NAPLEX REVIEW PSYCH QUESTIONS
WITH 100% CORRECT ANSWERS {
GRADED A+}
What drugs can cause or worsen depression? - ✔✔Stratera, indomethacin, BB
(especially propranolol), contraceptives, anabolic steroids, antidepressants, BZD,
steroids, interferons, varenicline, ethanol
What is the only natural product that may have some benefit for depression -
✔✔St. Johns Wort
What is the preferred treatment if initiating antidepressant in pregnancy?
Breastfeeding? - ✔✔SSRI's except paroxetine (due to cardiac effects), but there is
a warning for increased risk of pulmonary HTN in newborn
SSRI's or TCA's (not doxepin)
, What are symptoms of serotonin syndrome? - ✔✔Nausea, dizziness, HA,
diarrhea, agitation, tachycardia, hallucinations, muscle rigidity
What is the only antidepressant that does not really need to be tapered due to long
half life? - ✔✔fluoxetine
When do you start to see improvement with antidepressants? - ✔✔1-2 weeks
physical improvements (energy), but psychological takes a month or more
SSRI MOA - ✔✔Increase 5-HT by inhibiting its reuptake in the neuronal synapse
What is the most stimulating SSRI? - ✔✔fluoxetine - take in AM
What is the most sedating SSRI? - ✔✔paroxetine - PM
Brisdelle - ✔✔paroxitene for menopausal symptoms
What SSRi is preferred in patients with cardiac risk? - ✔✔sertraline
What antibiotic has super high risk or serotonin syndrome? - ✔✔linezolid
What SSRI's increase QT the most? - ✔✔citalopram (max 40 mg/day) and
escitalopram (max 20 mg/day)
Vilazidone - ✔✔Viibryd - SSRI + partial 5-HT1A agonist (less sexual side
effects)
WITH 100% CORRECT ANSWERS {
GRADED A+}
What drugs can cause or worsen depression? - ✔✔Stratera, indomethacin, BB
(especially propranolol), contraceptives, anabolic steroids, antidepressants, BZD,
steroids, interferons, varenicline, ethanol
What is the only natural product that may have some benefit for depression -
✔✔St. Johns Wort
What is the preferred treatment if initiating antidepressant in pregnancy?
Breastfeeding? - ✔✔SSRI's except paroxetine (due to cardiac effects), but there is
a warning for increased risk of pulmonary HTN in newborn
SSRI's or TCA's (not doxepin)
, What are symptoms of serotonin syndrome? - ✔✔Nausea, dizziness, HA,
diarrhea, agitation, tachycardia, hallucinations, muscle rigidity
What is the only antidepressant that does not really need to be tapered due to long
half life? - ✔✔fluoxetine
When do you start to see improvement with antidepressants? - ✔✔1-2 weeks
physical improvements (energy), but psychological takes a month or more
SSRI MOA - ✔✔Increase 5-HT by inhibiting its reuptake in the neuronal synapse
What is the most stimulating SSRI? - ✔✔fluoxetine - take in AM
What is the most sedating SSRI? - ✔✔paroxetine - PM
Brisdelle - ✔✔paroxitene for menopausal symptoms
What SSRi is preferred in patients with cardiac risk? - ✔✔sertraline
What antibiotic has super high risk or serotonin syndrome? - ✔✔linezolid
What SSRI's increase QT the most? - ✔✔citalopram (max 40 mg/day) and
escitalopram (max 20 mg/day)
Vilazidone - ✔✔Viibryd - SSRI + partial 5-HT1A agonist (less sexual side
effects)
