Test Bank For Pharmacology for Canadian Health Care
Practice 3rd Edition By Lilley ALL Chapters .
When is drug transfer to the fetus most likely to occur? - ANSWER: Last trimester
When is the fetus more susceptible to developing birth defects due to drugs or chemicals the mother
is exposed to? - ANSWER: First trimester
During the spectrum of life, when is there an increased risk of adverse affects to toxicity? - ANSWER:
At both ends of the spectrum; the very young and the very old
True or False: Breast fed infants are at risk for exposure to drugs consumed by the mother - ANSWER:
True
What is the general gastric pH for ages 1-12 - ANSWER: less acidic
in neonatal and pediatrics, how is their gastric emptying compared to adults? - ANSWER: slowed
in neonatal and pediatrics, how is their first-pass elimination compared to adults? - ANSWER: first-
pass elimination reduced
in neonatal and pediatrics, how is their IM absorption compared to adults? - ANSWER: Faster and
irregular
Fill the blanks: in neonatal and pediatrics, ___________________ bile salt formation
___________________ bioavailability. - ANSWER: reduced, decreases
Do neonates and pediatric patients have a higher or lower TBW? - ANSWER: Higher
What does total body water in neonates and pediatrics result in when given a water soluble drug? -
ANSWER: Increased distribution and dilution
in neonatal and pediatrics, what is the level of protein binding compared to an adult? - ANSWER:
Decreased
Immature blood-brain barrier means... - ANSWER: More drugs enter the brain
in the immature liver, what does it not produce enough of? - ANSWER: Microsomal enzymes
(cytochrome P450; P450 enzymes)
Older children may have increased metabolism, what would they require with drug administration but
not with infants? - ANSWER: Higher doses or more frequent administration
With an immature liver, what is an infant at risk of when given drugs? - ANSWER: Pediatric drug
toxicity
Fill the blanks: Kidney immaturity affects _________________ and ____________________. -
ANSWER: glomerular filtration rate, tubular secretion
Decreased perfusion rate of the kidneys may... - ANSWER: reduce excretion of drugs
Factors affecting pediatric drug dosage - ANSWER: -Skin is thin and permeable
-Stomach lacks acid to kill bacteria
-Lungs have weaker mucus barriers
-Body temperatures less well regulated, and dehydration occurs easily
Practice 3rd Edition By Lilley ALL Chapters .
When is drug transfer to the fetus most likely to occur? - ANSWER: Last trimester
When is the fetus more susceptible to developing birth defects due to drugs or chemicals the mother
is exposed to? - ANSWER: First trimester
During the spectrum of life, when is there an increased risk of adverse affects to toxicity? - ANSWER:
At both ends of the spectrum; the very young and the very old
True or False: Breast fed infants are at risk for exposure to drugs consumed by the mother - ANSWER:
True
What is the general gastric pH for ages 1-12 - ANSWER: less acidic
in neonatal and pediatrics, how is their gastric emptying compared to adults? - ANSWER: slowed
in neonatal and pediatrics, how is their first-pass elimination compared to adults? - ANSWER: first-
pass elimination reduced
in neonatal and pediatrics, how is their IM absorption compared to adults? - ANSWER: Faster and
irregular
Fill the blanks: in neonatal and pediatrics, ___________________ bile salt formation
___________________ bioavailability. - ANSWER: reduced, decreases
Do neonates and pediatric patients have a higher or lower TBW? - ANSWER: Higher
What does total body water in neonates and pediatrics result in when given a water soluble drug? -
ANSWER: Increased distribution and dilution
in neonatal and pediatrics, what is the level of protein binding compared to an adult? - ANSWER:
Decreased
Immature blood-brain barrier means... - ANSWER: More drugs enter the brain
in the immature liver, what does it not produce enough of? - ANSWER: Microsomal enzymes
(cytochrome P450; P450 enzymes)
Older children may have increased metabolism, what would they require with drug administration but
not with infants? - ANSWER: Higher doses or more frequent administration
With an immature liver, what is an infant at risk of when given drugs? - ANSWER: Pediatric drug
toxicity
Fill the blanks: Kidney immaturity affects _________________ and ____________________. -
ANSWER: glomerular filtration rate, tubular secretion
Decreased perfusion rate of the kidneys may... - ANSWER: reduce excretion of drugs
Factors affecting pediatric drug dosage - ANSWER: -Skin is thin and permeable
-Stomach lacks acid to kill bacteria
-Lungs have weaker mucus barriers
-Body temperatures less well regulated, and dehydration occurs easily
