ILE VI - CKD
potassium is primarily regulated in the kidney via ___
aldosterone
increase aldosterone = ___ potassium
increase
true or false: glomerular hyperfiltration is a normal adaptation to
declining kidney function that is okay in the short term but not good
chronically
true
how long must symptoms of CKD be present for diagnosis?
3 months
2 leading causes of CKD
DM and HTN
general pathophysiology of CKD starts with ___ ___ ___
chronic kidney insult
general pathophysiology of CKD = chronic kidney insult LEADING TO
___ ___ ___/___
irreversible nephron loss/death
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death LEADING TO ___ ___ ___ ___ ___
increased burden on remaining nephrons
, general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons LEADING TO ____
hyperfiltration
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration LEADING TO ___ ___ ___
fibrosis and scarring
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration --> fibrosis and scarring LEADING TO ___
___ ___ ___ ___
increased rate of nephron death
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration --> fibrosis and scarring --> increased rate of
nephron death ULTIMATELY RESULTING IN ___
uremia
CKD is ___ meaning there are no symptoms until GFR is very, very low
silent
the kidneys are both the target and the cause of ___
HTN
the number one reason for death in patients with CKD is what?
cardiovascular disease
potassium is primarily regulated in the kidney via ___
aldosterone
increase aldosterone = ___ potassium
increase
true or false: glomerular hyperfiltration is a normal adaptation to
declining kidney function that is okay in the short term but not good
chronically
true
how long must symptoms of CKD be present for diagnosis?
3 months
2 leading causes of CKD
DM and HTN
general pathophysiology of CKD starts with ___ ___ ___
chronic kidney insult
general pathophysiology of CKD = chronic kidney insult LEADING TO
___ ___ ___/___
irreversible nephron loss/death
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death LEADING TO ___ ___ ___ ___ ___
increased burden on remaining nephrons
, general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons LEADING TO ____
hyperfiltration
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration LEADING TO ___ ___ ___
fibrosis and scarring
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration --> fibrosis and scarring LEADING TO ___
___ ___ ___ ___
increased rate of nephron death
general pathophysiology of CKD = chronic kidney insult leading -->
irreversible nephron loss/death --> increased burden on remaining
nephrons --> hyperfiltration --> fibrosis and scarring --> increased rate of
nephron death ULTIMATELY RESULTING IN ___
uremia
CKD is ___ meaning there are no symptoms until GFR is very, very low
silent
the kidneys are both the target and the cause of ___
HTN
the number one reason for death in patients with CKD is what?
cardiovascular disease
