test bank cellular and molecular
immunology
The initiation of T cell responses requires multiple receptors on the T cells recognizing
ligands on APCs. The MHC molecule located around the peptide-binding cleft is
recognized by the: - answer-CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - answer-neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answer-recognize pathogen-associated molecular patterns
(PAMPs) on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing
ligands on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: -
answer-CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - answer-thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all
of the following molecules EXCEPT: - answer-MHC class II molecules
Immunologic memory refers to: - answer-changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - answer-L-selectin
The main consequences of complement activation are all of the following EXCEPT: -
answer-producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answer-dendritic cells
located mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B
lymphocyte zone) EXCEPT: - answer-short-lived plasma cells
The antigen recognition on the T cells is mediated by: - answer-the Variable (v) regions
of α and β chains
,The T-cell receptor: - answer-recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? -
answer-Clones of lymphocytes specific for antigens develop prior to exposure to the
antigens
The germinal centers found in the cortical region of lymph nodes and the peripheral
region of splenic periarteriolar lymphatic tissue: - answer-contains large populations of B
lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular
infections. Thus, in case of Mycobacterium leprae infection: - answer-tuberculoid
leprosy will occur in patients with a prominent TH1 response
Which of the following best describes the T-dependent antibody response? - answer-IT
is the response of follicular B lymphocytes to a protein antigen and characterized by
isotope-switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answer-One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all
of the following EXCEPT: - answer-antigen presentation to the T cells in the follicles of
the lymph nodes
The phases and order of the specific or acquired immune responses are: - answer-
recognition phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that
recruit and activate different cell types. The IFN-γ is produced mainly by: - answer-
CD4+ T cell TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the
macrophage and B lymphocytes by: - answer-CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D,
and J gene segments in different clones of lymphocytes is the result of: - answer-both
combinatorial diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: -
answer-recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal
was infected with rabies virus, is administration of human immunoglobulin preparations
containing anti-rabies virus antibodies. Which type of immunity would be established by
this treatment? - answer-passive humoral immunity
, The steps in the activation of T lymphocytes against a specific antigen takes place int
he following order: - answer-antigen recognition, activation, clonal expansion,
differentiation into effector cells & memory cells
Antigen recognition by T cells induces signal transduction through biochemical
intermediates which will activate enzymes responsible for activation of Transcriptional
Factors. This activation may be blocked by: - answer-cyclosporine
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell.
Caspase-activating proteins of the CTL granules are called: - answer-granzyme B
Regarding the recognition of microbes by innate immune system, all of the following are
true EXCEPT: - answer-the innate system responds more efficiently to each successive
encounter with a microbe
The adaptive immune system uses all of the following strategies to combat the majority
of microbes EXCEPT: - answer-many plasma proteins involved in host defense,
including the cytokines and interleukins, which are activated by microbes, and whose
products kill microbes
Which of the following receptors on the T cells is involved in signal transduction TO the
APCs? - answer-CD40 ligand
Regarding primary and secondary antibody responses, all of the following are true
EXCEPT: - answer-the lag period is shorter in the primary response
Which of the following functions DOES NOT occur in lymph nodes? - answer-blood
filtration of microbes
Which of the following is NOT true about the CD4 and CD8 cell markers? - answer-both
of the markers are present in the naive mature T-cell
Which of the following is NOT true of the ability of the T cell receptor (TCR) to
specifically recognize antigen? - answer-Only the alpha chain of the TCR is necessary
for antigen recognition
The majority of T lymphocytes recognize _______ antigens that are bound to and
displayed by the major histocompatibility complex (MHC) molecules of antigen-
presenting cells (APCs). - answer-protein
ß-2 microglobulin is an integral part of - answer-MHC class I molecule
CD40 Ligand (CD154) is expressed by which of the following cells? - answer-Activated
T cells
MHC class I molecules contain: - answer-One α and one ß-2 microglobulin
immunology
The initiation of T cell responses requires multiple receptors on the T cells recognizing
ligands on APCs. The MHC molecule located around the peptide-binding cleft is
recognized by the: - answer-CD4 or CD8 molecules
The edema occurring in the inflammatory process is the result of all the following factors
EXCEPT: - answer-neural impulse by the sympathetic system and vasoconstriction
Toll-Like Receptors (TLR): - answer-recognize pathogen-associated molecular patterns
(PAMPs) on selective microorganisms
The initiation of T cell responses requires multiple receptors on the T cells recognizing
