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Pathophysiology Exam 1 UTMB Questions With Verified Answers

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Pathophysiology Exam 1 UTMB Questions With Verified Answers Migraine without Aura 85% of migraines, pulsatile, throbbing, unilateral, can last 4-72 hours, aggravated by physical activity, can be accompanied by N/V, sensitivity to light, sounds, smells, and visual disturbances Migraine with Aura 15% of migraines, pulsatile, throbbing, unilateral, aggravated by physical activity, can be accompanied by N/V, sensitivity to light, sounds, smells, and visual disturbance, develops over 5-20 mins and can last an hour, usually genetic Static Migranosis Migraine lasting longer than 72 hours, need to be admitted for IV pain relief Cluster Headache Severe, unilateral, 15 min-3 hour headache. Can have for weeks or months at a time, sxs disappear then come back. Hereditary. Tension Headache Hat-band type pain, usually not debilitating, dull, aching headache Chronic Daily Headache 15 or more headaches per month, could be due to medication overuse, caffeine, etc. Non-Pharmalogical measures for migraine treatment -Control risk factors and triggers-stress, sleep deprivation, alcohol, foods (eg. chocolate, msg, aged cheese), visual stimuli, estrogen. -Behavior interventions-stress management, biofeedback, relaxation therapy, cognitive therapy -Avoid aggravating factors (specific to person) First line severe headache treatment Anti-seizure meds, non-narcotics, narcotics, NSAIDS, triptans, ergotamine, midrin Acute non-responder care for headaches (20-25% don't respond to first line treatment) Reglan, prophylaxis, beta blockers for prevention Seizure vs Epilepsy Epilepsy: chronic state of recurrent seizures Seizure: temporary disturbance in brain activity causing nerves to fire excessively Provoked seizures Fever (common in children), electrolyte imbalances, hypoglycemia, CNS infection or damage, meningitis, hypoxia, eclampsia, tumors Partial (focal) seizures w/o impairment of consciousness somatosensory disturbances, involuntary motor movement, autonomic nervous system may be affected (sweating, tachycardia, hyper/hypotension, pupil changes) Partial (focal) seizures with impairment of consciousness Occur in temporal lobe, can start here and then move to other areas. Psychomotor symptoms-lip smacking, petting clothes, eating. Can have feelings of deja vu, fear, hallucinations, commonly confused with psych disorders. Confusion postictally is common. Generalized seizures seizures that involve the entire brain, can all be followed by Todd's paralysis for 24 hours (temporary paresis, hemianopia, aphasia-speech/understanding). Include tonic-clonic, absence, myoclonic, tonic, clonic, and atonic seizures tonic-clonic seizure (grand mal) generalized seizure in which the patient loses consciousness and has jerking movements of paired muscle groups, loss of bladder and bowel control

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UTMB Patho Exam 1 Questions With Verified
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Erythropoiesis
• The main process of RBC regulation
• When decreased oxygen levels are detected, they kidneys release erythropoietin which stimulates
the red bone marrow to make and release more RBCs


Normocytic
Normal size


Microcytic
Small size


Macrocytic
Large size


Normochromic
Normal color


Hypochromic
Low color


Megaloblastic
enlarged and abnormally shaped


Anemia
Low numbers of RBC's, low hemoglobin, or low hematocrit resulting from

autoimmune diseases
Blood Loss
Bone Marrow failure from radiation infection or tumors
Erythropoietin insufficiency
Hemolysis
Malnutrition (Iron, Folate, Vitamin B12/B6)


Symptoms of Anemia
Fatigue
Shortness of Breath
Pallor
Low Blood Pressure
Anxiety
increased Heart Rate


Normal RBC count in males
4.2-5.4 million

, Normal RBC count in females
3.6-5.0


Normal Hemoglobin count in males
14-16.5


Normal Hemoglobin count in females
12-15


Normal Hematocrit in males
40-50%


Normal Hematocrit in females
37-47%


Iron Deficiency Anemia
Impaired oxygen transport due to lack of hemoglobin, tissue hypoxia, microcytic hypochromic anemia


Etiology of Iron Deficiency Anemia
Dietary Deficiency- not enough iron B12/B6 in diet
Bleeding- menstruation, GI Bleeding (NSAIDS), peptic ulcers, polyps, hemorrhoids, cancer
Increased Demands- pregnancy, cow's milk without supplementation, Adolescents growth spurts,
diet, and menstruation


Treatment for Iron Deficiency anemia
Increase dietary intake
Ferrous Sulfate
Iron Dextran (IM or IV)


Hemolytic Amenias
Something in the blood is destroying the RBCs
Can be genetic or acquired through exposure to various drugs or diseases such as malaria, DIC severe
burns, venoms etc


Sickle Cell Anemia
Mutation in the hemoglobin molecule with the substitution of valine for glutamic acid resulting in the
abnormal S shape of the hemoglobin molecule
heterozygous reccessive


Factors leading to a sickle cell crisis
cold, stress, physical exertion, infection, hypoxia, dehydration, acidosis


Megaloblastic Anemia
Enlarged Malformed RBCs
Usually caused by B12 and folic acid deficiencies

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