USMLE UWORLD STEP 1 EXAM
2024/2025
USMLE UWORLD STEP 1 EXAM 2024/2025 WITH GUARANTEED ACCURATE
ANSWERS |VERIFIED
Pt had part of his small bowel surgically removed due to bowel ischemia and is
now receiving parenteral nutrition. He develops RUQ pain and N/V.
Diagnosis?
Pathogenesis? - ACCURATE ANSWER✅✅Cholesterol Gallstones
Form due to biliary/gallbladder stasis caused by decreased CCK release since
nutrition is not passing through the stomach/gut like normal
Standard Error (SE) vs. Standard Deviation (SD) - ACCURATE
ANSWER✅✅SE [= SD/sq.rt. (n)] is used to account for variability of sampling
(small sample sizes for studies) since an entire population is not studied at once
, Pt develops a gram-negative STI (Neisseria gonorrhoeae). The bacteria has an IgA
protease that splits IgA dimer (J chain). What is the role of this enzyme in the
infection? - ACCURATE ANSWER✅✅IgA antibodies bind to pili and
membrane proteins needed for bacterial adherence to mucosa, thus inhibiting
mucosal colonization. Thus, this enzyme facilitates mucosal adherance for the
bacteria.
16 y/o boy w/ mild intellectual disability is brought in for ADHD evaluation.
Parents said he had speech and motor delay as a child. PE shows a long narrow
face, prominent mandible & forehead, large testes, and joint hyperlaxity.
Diagnosis? Genetics? - ACCURATE ANSWER✅✅Fragile X Syndrome
X-linked (LOF mutation in FMR1 gene)
Clinical features are most apparent after puberty
What are the treatment options for Cyanide (CN) poisoning? MOA? - ACCURATE
ANSWER✅✅1. Nitrites (e.g. Amyl Nitrite)
MOA: induces methemoglobin formation (oxidizes ferrous iron to ferric iron),
which has a high affinity for CN so it sequesters it in the blood preventing it from
exerting its toxic effects on mitochondria
2. Sodium Thiosulfate
MOA: combines w/ CN to form the less toxic thiocyanate, which is excreted in the
urine
Cytosine deamination forms what base? What are the steps for DNA repair of this
type of damage? - ACCURATE ANSWER✅✅Cytosine deamination --> Uracil
2024/2025
USMLE UWORLD STEP 1 EXAM 2024/2025 WITH GUARANTEED ACCURATE
ANSWERS |VERIFIED
Pt had part of his small bowel surgically removed due to bowel ischemia and is
now receiving parenteral nutrition. He develops RUQ pain and N/V.
Diagnosis?
Pathogenesis? - ACCURATE ANSWER✅✅Cholesterol Gallstones
Form due to biliary/gallbladder stasis caused by decreased CCK release since
nutrition is not passing through the stomach/gut like normal
Standard Error (SE) vs. Standard Deviation (SD) - ACCURATE
ANSWER✅✅SE [= SD/sq.rt. (n)] is used to account for variability of sampling
(small sample sizes for studies) since an entire population is not studied at once
, Pt develops a gram-negative STI (Neisseria gonorrhoeae). The bacteria has an IgA
protease that splits IgA dimer (J chain). What is the role of this enzyme in the
infection? - ACCURATE ANSWER✅✅IgA antibodies bind to pili and
membrane proteins needed for bacterial adherence to mucosa, thus inhibiting
mucosal colonization. Thus, this enzyme facilitates mucosal adherance for the
bacteria.
16 y/o boy w/ mild intellectual disability is brought in for ADHD evaluation.
Parents said he had speech and motor delay as a child. PE shows a long narrow
face, prominent mandible & forehead, large testes, and joint hyperlaxity.
Diagnosis? Genetics? - ACCURATE ANSWER✅✅Fragile X Syndrome
X-linked (LOF mutation in FMR1 gene)
Clinical features are most apparent after puberty
What are the treatment options for Cyanide (CN) poisoning? MOA? - ACCURATE
ANSWER✅✅1. Nitrites (e.g. Amyl Nitrite)
MOA: induces methemoglobin formation (oxidizes ferrous iron to ferric iron),
which has a high affinity for CN so it sequesters it in the blood preventing it from
exerting its toxic effects on mitochondria
2. Sodium Thiosulfate
MOA: combines w/ CN to form the less toxic thiocyanate, which is excreted in the
urine
Cytosine deamination forms what base? What are the steps for DNA repair of this
type of damage? - ACCURATE ANSWER✅✅Cytosine deamination --> Uracil
