BIOL 5500 FINAL EXAM 3 QUESTIONS
AND ANSWERS
Ab Effector functions
•Neutralization
•Complement fixation
•Opsonization
•Triggers physical mechanisms of pathogen elimination
•Triggers allergic responses, mast cell degradation
•Antibody dependent cellular cytotoxicity
FcyR1
binds to IgG3/1 involved in opsonization found on macrophages and DC (and
neutrophils and eosinophils) and leads to macrophage activation
FcyRIIB1
binds to IgG involved in inhibition of Naïve B cell activation found on mast cells and B
cells leads to inhibition
FcyRIII
binds to IgG3/1 involved in ADCC found on NK cells (and macrophages, neutrophils,
and eosinophils) leads to activation
FcER1
binds to IgE involved in degranulation found on mast cells (also basophils and
eosinophils) leads to activation
Poly-Ig Receptor
binds to J chain of dimeric IgA involved in transport/neutralization found on epithelial
cells of the intestine leads to transport
FcRN
binds to IgG involved in transport through the placenta or to extracellular space from
blood stream (requires acidic pH) found on the placenta or endothelial cells of the blood
vessels leads to transport/increased half-life
Response to Extracellular bacteria
Antibody/Complement mediated (TH17) leads to phagocytosis and inflammation
, Respones to Intracellular bacteria
Release of IL-12 produces IFN-gamma which leads to activation of macrophages and
phagocytosis
Response to Viral infection
oInnate: Type 1 IFN induced antiviral state and NK cell mediated killing
oAdaptive: Antibody neutralization and CD8+ T cell killing
i.e. of Changing Serotypes to Evade Host Response
S. pneumoniae
i.e. of Latency to Evade Host Response
HSV in trigeminal nerve
i.e. of Inhibiting APP to Evade Host Response
CMV
i.e. of Suppressing immune system of host to Evade Host Response
EBV makes IL-10 homolog
i.e. of Formation of a Biofilm to Evade Host Response
H. influenzae
Polysaccharide vaccines
consists of purified polysaccharides; T-INDEPENDENT and BROAD coverage
Conjugate
capsular polysaccharide coupled to toxin; T-DEPENDENT, many isotypes, ROBUST
and LONG-lasting
Intraepithelial lymphocytes
CD8+ T cells found integrated into the epithelial layer
Lamina propria
Peyer's patches (isolated lymph tissue): T and B cells (activation site), macrophages,
mast cells, DC recieves antigen and pathogens from M cells
Mesenteric Lymph Node
Control center for gut Immune System
Epithelium
Paneth and M cells
Paneth cells
AND ANSWERS
Ab Effector functions
•Neutralization
•Complement fixation
•Opsonization
•Triggers physical mechanisms of pathogen elimination
•Triggers allergic responses, mast cell degradation
•Antibody dependent cellular cytotoxicity
FcyR1
binds to IgG3/1 involved in opsonization found on macrophages and DC (and
neutrophils and eosinophils) and leads to macrophage activation
FcyRIIB1
binds to IgG involved in inhibition of Naïve B cell activation found on mast cells and B
cells leads to inhibition
FcyRIII
binds to IgG3/1 involved in ADCC found on NK cells (and macrophages, neutrophils,
and eosinophils) leads to activation
FcER1
binds to IgE involved in degranulation found on mast cells (also basophils and
eosinophils) leads to activation
Poly-Ig Receptor
binds to J chain of dimeric IgA involved in transport/neutralization found on epithelial
cells of the intestine leads to transport
FcRN
binds to IgG involved in transport through the placenta or to extracellular space from
blood stream (requires acidic pH) found on the placenta or endothelial cells of the blood
vessels leads to transport/increased half-life
Response to Extracellular bacteria
Antibody/Complement mediated (TH17) leads to phagocytosis and inflammation
, Respones to Intracellular bacteria
Release of IL-12 produces IFN-gamma which leads to activation of macrophages and
phagocytosis
Response to Viral infection
oInnate: Type 1 IFN induced antiviral state and NK cell mediated killing
oAdaptive: Antibody neutralization and CD8+ T cell killing
i.e. of Changing Serotypes to Evade Host Response
S. pneumoniae
i.e. of Latency to Evade Host Response
HSV in trigeminal nerve
i.e. of Inhibiting APP to Evade Host Response
CMV
i.e. of Suppressing immune system of host to Evade Host Response
EBV makes IL-10 homolog
i.e. of Formation of a Biofilm to Evade Host Response
H. influenzae
Polysaccharide vaccines
consists of purified polysaccharides; T-INDEPENDENT and BROAD coverage
Conjugate
capsular polysaccharide coupled to toxin; T-DEPENDENT, many isotypes, ROBUST
and LONG-lasting
Intraepithelial lymphocytes
CD8+ T cells found integrated into the epithelial layer
Lamina propria
Peyer's patches (isolated lymph tissue): T and B cells (activation site), macrophages,
mast cells, DC recieves antigen and pathogens from M cells
Mesenteric Lymph Node
Control center for gut Immune System
Epithelium
Paneth and M cells
Paneth cells
