Test Bank For Goodman and Gilmans The Pharmacological
Basis of Therapeutics 13th Edition Brunton | 9781259584732 |
All Chapters with Answers and Rationals
Inhaled short acting Beta2 agonists such as Salbutamol produce which of the following effects?
(a) Bronchodilation
(b) Tightening of the airways
(c) Wheezing
(d) Cough - ANSWER: (A) bronchodilation
Olmesartan is an example of which of the following classes of medicine?
(a)Beta-blocker
(b) ACE Inhibitor
(c) Angiotensin II receptor antagonist
(d) Proton pump inhibitor - ANSWER: (c) Angiotensin II receptor antagonists
Conjugation reactions in the body generally result in a drug becoming:
(A) More lipophilic
(B) More toxic
(C) More polar and less toxic
(D) More hydrophobic - ANSWER: (C) More polar and less toxic
Which of the following is an example of a cytoprotective drug?
(A) Bismuth subsalicylate
(B) Diclofenac
(C) Domperidone
(D) Naproxen - ANSWER: (A) Bismuth subsalicylate
When used in the treatment of hypertension Bendroflumithiazide would normally be prescribed at a
dose of:
(A) 2.5mg in the morning
(B) 2.5mcg in the evening
(C) 5-10mg in the morning
(D) 5-10mg in the evening - ANSWER: (A) 2.5mg in the morning
Which of the following involves opening in response to a change in the membrane potential?
(A) G-Protein coupled receptors
(B) Voltage gated ion channels
(C) Kinase linked receptors
(D) Nuclear receptors - ANSWER: (B) Voltage gated ion channels
Which of the following is not considered a main side effect of Tricyclic Antidepressants (TCAs)?
(A) Dry mouth
(B) Urinary frequency
(C) Constipation
(D) Blurred vision - ANSWER: (B) Urinary frequency
The calcium channel blocker (CCB) Verapamil should not be prescribed with which other class of
drugs:
(A) ACE Inhibitors eg. Lisinopril (Zestril®).
(B) Beta Blockers eg. Metoprolol (Betaloc®)
(C) Cardiac Glyocsides eg. Digoxin (Lanoxin®)
(d) Angiotensin II Inhibitor eg. Valsartan (Diovan®) - ANSWER: (B) Beta Blockers. eg. Metoprolol
(Betaloc®)
, A PPI may be prescribed to a patient who is taking an NSAID (eg. Diclofenac) long term for what
reason?
(a) To enhance the action of the anti-inflammatory agent (NSAID)
(b) To aid in the NSAID's excretion
(C) Has no relationship to the NSAID being given at the same time
(D) To protect the gastric mucosa - ANSWER: (D) To protect the gastric mucosa
16% of body water is distributed into which compartment:
(a) Plasma
(b) Fat
(c) Interstitial
(d) Intracellular - ANSWER: (c) Interstitial
Which of the following statements about B-adrenoceptor blockers is correct?
(a) Lipophilic B-blockers are less likely to cause nightmares than hydrophilic B- blockers
(b) Cardio selective B-blockers have no effect on airways
(c) Non-selective B-blockers can cause coldness of the hands
(d) Are so specific for B-adrenoceptors in the heart they are referred to as cardio selective - ANSWER:
(c) Non-selective B-blockers can cause coldness of the hands
From the list below choose the diuretic, which is least likely to cause hypokalemia:
(A) Amiloride (Amilamont®)
(B) Frusemide (Lasix®)
(C) Bendroflumethiazide (Centyl®)
(D) Hydrochlorothiazide (Esidrix®) - ANSWER: (a) Amiloride (Amilamont®)
Which of the following is used to treat bronchial asthma?
(a) Beta2-adronoceptor antagonist
(b) Muscarinic antagonists
(c) Histamine H1-receptor blockers
(d) Proton Pump Inhibitors - ANSWER: (b) Muscarinic antagonists
5-20% of patients using ACE Inhibitors will suffer from nightmares which will require the patient to
return to their doctor for review and may result in a change in therapy.
(a) True
(b) False - ANSWER: (b) False
A patient's seizures are controlled by Phenobarbital. Which phase II reaction is induced by
Phenobarbital?
(a) Oxidation
(b) Hydrolysis
(c) Glucuronide Conjugation
(d) Reduction - ANSWER: (c) Glucuronide Conjugation
An example of a leukotriene receptor antagonist is ipratropium. (a) True (b) False - ANSWER: (b) False
The secretion of gastric hydrochloride can be inhibited by:
(a) Magnesium hydroxide
(b) Promethazine
(c) Ranitidine
(d) Ibuprofen - ANSWER: (c) Ranitidine
Which of the following drugs is a H2 receptor antagonist?
