Hypertensive
Vascular Disease &
Aneurysm
Dr Birtukan Ewunetu (MD, Pathologist)
07/15/2024
, Outlines
Blood pressure regulation
Hypertension and its complications
Vascular wall response to injury
Types of Hypertensive heart disease
Aneurysm and aortic dissection
07/15/2024
, Blood pressure regulation
Blood pressure is determined by cardiac out put and
vascular resistance
Vascular resistance is regulated at the level of the
arterioles, influenced by neural (adrenergic) and
hormonal (angiotensin) inputs
Cardiac output is determined by heart rate and stroke
volume
Blood volume in turn is regulated mainly by renal
sodium excretion or resorption
07/15/2024
, Cont’d
Kidneys influence peripheral resistance and
sodium excretion/retention primarily through the
renin angiotensin system
Renin, a major regulator of blood pressure, is
secreted by the kidneys in response to decreased
blood pressure
Renin cleaves angiotensinogen to angiotensin I
Angiotensin I converted to angiotensin II by ACE
07/15/2024
Vascular Disease &
Aneurysm
Dr Birtukan Ewunetu (MD, Pathologist)
07/15/2024
, Outlines
Blood pressure regulation
Hypertension and its complications
Vascular wall response to injury
Types of Hypertensive heart disease
Aneurysm and aortic dissection
07/15/2024
, Blood pressure regulation
Blood pressure is determined by cardiac out put and
vascular resistance
Vascular resistance is regulated at the level of the
arterioles, influenced by neural (adrenergic) and
hormonal (angiotensin) inputs
Cardiac output is determined by heart rate and stroke
volume
Blood volume in turn is regulated mainly by renal
sodium excretion or resorption
07/15/2024
, Cont’d
Kidneys influence peripheral resistance and
sodium excretion/retention primarily through the
renin angiotensin system
Renin, a major regulator of blood pressure, is
secreted by the kidneys in response to decreased
blood pressure
Renin cleaves angiotensinogen to angiotensin I
Angiotensin I converted to angiotensin II by ACE
07/15/2024