ligands on APCs. The T cell receptor transduction molecule(s) is(are) conducted by: -
answer-CD3 and ζ molecules
Which of the following is considered a primary lymphoid organ? - answer-thymus
Immediate activation of the B lymphocytes following contact with the antigen involves all
of the following molecules EXCEPT: - answer-MHC class II molecules
Immunologic memory refers to: - answer-changes in adaptive immune responses with
subsequent encounters with antigen
Both, naive mature effector T lymphocytes migrate differently in their lives. Naive T cells
express which adhesion molecule to mediate their migration into lymph nodes through
specialized vessels called high endothelial venues (HEVs)? - answer-L-selectin
The main consequences of complement activation are all of the following EXCEPT: -
answer-producing 2nd signal for macrophage activation
'Langerhans Cells' which play a role in the immune system are: - answer-dendritic cells
located mainly in the epidermis
All of the following cells results in the germinal center reaction of the follicles (B
lymphocyte zone) EXCEPT: - answer-short-lived plasma cells
The antigen recognition on the T cells is mediated by: - answer-the Variable (v) regions
of α and β chains
,The T-cell receptor: - answer-recognizes antigen fragments via the α and β chains
According to the clonal selection hypothesis, which of the following is CORRECT? -
answer-Clones of lymphocytes specific for antigens develop prior to exposure to the
antigens
The germinal centers found in the cortical region of lymph nodes and the peripheral
region of splenic periarteriolar lymphatic tissue: - answer-contains large populations of B
lymphocytes and plasma cells
Balance between TH1 and TH2 cell activation determines outcome of intracellular
infections. Thus, in case of Mycobacterium leprae infection: - answer-tuberculoid
leprosy will occur in patients with a prominent TH1 response
Which of the following best describes the T-dependent antibody response? - answer-IT
is the response of follicular B lymphocytes to a protein antigen and characterized by
isotope-switched, high affinity antibodies; memory B cells, long lived plasma cells
MHC class II molecules contain: - answer-One α chain and one β chain
The inflammatory cytokines will cause Langerhans cells in the epidermis to perform all
of the following EXCEPT: - answer-antigen presentation to the T cells in the follicles of
the lymph nodes
The phases and order of the specific or acquired immune responses are: - answer-
recognition phase; activation phase; effector phase; homeostasis phase; memory phase
A naive CD4+ T cell may differentiate into subsets that produce different cytokines that
recruit and activate different cell types. The IFN-γ is produced mainly by: - answer-
CD4+ T cell TH1 subset
TH1 subset effector cells that aid in cell mediated immune response activate the
macrophage and B lymphocytes by: - answer-CD40L-CD40 interaction and IFN-γ
The diversity of antigen receptors produced by the use of different combinations of V, D,
and J gene segments in different clones of lymphocytes is the result of: - answer-both
combinatorial diversity and junctional diversity
All of the following statements about the B-cell antigen receptor are true EXCEPT: -
answer-recognizes antigen fragments via the α and β chains
A standard treatment of animal bite victims, when there is a possibility that the animal
was infected with rabies virus, is administration of human immunoglobulin preparations
containing anti-rabies virus antibodies. Which type of immunity would be established by
this treatment? - answer-passive humoral immunity
, The steps in the activation of T lymphocytes against a specific antigen takes place int
he following order: - answer-antigen recognition, activation, clonal expansion,
differentiation into effector cells & memory cells
Antigen recognition by T cells induces signal transduction through biochemical
intermediates which will activate enzymes responsible for activation of Transcriptional
Factors. This activation may be blocked by: - answer-cyclosporine
The CD8+ cytolytic T lymphocyte (CTL) uses different mechanisms to kill the target cell.
Caspase-activating proteins of the CTL granules are called: - answer-granzyme B
Regarding the recognition of microbes by innate immune system, all of the following are
true EXCEPT: - answer-the innate system responds more efficiently to each successive
encounter with a microbe
The adaptive immune system uses all of the following strategies to combat the majority
of microbes EXCEPT: - answer-many plasma proteins involved in host defense,
including the cytokines and interleukins, which are activated by microbes, and whose
products kill microbes
Which of the following receptors on the T cells is involved in signal transduction TO the
APCs? - answer-CD40 ligand
Regarding primary and secondary antibody responses, all of the following are true
EXCEPT: - answer-the lag period is shorter in the primary response
Which of the following functions DOES NOT occur in lymph nodes? - answer-blood
filtration of microbes
Which of the following is NOT true about the CD4 and CD8 cell markers? - answer-both
of the markers are present in the naive mature T-cell
Which of the following is NOT true of the ability of the T cell receptor (TCR) to
specifically recognize antigen? - answer-Only the alpha chain of the TCR is necessary
for antigen recognition
The majority of T lymphocytes recognize _______ antigens that are bound to and
displayed by the major histocompatibility complex (MHC) molecules of antigen-
presenting cells (APCs). - answer-protein
ß-2 microglobulin is an integral part of - answer-MHC class I molecule
CD40 Ligand (CD154) is expressed by which of the following cells? - answer-Activated
T cells
MHC class I molecules contain: - answer-One α and one ß-2 microglobulin