(a) Lansoprazole
(b) Famotidine
(c) Nifuroxazide
Basis of Therapeutics 13th Edition Brunton | 9781259584732 |
All Chapters with Answers and Rationals
Inhaled short acting Beta2 agonists such as Salbutamol produce which of the following effects?
(a) Bronchodilation
(b) Tightening of the airways
(c) Wheezing
(d) Cough - ANSWER: (A) bronchodilation
Olmesartan is an example of which of the following classes of medicine?
(a)Beta-blocker
(b) ACE Inhibitor
(c) Angiotensin II receptor antagonist
(d) Proton pump inhibitor - ANSWER: (c) Angiotensin II receptor antagonists
Conjugation reactions in the body generally result in a drug becoming:
(A) More lipophilic
(B) More toxic
(C) More polar and less toxic
(D) More hydrophobic - ANSWER: (C) More polar and less toxic
Which of the following is an example of a cytoprotective drug?
(A) Bismuth subsalicylate
(B) Diclofenac
(C) Domperidone
(D) Naproxen - ANSWER: (A) Bismuth subsalicylate
When used in the treatment of hypertension Bendroflumithiazide would normally be prescribed at a
dose of:
(A) 2.5mg in the morning
(B) 2.5mcg in the evening
(C) 5-10mg in the morning
(D) 5-10mg in the evening - ANSWER: (A) 2.5mg in the morning
Which of the following involves opening in response to a change in the membrane potential?
(A) G-Protein coupled receptors
(B) Voltage gated ion channels
(C) Kinase linked receptors
(D) Nuclear receptors - ANSWER: (B) Voltage gated ion channels
Which of the following is not considered a main side effect of Tricyclic Antidepressants (TCAs)?
(A) Dry mouth
(B) Urinary frequency
(C) Constipation
(D) Blurred vision - ANSWER: (B) Urinary frequency
The calcium channel blocker (CCB) Verapamil should not be prescribed with which other class of
drugs:
(A) ACE Inhibitors eg. Lisinopril (Zestril®).
(B) Beta Blockers eg. Metoprolol (Betaloc®)
(C) Cardiac Glyocsides eg. Digoxin (Lanoxin®)
(d) Angiotensin II Inhibitor eg. Valsartan (Diovan®) - ANSWER: (B) Beta Blockers. eg. Metoprolol
(Betaloc®)
, A PPI may be prescribed to a patient who is taking an NSAID (eg. Diclofenac) long term for what
reason?
(a) To enhance the action of the anti-inflammatory agent (NSAID)
(b) To aid in the NSAID's excretion
(C) Has no relationship to the NSAID being given at the same time
(D) To protect the gastric mucosa - ANSWER: (D) To protect the gastric mucosa
16% of body water is distributed into which compartment:
(a) Plasma
(b) Fat
(c) Interstitial
(d) Intracellular - ANSWER: (c) Interstitial
Which of the following statements about B-adrenoceptor blockers is correct?
(a) Lipophilic B-blockers are less likely to cause nightmares than hydrophilic B- blockers
(b) Cardio selective B-blockers have no effect on airways
(c) Non-selective B-blockers can cause coldness of the hands
(d) Are so specific for B-adrenoceptors in the heart they are referred to as cardio selective - ANSWER:
(c) Non-selective B-blockers can cause coldness of the hands
From the list below choose the diuretic, which is least likely to cause hypokalemia:
(A) Amiloride (Amilamont®)
(B) Frusemide (Lasix®)
(C) Bendroflumethiazide (Centyl®)
(D) Hydrochlorothiazide (Esidrix®) - ANSWER: (a) Amiloride (Amilamont®)
Which of the following is used to treat bronchial asthma?
(a) Beta2-adronoceptor antagonist
(b) Muscarinic antagonists
(c) Histamine H1-receptor blockers
(d) Proton Pump Inhibitors - ANSWER: (b) Muscarinic antagonists
5-20% of patients using ACE Inhibitors will suffer from nightmares which will require the patient to
return to their doctor for review and may result in a change in therapy.
(a) True
(b) False - ANSWER: (b) False
A patient's seizures are controlled by Phenobarbital. Which phase II reaction is induced by
Phenobarbital?
(a) Oxidation
(b) Hydrolysis
(c) Glucuronide Conjugation
(d) Reduction - ANSWER: (c) Glucuronide Conjugation
An example of a leukotriene receptor antagonist is ipratropium. (a) True (b) False - ANSWER: (b) False
The secretion of gastric hydrochloride can be inhibited by:
(a) Magnesium hydroxide
(b) Promethazine
(c) Ranitidine
(d) Ibuprofen - ANSWER: (c) Ranitidine
Which of the following drugs is a H2 receptor antagonist?
(a) Lansoprazole
(b) Famotidine
(c) Nifuroxazide
