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SLCC Pathophysiology Final Exam Questions

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abrasion - ANSWER Rubbing or scraping off of skin

angiogenesis - ANSWER formation of new blood vessels

approximation - ANSWER When wound edges are touching

avulsion - ANSWER tissue being torn away in a large piece. Requires healing by
secondary intention

Cellulitis - ANSWER Inflammation or infection of the cells in tissues characterized
by redness, pain, heat and edema.

debridement - ANSWER the removal of dirt, foreign objects, damaged tissue, and
cellular debris from a wound to prevent infection and to promote healing

dehiscence - ANSWER The splitting open of a surgical wound (usually one that
has been sutured)

Erythema - ANSWER redness of the skin due to capillary dilation

exudate - ANSWER fluid that comes from wounds

purulent - ANSWER Pus-like

sanguineous - ANSWER bloody drainage

granulation tissue - ANSWER the tissue that normally forms during the healing of a
wound

ischemia - ANSWER deficiency of blood in a particular area

laceration - ANSWER wound caused by tearing or cutting of skin

maceration - ANSWER softening through liquid; overhydration

necrotic tissue - ANSWER dead tissue that usually presents as black or brown and
is hard or leathery in texture. must be removed for wounds to heal.

Primary intention - ANSWER Wound margins are brought together by any means
and heals with minimal scarring.

,Secondary intention - ANSWER missing tissue requires margins to contract, and
then fill-ins, resulting a large scar. Cannot be sutured closed because too much
tissue is missing.

Tertiary intention healing - ANSWER Wound margins separate after being closed
or intentionally left open due to infection.

metastasize - ANSWER to spread by transferring a disease-causing agent from
the site of the disease to other parts of the body

benign cell characteristics - ANSWER well differentiated

benign cellular cohesiveness - ANSWER Stays together

benign growth mode - ANSWER expands and pushes on surrounding tissue

benign growth pattern - ANSWER encapsulated

benign growth rate - ANSWER generally slow growth

benign hormone secretion - ANSWER hyper

benign metastatic potential - ANSWER does not metastisize

benign tumor mobility - ANSWER movable

malignant cell characteristics - ANSWER poor differentiation

malignant cellular cohesiveness - ANSWER breaks apart, sluffs off easily

malignant growth mode - ANSWER infiltrates into tissue

malignant growth pattern - ANSWER infiltrates tissue

malignant growth rate - ANSWER usually rapid growth

malignant hormone secretion - ANSWER hypo

malignant metastatic potential - ANSWER eventually metastasizes

malignant tumor mobility - ANSWER fixed

differentiation - ANSWER process in which cells become specialized in structure
and function

cancer differentiation - ANSWER Tumors lose differentiation features over time as
they multiply and become more "malignant". The more these fast growing cells
multiply, the less differentiated they become. Poor cellular differentiation increases
the growth rate. A tumor neoplasm that is well differentiated (retains most of the
cellular characteristics of the tissue it is from) is more likely to be benign. Whereas, a

,poorly differentiated tumor is more likely to be malignant. As a cell becomes
malignant it loses the characteristics that made it a unique type of cell, and it no
longer functions as normal tissue

contact inhibition - ANSWER a process that stops additional cell growth when cells
become crowded

cohesiveness - ANSWER normal cell membranes stick together when they come
in contact helping support each other.

anchorage dependence - ANSWER The requirement that to divide, a cell must be
attached to a solid surface.

Faulty cell to cell communication - ANSWER Intracellular messengers cause
growth and modify behavior. Cancer cells don't listen to messengers and do what
they want.

antigens (cancer) - ANSWER surface cell markers

enzymes - ANSWER proteins involved in insuring intracellular organization and cell
to cell cohesion.

oma - ANSWER ending that indicates benign tumors

carcinoma - ANSWER epithelial origin named to indicate malignant tumors

sarcoma - ANSWER indicates malignant tumors in mesenchymal origin

mesenchymal - ANSWER connective tissue tumor

oncogenesis - ANSWER genetic mechanism where normal cells transform into
cancer cells

oncogene - ANSWER mutated gene that have potential to cause cancer

proto-oncogene - ANSWER genes that can become oncogenes

inherited genes or environmental mutations - ANSWER What can cause an
oncogene from a proto-oncogene

cellular oncogenes - ANSWER Cancer characteristics that are coded on the host's
inherited genes.

viral oncogenes - ANSWER DNA or RNA transmission into a host causing cancer

mutated antioncogene - ANSWER under production of cancer-preventing cells due
to mutation

antioncogene - ANSWER tumor suppressing genes

, direct extension, seeding, circulation - ANSWER methods of metastasis

direct extension - ANSWER cells spread to adjacent tissue

seeding - ANSWER Cells shed into body cavities or some cells remain after
removal that are the "seed" for more tumors

circulation - ANSWER travels through blood or lymph and a second tumor
develops in a completely different place

staging - ANSWER severity of cancer

size of tumor, node involvement, metastatic spread - ANSWER What does TNM
stand for?

TNM system - ANSWER What is used the most in cancer staging?

TX - ANSWER Primary tumor cannot be evaluated

T0 - ANSWER No evidence of primary tumor

Tis - ANSWER Carcinoma in situ

carcinoma in situ - ANSWER cancer in the early stage before invading surrounding
tissue

Size of the primary tumor - ANSWER T1 - 4 mean what in cancer?

NX - ANSWER lymph nodes cannot be evaluated

N0 - ANSWER No regional lymph node involvement

N1-3 - ANSWER Degree of lymph node involvement

MX - ANSWER distant metastasis that cannot be evaluated

M0 - ANSWER No distant metastasis

M1 - ANSWER Metastasis is present

Stage 1 - ANSWER In situ is considered what stage?

In situ - ANSWER When abnormal cell are present only in the layer of cells where
the tumor developed, what is it called?

localized - ANSWER Stage 2 of cancer

no evidence of spread - ANSWER What does is mean if a tumor is localized?

Regional - ANSWER What is stage 3 of cancer?

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