505 Pharmacology (Renal)
What is considered an uncomplicated UTI?
Healthy, female, and age 15-45 w/ no structural abnormalities.
When should you treat asymptomatic bacteriuria?
Pregnant or undergoing endoscopic procedures with mucosal damage.
What are the four first line treatments for uncomplicated UTIs and their
durations?
1) Nitrofurantoin 5-7 days
2) Fosfomycin x 1
3) Tri/Sulf 3 days
4) Trimethoprim 3 days
What are the three second line treatments for an uncomplicated UTI?
1) Ciprofloxacin or Levofloxacin
2) Amoxicillin/Clavulanate
3) Oral cephalosporins (cefixime)
Nitrofuratonin: MOA
Inhibit bacterial acetylCOA.
Nitrofuratonin: Side Effects (4)
, 1) Brown/orange urine
2) G6PD hemolytic anemia
3) Peripheral Neuropathy
4) Pulmonary/Hepatic Toxicity
Nitrofuratonin: Contraindications (3)
- CrCl < 60
- Elderly
- Pyelonephritis
What 3 things do you want to monitor when you put a patient on
nitrofuratonin?
What bacteria does it NOT cover?
BUN, creatinine, and urine output.
No anaerobic coverage.
Fosfomycin: MOA
Inactivate pyruvyl transferase.
Fosfomycin: Side Effects (3)
- N/V/D/Abd pain
- Vaginitis
- Rash
Fosfomycin: Directions
Mix into 3-4 ounces cold water (with or without food).
What is considered an uncomplicated UTI?
Healthy, female, and age 15-45 w/ no structural abnormalities.
When should you treat asymptomatic bacteriuria?
Pregnant or undergoing endoscopic procedures with mucosal damage.
What are the four first line treatments for uncomplicated UTIs and their
durations?
1) Nitrofurantoin 5-7 days
2) Fosfomycin x 1
3) Tri/Sulf 3 days
4) Trimethoprim 3 days
What are the three second line treatments for an uncomplicated UTI?
1) Ciprofloxacin or Levofloxacin
2) Amoxicillin/Clavulanate
3) Oral cephalosporins (cefixime)
Nitrofuratonin: MOA
Inhibit bacterial acetylCOA.
Nitrofuratonin: Side Effects (4)
, 1) Brown/orange urine
2) G6PD hemolytic anemia
3) Peripheral Neuropathy
4) Pulmonary/Hepatic Toxicity
Nitrofuratonin: Contraindications (3)
- CrCl < 60
- Elderly
- Pyelonephritis
What 3 things do you want to monitor when you put a patient on
nitrofuratonin?
What bacteria does it NOT cover?
BUN, creatinine, and urine output.
No anaerobic coverage.
Fosfomycin: MOA
Inactivate pyruvyl transferase.
Fosfomycin: Side Effects (3)
- N/V/D/Abd pain
- Vaginitis
- Rash
Fosfomycin: Directions
Mix into 3-4 ounces cold water (with or without food).
