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Verified 2024 Version
IBS-C and functional constipation (FC) may exist on a spectrum, whereby patients who experience severe
abdominal pain and constipation are on one end (FC), and patients who experience constipation with no
pain at all are on the other end (IBS-C). T/F - ✔✔False
Which of the following are ALL considered red flags in someone presenting with diagnosed or suspected
IBS? - ✔✔Age of onset > 50 years; family history of colorectal cancer/IBD/coeliac disease; rectal
bleeding/anaemia; nocturnal waking symptoms; unintentional weight loss; persistent daily diarrhoea;
recurrent vomiting; fever; progressive/severe/stable symptoms.
The gold standard method of diagnosing coeliac disease is via gastroscopy with 4-6 biopsy samples from
the small bowel. T/F - ✔✔True
Identify the INCORRECT statement about the causes of IBS: - ✔✔IBS is most likely caused by poor diet, in
particular a low fibre intake. Correct statements: a) The precise cause of IBS is unknown, Accelerated or
delayed colonic transit may contribute to diarrhoea or constipation predominant symptoms in IBS, IBS is
a disorder of brain-gut interaction and psychological factors (such as stress and anxiety) may influence
symptoms, Alterations in the gut microbiota may drive the onset of IBS, as seen in post-infective IBS.
The purpose of the gluten challenge is to induce changes in antibody levels and/or the small intestinal
mucosa, so that undetected coeliac disease can be detected via serology tests and/or duodenal biopsies.
T?F - ✔✔True
Although FBDs can be classified into different conditions (e.g. IBS; functional diarrhoea; functional
constipation), considerable overlap exists and these conditions are thought to exist on a continuum. T/F -
✔✔True
Identify the correct response about screening tests for coeliac disease: - ✔✔Genetic tests are not
affected by gluten intake (unlike serology tests and duodenal biopsies), so they are a useful tool to rule
out (but not diagnose) coeliac disease in people following a gluten free diet.
, GOS are universally malabsorbed because humans lack the enzyme α-galactosidase needed to hydrolyse
this carbohydrate into simple sugar units - ✔✔True
Lactose malabsorption is more common among people with IBS than those without. - ✔✔False
Sorbitol and mannitol may induce gastrointestinal symptoms regardless of the extent to which they're
absorbed. - ✔✔True
Approximately one third of people malabsorb fructans in the small intestine, facilitating their delivery to
the large intestine where they are rapidly fermented by resident bacteria. - Noted T/F - ✔✔False
Re-testing lactose tolerance may be worthwhile as lactose tolerance can change over time, especially if
lactose intolerance has occurred as a result of damage to the intestinal epithelium (due to untreated
coeliac disease or intestinal inflammation) T/F - ✔✔True
Fructose malabsorption is virtually universal, so most patients with IBS will benefit from a long term, low
fructose diet. T/F - ✔✔False
Choose the CORRECT statement about the effects of food processing on FODMAP composition: -
✔✔Food processing techniques thought to affect FODMAP content include boiling, canning, pressing,
straining, pickling, fermentation, activation and 'sprouting'
Prior to analysing fresh fruit and vegetables for FODMAP content, 10 different samples are selected,
collected and pooled T/F - ✔✔True
Foods rich in excess fructose include apple, pear, cherries, fig, honey, mango, boysenberries, sugar snap
peas, asparagus T/F - ✔✔True
Foods rich in fructans and/or GOS include garlic, onion, leek, artichoke, wheat/rye/barley based
breakfast cereal, bread, biscuits, red kidney beans, split peas, falafels, baked beans, cashews and
pistachios, vegetarian mince T/F - ✔✔True