BICH 411 Exam 1
Glycolysis is an anabolic pathway (T/F) - ANS-False
The last reaction of glycolysis is catalyzed by: - ANS-Pyruvate Kinase
Which of the following intermediates of glycolysis are high energy compounds?
A. Glucose 6-phosphate
B. Fructose 1,6-bisphosphate
C. Dihydroxyacetone phosphate
D. 1,3-Bisphosphoglycerate - ANS-1,3-Bisphosphoglycerate
The conversion of glyceraldehyde 3-phosphate into 1,3-bisphosphoglycerate involves: -
ANS-the formation of a covalent thioester intermediate
the conversion of dihydroxyacetone phosphate into glyceraldehye 3-phosphate
involves: - ANS-an enediol intermediate
What are the final products of aerobic catabolism of glucose? - ANS-CO2 and H2O
The 9th reaction of glycolysis is catalyzed by: - ANS-Enolase
(T/F) the first committed step of glycolysis is catalyzed by hexokinase - ANS-False
Which of the following is not a substrate of Hexokinase?
A. Fructose
B. Glucose
C. Mannose
D. Galactose - ANS-Galactose
The first committed step of glycolysis is catalyzed by: - ANS-Phosphoglycerate kinase
The conversion of 3-phosphoglycerate into 2-phosphoglycerate invoves: - ANS-a
phosphorylated histine residue
Enolase catalyzes which reaction - ANS-the dehydration of 2-phosphoglycerate
Which of the following enzymes catalyze an irreversible reaction?
A. Phosphoglucose isomerase
, B. Phosphofructokinase-1
C. Aldolase
D. Glyceraldehyde-3-phosphate dehydrogenase
E. Phosphoglycerate kinase - ANS-Phosphoglucose isomerase
Lactate produced by anaerobic muscle tissue is:
a. stored in muscle until oxygen is available.
b. carried by the blood to the liver for gluconeogenesis and converted to glucose.
c. further reduced to glycerol in muscle.
d. transferred to erythrocytes to release oxygen from hemoglobin.
e. none of the above. - ANS-B. carried by the blood to the liver for gluconeogenesis and
converted to glucose
(T/F) Glycolytic enzymes are found in the mitochondria - ANS-False
(T/F) Glycolysis is an exergonic process - ANS-True
The oxidation of one molecule of glucose by anaerobic glycolysis yields a net of: -
ANS-2 moles of lactate and 2 moles of ATP
The three irreversible steps of glycolysis are catalyzed by: - ANS-hexokinase,
phosphofructokinase-1, pyruvate kinase
Under anaerobic conditions, skeletal muscle generates lactate from pyruvate to: -
ANS-Regenerate NAD+ for further glycolysis
The reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase involves: -
ANS-the formation of a covalent thioester intermediate
Glucokinase:
A. has a Km for glucose considerably greater than the normal blood glucose
concentration
B. is found in the muscle tissue
C. is inhibited by glucose-6-phosphate
D. is an isozyme of phosphofructokinase
is metabolically important only when glucose concentration is low - ANS-A. has a Km for
glucose considerably greater than the normal blood glucose concentration
Which of the enzymes listed below is used in both gluconeogenic and glycolytic
pathways?
Glycolysis is an anabolic pathway (T/F) - ANS-False
The last reaction of glycolysis is catalyzed by: - ANS-Pyruvate Kinase
Which of the following intermediates of glycolysis are high energy compounds?
A. Glucose 6-phosphate
B. Fructose 1,6-bisphosphate
C. Dihydroxyacetone phosphate
D. 1,3-Bisphosphoglycerate - ANS-1,3-Bisphosphoglycerate
The conversion of glyceraldehyde 3-phosphate into 1,3-bisphosphoglycerate involves: -
ANS-the formation of a covalent thioester intermediate
the conversion of dihydroxyacetone phosphate into glyceraldehye 3-phosphate
involves: - ANS-an enediol intermediate
What are the final products of aerobic catabolism of glucose? - ANS-CO2 and H2O
The 9th reaction of glycolysis is catalyzed by: - ANS-Enolase
(T/F) the first committed step of glycolysis is catalyzed by hexokinase - ANS-False
Which of the following is not a substrate of Hexokinase?
A. Fructose
B. Glucose
C. Mannose
D. Galactose - ANS-Galactose
The first committed step of glycolysis is catalyzed by: - ANS-Phosphoglycerate kinase
The conversion of 3-phosphoglycerate into 2-phosphoglycerate invoves: - ANS-a
phosphorylated histine residue
Enolase catalyzes which reaction - ANS-the dehydration of 2-phosphoglycerate
Which of the following enzymes catalyze an irreversible reaction?
A. Phosphoglucose isomerase
, B. Phosphofructokinase-1
C. Aldolase
D. Glyceraldehyde-3-phosphate dehydrogenase
E. Phosphoglycerate kinase - ANS-Phosphoglucose isomerase
Lactate produced by anaerobic muscle tissue is:
a. stored in muscle until oxygen is available.
b. carried by the blood to the liver for gluconeogenesis and converted to glucose.
c. further reduced to glycerol in muscle.
d. transferred to erythrocytes to release oxygen from hemoglobin.
e. none of the above. - ANS-B. carried by the blood to the liver for gluconeogenesis and
converted to glucose
(T/F) Glycolytic enzymes are found in the mitochondria - ANS-False
(T/F) Glycolysis is an exergonic process - ANS-True
The oxidation of one molecule of glucose by anaerobic glycolysis yields a net of: -
ANS-2 moles of lactate and 2 moles of ATP
The three irreversible steps of glycolysis are catalyzed by: - ANS-hexokinase,
phosphofructokinase-1, pyruvate kinase
Under anaerobic conditions, skeletal muscle generates lactate from pyruvate to: -
ANS-Regenerate NAD+ for further glycolysis
The reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase involves: -
ANS-the formation of a covalent thioester intermediate
Glucokinase:
A. has a Km for glucose considerably greater than the normal blood glucose
concentration
B. is found in the muscle tissue
C. is inhibited by glucose-6-phosphate
D. is an isozyme of phosphofructokinase
is metabolically important only when glucose concentration is low - ANS-A. has a Km for
glucose considerably greater than the normal blood glucose concentration
Which of the enzymes listed below is used in both gluconeogenic and glycolytic
pathways?
