BBL LESSON 17: BIOMINERALIZATION
QUESTIONS AND VERIFIED
ANSWERS|100% CORRECT|GRADE A+
Hydroxyapatite crystal size is inversely proportional to the
A. rate of matrix vesicle rupture
B. rate of crystal formation
C. rate of Type I collagen fibril formation
D. rate of SIBLING protease cleavage - ANSWER B. rate of crystal formation
Where is ACP forming during the biomineralization of dentin and bone?
A. matrix vesicles of both the odontoblast and ameloblast
B. matrix vesicles of the odontoblast and osteoblast
C. matrix vesicles of the ameloblast
D. within Type I collagen fibrils - ANSWER B. matrix vesicles of the odontoblast and osteoblast
Hydroxyapatite is
A. highly crystalline, highly ordered, and non-porous
B. comprised of calcium, phosphate and high sulfate content
C. easily dissolved by acid
D. not very wear resistant
E. all of the above - ANSWER A. highly crystalline, highly ordered, and non-porous
True or False: Type I collagen controls the direction of HAP crystal growth - ANSWER True
True or False: SIBLINGS and proteoglycans control HAP crystal size - ANSWER True
, True or False: Matrix vesicles act as a delivery system for transporting ACP, proteins, and proteoglycans
to the extracellular matrix - ANSWER False
True or False: Dentin-generating tissues derive from mesenchyme - ANSWER True
What is the first step in the biomineralization process?
A. ECM self-assembly and mineral maturation occur
B. Mineral and ECM components are transported to the boundary space
C. Cells become synthetically active, mineral precursors and ECM components are made
D. Cells organize together to create a boundary space - ANSWER D. Cells organize together to create a
boundary space
Which genes are implicated in the disease amelogenesis imperfecta?
A. ENAM, AMELX, TUFT1
B. AMBN, AMTN, AMELX
C. ENAM, AMTN, TUFT1
D. AMELX, AMBN, ENAM - ANSWER A. ENAM, AMELX, TUFT1
With regard to tissue engineering of bone, what are the major drawbacks of synthetic bone replacement
materials?
A. They are difficult to stabilize within large bone defect sites
B. Remodeling of replacement materials may be slow relative to autografts
C. In the case of bioactive glasses, they are typically brittle in nature
D. All of the above - ANSWER D. All of the above
Osteoporosis results in the net loss of bone matrix. This happens due to
QUESTIONS AND VERIFIED
ANSWERS|100% CORRECT|GRADE A+
Hydroxyapatite crystal size is inversely proportional to the
A. rate of matrix vesicle rupture
B. rate of crystal formation
C. rate of Type I collagen fibril formation
D. rate of SIBLING protease cleavage - ANSWER B. rate of crystal formation
Where is ACP forming during the biomineralization of dentin and bone?
A. matrix vesicles of both the odontoblast and ameloblast
B. matrix vesicles of the odontoblast and osteoblast
C. matrix vesicles of the ameloblast
D. within Type I collagen fibrils - ANSWER B. matrix vesicles of the odontoblast and osteoblast
Hydroxyapatite is
A. highly crystalline, highly ordered, and non-porous
B. comprised of calcium, phosphate and high sulfate content
C. easily dissolved by acid
D. not very wear resistant
E. all of the above - ANSWER A. highly crystalline, highly ordered, and non-porous
True or False: Type I collagen controls the direction of HAP crystal growth - ANSWER True
True or False: SIBLINGS and proteoglycans control HAP crystal size - ANSWER True
, True or False: Matrix vesicles act as a delivery system for transporting ACP, proteins, and proteoglycans
to the extracellular matrix - ANSWER False
True or False: Dentin-generating tissues derive from mesenchyme - ANSWER True
What is the first step in the biomineralization process?
A. ECM self-assembly and mineral maturation occur
B. Mineral and ECM components are transported to the boundary space
C. Cells become synthetically active, mineral precursors and ECM components are made
D. Cells organize together to create a boundary space - ANSWER D. Cells organize together to create a
boundary space
Which genes are implicated in the disease amelogenesis imperfecta?
A. ENAM, AMELX, TUFT1
B. AMBN, AMTN, AMELX
C. ENAM, AMTN, TUFT1
D. AMELX, AMBN, ENAM - ANSWER A. ENAM, AMELX, TUFT1
With regard to tissue engineering of bone, what are the major drawbacks of synthetic bone replacement
materials?
A. They are difficult to stabilize within large bone defect sites
B. Remodeling of replacement materials may be slow relative to autografts
C. In the case of bioactive glasses, they are typically brittle in nature
D. All of the above - ANSWER D. All of the above
Osteoporosis results in the net loss of bone matrix. This happens due to
