BBH 451 Midterm Exam Questions and
Correct Answers
Cocaine sympathomimetics (stimulant) ✅intranasal
(50 min)
Metabolized by: butyrylcholinesterase
Metabolite: benzoylecgonine
Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Sympathomimetics (stimulant)
Replacement or substitution therapy
Bruxism, gum disease, cardiovascular effects
Cocaine is primary taken? ✅intranasal
Cocaine's half-life ✅50 min
Cocaine is metabolized by ✅butyrlcholinesterase
Metabolite: benzoylecgonine
Cocaine's mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Cocaine's side effects ✅bruxism, gum disease, cardiovascular effects
Cocaine's addiction therapy ✅replacement or substitution therapy
Amphetamine sympathomimetics (stimulant) ✅isomer/ d-amphetamine l-amphetamine
Oral and intranasal (recreationally)
(10 hours)
Metabolized by: p450 enzyme (CYP2D6)
Metabolite: alpha-hydroxy-amphetamine
, Mechanism of action:
Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Inhibits VMAT-2 (neurotransmitters into vesicles)
Increased release of dopamine, norepinephrine, serotonin
ADHD treatment:
Adderall, lisdexamfetamine, methylphenidate (ritalin)
Stimulant psychosis, overdose, cardiovascular disease
Amphetamine is taken primarily? ✅oral and intranasal (recreational)
Amphetamines half-life? ✅10 hours
Amphetamines are metabolized by? ✅p450 enzyme - CYP2D6
Metabolite: alpha-hydroxy-amphetamine
Amphetamine mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Inhibits VMAT-2 (neurotransmitters into vesicles)
Increased release of dopamine, norepinephrine, serotonin
Amphetamine ADHD treatment ✅adderall, lisdexfetamine, methylphenidate
Amphetamine side effects ✅stimulant psychosis, overdose, cardiovascular disease
Amphetamine isomer ✅d-amphetamine
L-amphetamine - racemic mixture
Methamphetamine ✅isomer/ d-methamphetamine l-methamphetamine
Intranasal, inhalation, injection
(up to 30 hours)
Metabolized by: p450 enzyme (CYP2D6)
Correct Answers
Cocaine sympathomimetics (stimulant) ✅intranasal
(50 min)
Metabolized by: butyrylcholinesterase
Metabolite: benzoylecgonine
Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Sympathomimetics (stimulant)
Replacement or substitution therapy
Bruxism, gum disease, cardiovascular effects
Cocaine is primary taken? ✅intranasal
Cocaine's half-life ✅50 min
Cocaine is metabolized by ✅butyrlcholinesterase
Metabolite: benzoylecgonine
Cocaine's mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Cocaine's side effects ✅bruxism, gum disease, cardiovascular effects
Cocaine's addiction therapy ✅replacement or substitution therapy
Amphetamine sympathomimetics (stimulant) ✅isomer/ d-amphetamine l-amphetamine
Oral and intranasal (recreationally)
(10 hours)
Metabolized by: p450 enzyme (CYP2D6)
Metabolite: alpha-hydroxy-amphetamine
, Mechanism of action:
Inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Inhibits VMAT-2 (neurotransmitters into vesicles)
Increased release of dopamine, norepinephrine, serotonin
ADHD treatment:
Adderall, lisdexamfetamine, methylphenidate (ritalin)
Stimulant psychosis, overdose, cardiovascular disease
Amphetamine is taken primarily? ✅oral and intranasal (recreational)
Amphetamines half-life? ✅10 hours
Amphetamines are metabolized by? ✅p450 enzyme - CYP2D6
Metabolite: alpha-hydroxy-amphetamine
Amphetamine mechanism of action ✅inhibits (blocking) the reuptake:
Dopamine, norepinephrine, serotonin
Inhibits VMAT-2 (neurotransmitters into vesicles)
Increased release of dopamine, norepinephrine, serotonin
Amphetamine ADHD treatment ✅adderall, lisdexfetamine, methylphenidate
Amphetamine side effects ✅stimulant psychosis, overdose, cardiovascular disease
Amphetamine isomer ✅d-amphetamine
L-amphetamine - racemic mixture
Methamphetamine ✅isomer/ d-methamphetamine l-methamphetamine
Intranasal, inhalation, injection
(up to 30 hours)
Metabolized by: p450 enzyme (CYP2D6)
