~
Cholesterol is present in tissues & plasma either as : -Cholesterol is a 27 Carbon unit structure
Free cholesterol synthesized
It is in the ER cytosola begins
~
or &
Combined with
long chain FA Cholesteryl ester
. with Acetyl-CoA
~
In plasma both forms are transported in lipoproteins.
It is amphipathic lipid I The third reaction is the
~
~
has both
an polar rate-limiting step ; the
nonpolar ends reduction of HMG-CoA to mevalonate
It is synthesized in tissues from acetyl CoA En HMG CoA reductase
integral
~
membrane protein
many an
. .
,
It is the precursor of all other steroids in the body of the Smooth
~
this
,
ER . .
catalyzes step -
including corticosteroids , sex hormones , bile acids
& mmmm
vitamin D
. Summary :
cholesterol is found foods of animal .
1 Condensation of 3 acetyl to form 6)
in
origin
~
groups
. a
Cholesterol intermediate, mevalonate·
reaches the
tissues
through Plasma low
~
density lipoprotein LDG .
.
2 The conversion of mavelonate to activated
~
HDL removes cholesterol from tissues & transports it isoprene units .
to the liver where it is eliminated directly or converted 3 .
Polymerization of six 5-carbon isoprene
to bile acids first in the
process known as Reverse units to form the 30-c linear squalene
.
Cholesterol Transport Cyclization of squalene to form 4 of
rings
. 4
the steroid nucleus , with further series of
changes
oxidations, removal of
Extra cholesterol in bile lead to the formation of
migration
~
can or methyl groups
Gall stones to produce cholesterol .
levels of LDL of cholesteral contribute to the
High
~
mus
buildup of
plaque in arteries ,
leading to atherosclerosis , Cholesterol structure :
various cardiovascular diseases All sterols have 4 fused
which rings
~
can cause .
Card V diseases
. : Cerebrovascular , coronary & that form the steroid nucleus , with
peripheral vascular disease. a hydroxyl group at C-3 .
Half of the body's cholesterol is
~
Foo made
my day by
-
Synthesis , the rest comes from diet
The liver & intestine responsible for
~
are about 10 %
of the cholesterol production .
Cholesterol is present in tissues & plasma either as : -Cholesterol is a 27 Carbon unit structure
Free cholesterol synthesized
It is in the ER cytosola begins
~
or &
Combined with
long chain FA Cholesteryl ester
. with Acetyl-CoA
~
In plasma both forms are transported in lipoproteins.
It is amphipathic lipid I The third reaction is the
~
~
has both
an polar rate-limiting step ; the
nonpolar ends reduction of HMG-CoA to mevalonate
It is synthesized in tissues from acetyl CoA En HMG CoA reductase
integral
~
membrane protein
many an
. .
,
It is the precursor of all other steroids in the body of the Smooth
~
this
,
ER . .
catalyzes step -
including corticosteroids , sex hormones , bile acids
& mmmm
vitamin D
. Summary :
cholesterol is found foods of animal .
1 Condensation of 3 acetyl to form 6)
in
origin
~
groups
. a
Cholesterol intermediate, mevalonate·
reaches the
tissues
through Plasma low
~
density lipoprotein LDG .
.
2 The conversion of mavelonate to activated
~
HDL removes cholesterol from tissues & transports it isoprene units .
to the liver where it is eliminated directly or converted 3 .
Polymerization of six 5-carbon isoprene
to bile acids first in the
process known as Reverse units to form the 30-c linear squalene
.
Cholesterol Transport Cyclization of squalene to form 4 of
rings
. 4
the steroid nucleus , with further series of
changes
oxidations, removal of
Extra cholesterol in bile lead to the formation of
migration
~
can or methyl groups
Gall stones to produce cholesterol .
levels of LDL of cholesteral contribute to the
High
~
mus
buildup of
plaque in arteries ,
leading to atherosclerosis , Cholesterol structure :
various cardiovascular diseases All sterols have 4 fused
which rings
~
can cause .
Card V diseases
. : Cerebrovascular , coronary & that form the steroid nucleus , with
peripheral vascular disease. a hydroxyl group at C-3 .
Half of the body's cholesterol is
~
Foo made
my day by
-
Synthesis , the rest comes from diet
The liver & intestine responsible for
~
are about 10 %
of the cholesterol production .
