BBL MODULES 1 – 5 QUESTIONS AND
VERIFIED ANSWERS|100%
CORRECT|GRADE A+
Alanine has a pK1 and pK2 while lysine has a pK1, pK2 and a pKR. Why? - ANSWER The R group of
alanine is non-polar while lysine has a charged R group
All amino acids are formed by the amination of? - ANSWER Keto Acids
All amino acids are made from the intermediates from which metabolic pathways? - ANSWER Glycolysis
Pentose phosphate pathway
TCA/citric acid cycle
All amino acids have an R group. What is the significance of the R? - ANSWER Each of the 21 amino
amino acids has a unique R group
All amino acids have chiral centers except which amino acid? - ANSWER Glycine
All naturally occurring amino acids are in what stereochemical confirmation? - ANSWER L- amino acids
Amino acids are classified according to what? - ANSWER Side chain R groups
Amino acids play a role in buffering what biological components? - ANSWER Cells and Blood
An amino acid without an ionizable R group will be electrically ____? - ANSWER Neutral
At neutral pH, all amino acids are? - ANSWER Zwitterionic, with both the amine and carboxylic acid
charged
At physiological pH (~7), what is the net charge of amino acids? - ANSWER 0
,At physiological pH, the amine group will be protonated or unprotonated? - ANSWER protonated
At physiological pH, the carboxylic acid group will be protonated or unprotonated? - ANSWER
unprotonated
Based on charge, the largest group of amino acids is? - ANSWER Non-polar
High levels of desmosine in blood indicate? - ANSWER High elastase activity
How does the amine base of the amino acid become a conjugate acid? - ANSWER It becomes protonated
by gaining an H+ ion
How is carboxyglutamic acid amino acid made? - ANSWER post translational carboxylation of glutamic
acid
If pH is less than the pKa, what will be the protonation status of the majority of the species? - ANSWER
protonated
If pH is more than the pKa, what will be the protonation status of the majority of the species? - ANSWER
deprotonated
In a titration curve, each step represents what? - ANSWER Titration of each proton
Methionine is adenylated by which enzyme? - ANSWER S adenosylmethionine synthase
Nitrogen enters the anabolic pathways of all amino acids as? - ANSWER Glutamate and Glutamine
Of the 20 amino acids, how many do not ionize? - ANSWER 13
, Ornithine condenses with carmayl phosphate to form? - ANSWER Citrulline
R and S amino acid classification refers to what? - ANSWER 3D structure of amino acids
Based on ranking of functional groups and what direction they go
The isoelectric point (pI) of a non-polar amino acid is the pH where? - ANSWER Both amine and
carboxylic acids are charged and the amino acid has zero net charge
The major metabolic source of amino acid precursors is? - ANSWER TCA Cycle
The major use of methionine is in (besides being start codon for protein synthesis)? - ANSWER
Adenylation of methionine by ATP for form S adenosylmethionine (SAM
The uncommon amino acid ornithine is? - ANSWER Starting substrate of the urea cycle
The unique amino acid found in the elastin protein is? - ANSWER Desmosine
What amino acids have pKR in the acid range? - ANSWER Glutamate and aspartate (negatively charged
amino acids)
What are enantiomers? - ANSWER non superimposible mirror images
What are possible amino acid post-translational modifications? - ANSWER Phosphorylation
Glycosylation
Methylation
Acetylation
Ubiquitination
Farnesylation
VERIFIED ANSWERS|100%
CORRECT|GRADE A+
Alanine has a pK1 and pK2 while lysine has a pK1, pK2 and a pKR. Why? - ANSWER The R group of
alanine is non-polar while lysine has a charged R group
All amino acids are formed by the amination of? - ANSWER Keto Acids
All amino acids are made from the intermediates from which metabolic pathways? - ANSWER Glycolysis
Pentose phosphate pathway
TCA/citric acid cycle
All amino acids have an R group. What is the significance of the R? - ANSWER Each of the 21 amino
amino acids has a unique R group
All amino acids have chiral centers except which amino acid? - ANSWER Glycine
All naturally occurring amino acids are in what stereochemical confirmation? - ANSWER L- amino acids
Amino acids are classified according to what? - ANSWER Side chain R groups
Amino acids play a role in buffering what biological components? - ANSWER Cells and Blood
An amino acid without an ionizable R group will be electrically ____? - ANSWER Neutral
At neutral pH, all amino acids are? - ANSWER Zwitterionic, with both the amine and carboxylic acid
charged
At physiological pH (~7), what is the net charge of amino acids? - ANSWER 0
,At physiological pH, the amine group will be protonated or unprotonated? - ANSWER protonated
At physiological pH, the carboxylic acid group will be protonated or unprotonated? - ANSWER
unprotonated
Based on charge, the largest group of amino acids is? - ANSWER Non-polar
High levels of desmosine in blood indicate? - ANSWER High elastase activity
How does the amine base of the amino acid become a conjugate acid? - ANSWER It becomes protonated
by gaining an H+ ion
How is carboxyglutamic acid amino acid made? - ANSWER post translational carboxylation of glutamic
acid
If pH is less than the pKa, what will be the protonation status of the majority of the species? - ANSWER
protonated
If pH is more than the pKa, what will be the protonation status of the majority of the species? - ANSWER
deprotonated
In a titration curve, each step represents what? - ANSWER Titration of each proton
Methionine is adenylated by which enzyme? - ANSWER S adenosylmethionine synthase
Nitrogen enters the anabolic pathways of all amino acids as? - ANSWER Glutamate and Glutamine
Of the 20 amino acids, how many do not ionize? - ANSWER 13
, Ornithine condenses with carmayl phosphate to form? - ANSWER Citrulline
R and S amino acid classification refers to what? - ANSWER 3D structure of amino acids
Based on ranking of functional groups and what direction they go
The isoelectric point (pI) of a non-polar amino acid is the pH where? - ANSWER Both amine and
carboxylic acids are charged and the amino acid has zero net charge
The major metabolic source of amino acid precursors is? - ANSWER TCA Cycle
The major use of methionine is in (besides being start codon for protein synthesis)? - ANSWER
Adenylation of methionine by ATP for form S adenosylmethionine (SAM
The uncommon amino acid ornithine is? - ANSWER Starting substrate of the urea cycle
The unique amino acid found in the elastin protein is? - ANSWER Desmosine
What amino acids have pKR in the acid range? - ANSWER Glutamate and aspartate (negatively charged
amino acids)
What are enantiomers? - ANSWER non superimposible mirror images
What are possible amino acid post-translational modifications? - ANSWER Phosphorylation
Glycosylation
Methylation
Acetylation
Ubiquitination
Farnesylation
