Nodular surrounded by Fibrosis, Lacunar
variants, 70% of CHL, ages 20-30, doesn't
Nodular Sclerosis
express specific T or B Ags only CD 15,30 ,
Collagen bands and Mediastinal involvement.
Mixed inflammatory, lacks collagen and
Mixed Cellularity
Classical HL associated with EBV
Lymphocyte Rich Recently added, Abundant small lymphocytes.
Reed-Sternberg cells are neoplastic, Curable,
Hodgkin's systematic manifestations as fever, Spreadable, Least Common CHL type, No background,
Lymphocyte Depleted
variable inflammatory cells (PNLs), expresses CD 30 HIV related, Middle to elderly aged men.
Popcorn Appearance, Lack CD 15,30 has its
own B Ags, Most indolent, Vague nodular
Nodular Lymphocyte Predominant HL
pattern, Inflammatory background lacks
Eosinophils and plasma, EBV is -ve
Follicular proliferations, nodular appearance,
Normal germinal B cells but neoplastic
Indolent (Low grade) Follicular Centrocyte -Larger and cleaved nuclei with
Primary (Lymphoma) dense chromatin- express BCL2, not easily
curable, progress to Diffuse large.
B cell (CD 10,19,20) Most important in adults, 50% NHL, Round
irregular and cleaved B cells resemble
Diffuse large
Centroblasts and immunoblasts, Very large
and aggressive, Express Ags: CD 19,20,79a
Aggressive (High grade) Most Common in Childhood, Infected virally (EBV),
More common in mature cells, Always
Maybe: Endemic (Africa), Sporadic (Cosmopolitan),
Malignant, Maybe indolent or aggressive,
Immunodeficiency Associated (HIV), CNS
Non-Hodgkin's Monoclonal release Terminal
Neoplastic Deoxytransferase, B > T, Effacement and
Burkitt's (extra nodal) involvement Risk, High apoptotic and neoplastic
cells with light macrophages in Background "Starry
matted, Fish flesh.
Sky pattern", Shows CD 19,20,22 ,CD 10 and High
Ki67, MYC gene on chr.8 karyotyping.
Lymphadenopathy
Tissue is still not fully damaged, Bimodal (Age extremities), Large atypical
Congested, tender, Large germinal Non-specific Kidney or horse shoe appearance, CD 30,
T cell (CD 2,3,4,7,8) Anaplastic large
centers, PNL involve t(2;5), ALK positive has good
prognosis and vice versa.
Acute
Throbbing, Due to
Bacterial toxins Drainage, Suppporative The 1ry tumor may be occult and seed into L.
PNL Secondary (Metastatic Carcinoma) N, CD 45, and diagnosed by
Immunoperoxidase Technique.
Epithelioid, Langhans, Fibrosis, if lung =>
Hillar , Matted, Soft cold Caseation, Tuberculosis Non-neoplastic (Inflammation) Reactive
horseshoe, necrosis Caused By infection or cellular dipris
Specific
Lymphadenitis
Non-Caseating, Epithelioid, Langhan's,
Shawmann and Asteroid Bodies. Angiotensin Sarcoidosis
Converting Enzyme
In L.N. Cortex, Activate Humoral I.R. (B cells),
Large Germinal center, Vary in size, Light Chronic
Follicolar Hyperplasia
zone Proliferation Preserved Architecture,
increased central centrocyte
Proliferation of Paracortex, CMI (T cells),
Paracortical Hyperplasia
Infectious mononucleosis (EBV) Non-Specific
Draining Cancer, ex: Axillary and breast
Sinus Hyperplasia
cancer
Combines all of them Mixed Hyperplasia
variants, 70% of CHL, ages 20-30, doesn't
Nodular Sclerosis
express specific T or B Ags only CD 15,30 ,
Collagen bands and Mediastinal involvement.
Mixed inflammatory, lacks collagen and
Mixed Cellularity
Classical HL associated with EBV
Lymphocyte Rich Recently added, Abundant small lymphocytes.
Reed-Sternberg cells are neoplastic, Curable,
Hodgkin's systematic manifestations as fever, Spreadable, Least Common CHL type, No background,
Lymphocyte Depleted
variable inflammatory cells (PNLs), expresses CD 30 HIV related, Middle to elderly aged men.
Popcorn Appearance, Lack CD 15,30 has its
own B Ags, Most indolent, Vague nodular
Nodular Lymphocyte Predominant HL
pattern, Inflammatory background lacks
Eosinophils and plasma, EBV is -ve
Follicular proliferations, nodular appearance,
Normal germinal B cells but neoplastic
Indolent (Low grade) Follicular Centrocyte -Larger and cleaved nuclei with
Primary (Lymphoma) dense chromatin- express BCL2, not easily
curable, progress to Diffuse large.
B cell (CD 10,19,20) Most important in adults, 50% NHL, Round
irregular and cleaved B cells resemble
Diffuse large
Centroblasts and immunoblasts, Very large
and aggressive, Express Ags: CD 19,20,79a
Aggressive (High grade) Most Common in Childhood, Infected virally (EBV),
More common in mature cells, Always
Maybe: Endemic (Africa), Sporadic (Cosmopolitan),
Malignant, Maybe indolent or aggressive,
Immunodeficiency Associated (HIV), CNS
Non-Hodgkin's Monoclonal release Terminal
Neoplastic Deoxytransferase, B > T, Effacement and
Burkitt's (extra nodal) involvement Risk, High apoptotic and neoplastic
cells with light macrophages in Background "Starry
matted, Fish flesh.
Sky pattern", Shows CD 19,20,22 ,CD 10 and High
Ki67, MYC gene on chr.8 karyotyping.
Lymphadenopathy
Tissue is still not fully damaged, Bimodal (Age extremities), Large atypical
Congested, tender, Large germinal Non-specific Kidney or horse shoe appearance, CD 30,
T cell (CD 2,3,4,7,8) Anaplastic large
centers, PNL involve t(2;5), ALK positive has good
prognosis and vice versa.
Acute
Throbbing, Due to
Bacterial toxins Drainage, Suppporative The 1ry tumor may be occult and seed into L.
PNL Secondary (Metastatic Carcinoma) N, CD 45, and diagnosed by
Immunoperoxidase Technique.
Epithelioid, Langhans, Fibrosis, if lung =>
Hillar , Matted, Soft cold Caseation, Tuberculosis Non-neoplastic (Inflammation) Reactive
horseshoe, necrosis Caused By infection or cellular dipris
Specific
Lymphadenitis
Non-Caseating, Epithelioid, Langhan's,
Shawmann and Asteroid Bodies. Angiotensin Sarcoidosis
Converting Enzyme
In L.N. Cortex, Activate Humoral I.R. (B cells),
Large Germinal center, Vary in size, Light Chronic
Follicolar Hyperplasia
zone Proliferation Preserved Architecture,
increased central centrocyte
Proliferation of Paracortex, CMI (T cells),
Paracortical Hyperplasia
Infectious mononucleosis (EBV) Non-Specific
Draining Cancer, ex: Axillary and breast
Sinus Hyperplasia
cancer
Combines all of them Mixed Hyperplasia
