By JoAnne Silbert Flagg | 9781975161064 | Chapter 1-56 | All
Chapters with Answers and Rationals
total volume of blood in the human body - ANSWER: - 85 ml/kg at birth
- 75 ml/kg at 6 months of age
- 70 ml/kg after the first year.
formation of blood cells begins at - ANSWER: early as week 2 of intrauterine life
by 2 months of intrauterine life, ____ begin forming blood components - ANSWER: spleen and liver
at 4 months, the ___ becomes and remains the active center of the origination of blood cells -
ANSWER: bone marrow
in the extrauterine life, the ___ serves as the organ for the destruction of the blood cells once their
normal lifetime has passed - ANSWER: spleen
blood plasma is consist of - ANSWER: proteins, hormones, enzymes, and electrolytes
Components of Blood Formation - ANSWER: 1. RBC
2. Hemoglobin
3. WBC
4. Platelets
function chiefly to transport oxygen to and carry carbon dioxide away from body cells. - ANSWER:
Erythrocyte (RBC)
formed in the bone marrow under the stimulation of _____, a hormone formed by the kidneys;
increased in production whenever a child has tissue hypoxia. - ANSWER: erythropoietin
overproduction of RBC; experienced by children with prolonged hypoxia. - ANSWER: Polycythemia
children with kidney disease have low RBC because of - ANSWER: inadequate erythropoietin secretion
in diseased kidneys
RBC form first as ____, then mature through ______ - ANSWER: erythroblasts; normoblast and
reticulocyte
at birth, infant has ___ RBC - ANSWER: 5 million RBC per cubic millimeter of blood
RBC component that allows to carry out the transport of O2 - ANSWER: hemoglobin
hemoglobin comprises _____ - ANSWER: - globin (protein dependent on nitrogen metabolism for its
formation)
- heme (iron-containing pigment)
___ portion that combines with O2 and CO2 for transport - ANSWER: heme
fetal hemoglobin is comprised of - ANSWER: 2 alpha and 2 gamma polypeptide chaines
adult hemoglobin (Hemoglobin A), a transition in 6 months, is comprised of - ANSWER: 2 alpha and 2
beta chains
, defects in beta chains - ANSWER: sickle cell anemia and thalassemia
Hemoglobin levels - ANSWER: at birth- 13.7 to 20.1 g/100 mL
3 months- 9.5 to 14.5 g/100 mL
puberty- 11 to 16 g/100 mL
average life span of RBC - ANSWER: 120 days
are nucleated cells and few in number compared with RBCs (there is approximately only 1 WBC to
every 500 RBCs) - ANSWER: Leukocytes
WBC life span varies from approximately - ANSWER: 6 hours to unknown intervals.
primary function is against antigen invasion - ANSWER: WBC
2 forms of WBC - ANSWER: 1. Granulocyte (w/ granules in cytoplasm)
2. Agranulocyte (w/o granules in cytoplasm)
kinds of granulocytes - ANSWER: 1. Neutrophil
2. Basophil
3. Eosinophils
kinds of agranulocytes - ANSWER: 1. Lymphocytes
2. Monocytes
total WBC count in newborns - ANSWER: 20, 000 per cubic millimeter
are round, non-nucleated bodies formed by the bone marrow; function is capillary hemostasis and
primary coagulation - ANSWER: Thrombocyte (platelets)
usual number of thrombocyte - ANSWER: is 150,000 to 300,000/mm3 after the first year.
immature thrombocytes - ANSWER: megakaryocytes
combination of blood and tissue factors released from the plasma (intrinsic pathway) releases -
ANSWER: factors VIII, IX, and XII
injured tissue (extrinsic pathway) releases - ANSWER: factor III, VII, and X
what are factors I, II, III, IV, V, and VII - ANSWER: I- fibrinogen
II- Prothrombin
III- Thromboplastin
IV- Calcium
V- Labile factor (Platelet Phospholipids)
VII- Stable Factor
what are factors VIII, IX, X, XI, XII, XIII - ANSWER: VIII- Antihemophilic Factor
IX- Christmas Factor; Antihemophilic factor B; Plasma thromboplastin component
X- Stuart Factor
XI- Plasma Thromboplastin antecedent (antihemophilic factor C)
XII- Hageman factor
XIII- Fibrin stabilizing Factor
first stage of clotting - ANSWER: injured vessel->vasoconstriction->platelet adhesion to damaged
vessel-> platelet plug formation