GMS6520 Review Exam 2
Which of the following drugs has CNS effects that plateau at higher doses?
(A) GHB
(B) Barbiturates
(C) Alcohol
(D) Benzodiazapenes
(E) Chloral Hydrate - ANS-(D) Benzodiazapenes
Do benzodiazapenes increase the potency and/or efficacy of GABA toward the GABAa
receptor?
(A) Potency
(B) Efficacy
(C) Both potency and efficacy
(D) Neither potency or efficacy - ANS-(A) Potency
Which drug combinations may involve asymmetric metabolic cross tolerance and/or
standard metabolic tolerance? Choose all that apply.
(A) Pentobarbital then diazepam
(B) Diazepam then Pentobarbital
(C) Amobarbital then chlordiazepoxide
(D) Chlordiazepoxide then Amobarbital
(E) Alprazolam then Lorazepam
(F) Lorazepam then alprazolam
(G) Amobarbital then pentobarbital
(H) Pentobarbital then amobarbital - ANS-(A) Pentobarbital then diazepam
(C) Amobarbital then chlordiazepoxide
(G) Amobarbital then pentobarbital
(H) Pentobarbital then amobarbital
Which drug could potentially be used as-needed in order to reduce test-anxiety in
extreme cases, without affecting mental function?
(A) Chloral hydrate
(B) Pentobarbital
(C) Propranolol
(D) Alprazolam
(E) Diazepam - ANS-(C) Propranolol
, A patient that has been prescribed alprazolam for their severe anxiety attempts suicide
by overdosing on the drug. While we know that this is unlikely to be fatal, what drug will
likely be given to the patient at the emergency room?
(A) Flumenazil
(B) Xanax
(C) Valium
(D) Dalmane
(E) Pentobarbital - ANS-(A) Flumenazil
Which of the following drugs is an OTC sedative?
(A) Alprozolam
(B) Zaleplon
(C) Pentobarbital
(D) Diphenhydramine
(E) Acetaminophen - ANS-(D) Diphenhydramine
Which class of drugs do you expect to maintain efficacy when applied in a transgenic
mouse model in which the glutamic acid decarboxylase enzyme is knocked out,
preventing the synthesis of GABA?
(A) Barbiturates
(B) Benzodiazepenes - ANS-(A) Barbiturates
The legal blood alcohol limit for driving most places in the US is 0.08% (though driving
is impaired at much lower levels). Based on the data table presented in the lecture, how
many 12 oz. beers would it take for a 25 year old female to exceed that limit? Assume
that they were all consumed within a short period of time, making metabolism negligible.
(A) 1
(B) 2
(C) 3
(D) 4
(E) 5 - ANS-(C) 3
What enzyme catalyzes the second step in the metabolism of ethanol?
(A) P450
(B) Acetaldehyde dehydrogenase
(C) Antidiuretic hormone
(D) Alcohol dehydrogenase - ANS-(B) Acetaldehyde dehydrogenase
Would you expect the concentration of dissolved CO2 to be higher or lower than normal
in the blood of a patient with a high blood alcohol content?
Which of the following drugs has CNS effects that plateau at higher doses?
(A) GHB
(B) Barbiturates
(C) Alcohol
(D) Benzodiazapenes
(E) Chloral Hydrate - ANS-(D) Benzodiazapenes
Do benzodiazapenes increase the potency and/or efficacy of GABA toward the GABAa
receptor?
(A) Potency
(B) Efficacy
(C) Both potency and efficacy
(D) Neither potency or efficacy - ANS-(A) Potency
Which drug combinations may involve asymmetric metabolic cross tolerance and/or
standard metabolic tolerance? Choose all that apply.
(A) Pentobarbital then diazepam
(B) Diazepam then Pentobarbital
(C) Amobarbital then chlordiazepoxide
(D) Chlordiazepoxide then Amobarbital
(E) Alprazolam then Lorazepam
(F) Lorazepam then alprazolam
(G) Amobarbital then pentobarbital
(H) Pentobarbital then amobarbital - ANS-(A) Pentobarbital then diazepam
(C) Amobarbital then chlordiazepoxide
(G) Amobarbital then pentobarbital
(H) Pentobarbital then amobarbital
Which drug could potentially be used as-needed in order to reduce test-anxiety in
extreme cases, without affecting mental function?
(A) Chloral hydrate
(B) Pentobarbital
(C) Propranolol
(D) Alprazolam
(E) Diazepam - ANS-(C) Propranolol
, A patient that has been prescribed alprazolam for their severe anxiety attempts suicide
by overdosing on the drug. While we know that this is unlikely to be fatal, what drug will
likely be given to the patient at the emergency room?
(A) Flumenazil
(B) Xanax
(C) Valium
(D) Dalmane
(E) Pentobarbital - ANS-(A) Flumenazil
Which of the following drugs is an OTC sedative?
(A) Alprozolam
(B) Zaleplon
(C) Pentobarbital
(D) Diphenhydramine
(E) Acetaminophen - ANS-(D) Diphenhydramine
Which class of drugs do you expect to maintain efficacy when applied in a transgenic
mouse model in which the glutamic acid decarboxylase enzyme is knocked out,
preventing the synthesis of GABA?
(A) Barbiturates
(B) Benzodiazepenes - ANS-(A) Barbiturates
The legal blood alcohol limit for driving most places in the US is 0.08% (though driving
is impaired at much lower levels). Based on the data table presented in the lecture, how
many 12 oz. beers would it take for a 25 year old female to exceed that limit? Assume
that they were all consumed within a short period of time, making metabolism negligible.
(A) 1
(B) 2
(C) 3
(D) 4
(E) 5 - ANS-(C) 3
What enzyme catalyzes the second step in the metabolism of ethanol?
(A) P450
(B) Acetaldehyde dehydrogenase
(C) Antidiuretic hormone
(D) Alcohol dehydrogenase - ANS-(B) Acetaldehyde dehydrogenase
Would you expect the concentration of dissolved CO2 to be higher or lower than normal
in the blood of a patient with a high blood alcohol content?
