BBL MODULE 2 QUESTIONS AND
VERIFIED ANSWERS|100%
CORRECT|GRADE A+
Proteins - ANSWER linear hetero-polymers of alpha-amino acids bound by covalent peptide bonds
macromolecules that catalyze metabolic reactions, replicate DNA, respond to stimuli, and transport
molecules from one location to another
What is the native configuration, and what is it held by? - ANSWER -the specific 3D shape of the protein
held by weak interactions such as:
hydrogen bonding
salt bridges
disulfide bonds (in secreted proteins)
What occurs when a protein is folded into the native fold? - ANSWER There is a cost in conformational
entropy
What are the native fold interactions within a protein? - ANSWER hydrophobic effect-> release of water
increases entropy
hydrogen bonds in alpha and beta sheets
london dispersion
electrostatic interactions between charged groups (salt bridges)
Where does peptide synthesis occur? - ANSWER on the ribosome
What does peptide bond resonance do? - ANSWER causes the peptide bond to be rigid and planar
, also sets up a small electric dipole in the protein in the TRANS configuration
What amino acid is able to be in the cis position and how does this occur? - ANSWER Proline cis-trans
isomerization occurs due to peptidyl prolyl isomerase
Ramachandran plot - ANSWER give the distributions of the phi and psi bonds that are found in a protein
-shows what secondary structures are most likely going to be found within an amino acid chain
What is the alpha-helix backbone held by? - ANSWER held by hydrogen bonds between backbone
amides of the n amino acid and the n+4 amino acid carbonyl oxygen
Right-handed alpha-helix is ___ residues per turn - ANSWER 3.6 residues (5.4A)
peptide bonds are ____ to helical axis - ANSWER parallel
side chains are _____ to helical axis - ANSWER perpendicular
What is the inner diameter of the helix with no side chains - ANSWER 4-5A which is too mall to fit
anything inside
What is the outer diameter of the helix with side chains - ANSWER 10-12A
residues 1 and 8 align on top of each other
How much bond energy does hydrogen bonding give to the folded protein - ANSWER 12kj/mol
What are strong helix formers? - ANSWER Alanine and Leucine
they have small hydrophobic residues
VERIFIED ANSWERS|100%
CORRECT|GRADE A+
Proteins - ANSWER linear hetero-polymers of alpha-amino acids bound by covalent peptide bonds
macromolecules that catalyze metabolic reactions, replicate DNA, respond to stimuli, and transport
molecules from one location to another
What is the native configuration, and what is it held by? - ANSWER -the specific 3D shape of the protein
held by weak interactions such as:
hydrogen bonding
salt bridges
disulfide bonds (in secreted proteins)
What occurs when a protein is folded into the native fold? - ANSWER There is a cost in conformational
entropy
What are the native fold interactions within a protein? - ANSWER hydrophobic effect-> release of water
increases entropy
hydrogen bonds in alpha and beta sheets
london dispersion
electrostatic interactions between charged groups (salt bridges)
Where does peptide synthesis occur? - ANSWER on the ribosome
What does peptide bond resonance do? - ANSWER causes the peptide bond to be rigid and planar
, also sets up a small electric dipole in the protein in the TRANS configuration
What amino acid is able to be in the cis position and how does this occur? - ANSWER Proline cis-trans
isomerization occurs due to peptidyl prolyl isomerase
Ramachandran plot - ANSWER give the distributions of the phi and psi bonds that are found in a protein
-shows what secondary structures are most likely going to be found within an amino acid chain
What is the alpha-helix backbone held by? - ANSWER held by hydrogen bonds between backbone
amides of the n amino acid and the n+4 amino acid carbonyl oxygen
Right-handed alpha-helix is ___ residues per turn - ANSWER 3.6 residues (5.4A)
peptide bonds are ____ to helical axis - ANSWER parallel
side chains are _____ to helical axis - ANSWER perpendicular
What is the inner diameter of the helix with no side chains - ANSWER 4-5A which is too mall to fit
anything inside
What is the outer diameter of the helix with side chains - ANSWER 10-12A
residues 1 and 8 align on top of each other
How much bond energy does hydrogen bonding give to the folded protein - ANSWER 12kj/mol
What are strong helix formers? - ANSWER Alanine and Leucine
they have small hydrophobic residues
