Endocrine, Reproductive 3 Verified Questions And Answers For Peak Academic Achievement

glargine - Answer insulin analog, active tyrosine kinase no peak-plasma [] plateau, slow acting24h, iv lispro - Answer rapid-acting insulin right bef(normal insulin is short-1 h bef) meals, also emergency ketoacidosis glulisine - Answer rapid acting insulin aspart - Answer rapid acting insulin lente - Answer intermediate acting insulin NPH (isophane) - Answer intermediate acting insulin (w protamine) tolbutamide - Answer 1-gen sulfonylureas, short action chlorpropamide - Answer 1 gen sulfonylurea, long acting Glipizide - Answer Sulfonylurea, 2gen , short acting Glyburide - Answer Sulfonylurea, 2 gen, long acting oral, dec in renal disf adv: hypogly, weight gain int: hypoglycemia with cimetidine, insulin, salicylates, sulfonamides glymepiride - Answer 2gen sulfonylurea, long acting repaglinide - Answer insulin secretagogue, d-phenylalanine deriv, just bef meal, depolarizes K nateglinide - Answer Meglitinides, stimu insulin sec metmorfin - Answer for diabeters, ↑ tissue sensitivity to insulin and/or ↓ hepatic gluconeogenesis 2 | P a g e adv: possible lactic acidosis; gastrointestinal distress is common **no hypogly ACARBOSE - Answer for diabetes, α-glucosidase in brush borders of small intestine →↓ formation of absorbable carbohydrate →↓ postprandial glucose Side effects: GI discomfort, flatulence, and diarrhea—recent concern over potential hepatotoxicity **no hypogly PIOGLITAZONE - Answer thiazolidinedione, bind to PPAR's=transcibe insulin-resp genes adv:less hypoglycemia than sulfonylureas, but weight gain and edema reported ROSIGLITAZONE - Answer thiazolidinedione, bind to PPAR's=transcibe insulin-resp genes adv:less hypoglycemia than sulfonylureas, but weight gain and edema reported pramlintide - Answer synthetic version of amylin =slows the rate at which food is absorbed from the intestine, dec glu & apetite type 1 (sm) and type 2 diabetes exenatide - Answer diabetes, GLP-1 receptor full agonist (insulin sec) Side effects: nausea, hypoglycemia when used with oral sulfonylureas, poss fatal pancreatitis liraglutide - Answer GLP-1 analog, injection sitagliptin - Answer diabeters, inhi DPP-4 thereby inhibiting the inactivation of GLP-1 nasopharyngitis & UP resp inf, headache 3 | P a g e Linagliptin.............