insulin glargine dose
-Exception #2: Toujeo to insulin glargine or detemir... use 80% of the Toujeo dose
as the new dose
How long can Humalog Mix 50/50 and 75/25 PENS be stored at room
temperature? - ✔✔10 days
How long can Humulin 70/30 pens be stored at room temperature? - ✔✔10 days
KEY DRUG GUYS WITH QUESTIONS
AND ANSWERS | LATEST UPDATE {
GRADED A+}
What are the diagnostic criteria for diabetes (tests & values)? - ✔✔A1c (BG over
past 3 months): at least 6.5%
FPG (BG at test time): at least 126 mg/dL
OGTT (2-hr BG): at least 200 mg/dL
What are the diagnostic criteria for prediabetes (tests & values)? - ✔✔A1c (BG
over past 3 months): 5.7-6.4%
FPG (BG at test time): 100-125 mg/dL
OGTT (2-hr BG): 140-199 mg/dL
What should be the glycemic targets in patients with diabetes?
,Is this the same of different in pregnant patients? - ✔✔A1c: < 7%
FPG: 80-130 mg/dL (pregnant: 95 mg/dL or less)
2-hr PPG: < 180 mg/dL (pregnant: 120 mg/dL or less)
*1-hr PPG (pregnant only): 140 mg/dL or less
What are the long-term complications of diabetes? - ✔✔Microvascular:
1. Retinopathy
2. Diabetic nephropathy (kidney disease)
3. Peripheral neuropathy (risk amputations)
4. Autonomic neuropathy
Macrovascular: ASCVD
1. CAD (including MI)
2. CVA (including stroke)
3. PAD
,What is the 1st-line treatment for T2DM? - ✔✔Metformin + lifestyle changes
What is the 2nd-line treatment or add-on therapy of choice for patients with T2DM
and either: ASCVD or high risk, HF, or CKD? - ✔✔Generally, either a GLP-1a or
SGLT2i...
-ASCVD: add-on a GLP-1a or SGLT2i to metformin
-HF: add-on an SGLT2i with CV benefit to metformin
-CKD: add-on an SGLT2i (preferred if albuminuria) or GLP-1a
What class(es) of medications for diabetes are best for weight loss? - ✔✔GLP-1a
or SGLT2i
What class(es) of medications for diabetes are best for minimizing hypoglycemia
risk? - ✔✔DPP-4i, GLP-1a, SGLT2i or TZD
What antidiabetic agent combinations should be avoided? - ✔✔AVOID:
1. DPP4-i + GLP-1a
2. SU + insulin
, What is the typical starting dose for a basal-bolus insulin regimen in T1DM? -
✔✔0.5 units/kg/day dosed as 50% basal and 50% bolus insulin (with bolus dose
divided evenly among 3 meals).
*kg using total body weight (TBW)
Do starting doses of insulin for a basal-bolus dose use adjusted body weight, ideal
body weight, total body weight, or actual body weight? - ✔✔Total body weight
(TBW)
How do you do dosing conversions between insulins? - ✔✔Most insulin
conversions are 1:1
-Exception #1: BID NPH to daily insulin glargine... use 80% of the total daily dose
of NPH as your insulin glargine dose
-Exception #2: Toujeo to insulin glargine or detemir... use 80% of the Toujeo dose
as the new dose
How long can Humalog Mix 50/50 and 75/25 PENS be stored at room
temperature? - ✔✔10 days
How long can Humulin 70/30 pens be stored at room temperature? - ✔✔10 days
