©THEBRIGHT EXAM STUDY SOLUTIONS 8/22/2024 12:54 PM
Janeway's Immunobiology: Chapter 6 Exam
Questions And Correct Answers
Describes two individuals or two mouse strains that differ at genes in the MHC. The term can
also be used for allelic differences at other loci. - answer✔✔allogeneic
The recognition by T cells of MHC molecules other than self. Such responses are also called
alloreactions or alloreactive responses. - answer✔✔alloreactivity (adj. alloreactive)
The display of antigen on the surface of a cell in the form of peptide fragments bound to MHC
molecules. T cells recognize antigen when it is presented in this way. - answer✔✔antigen
presentation
The intracellular degradation of foreign proteins into peptides that can bind to MHC molecules
for presentation to T cells. All protein antigens must be processed into peptides before they can
be presented by MHC molecules. - answer✔✔antigen processing
The digestion and breakdown by a cell of its own organelles and proteins in lysosomes. It may be
one route by which cytosolic proteins can be processed for presentation on MHC class II
molecules. - answer✔✔autophagy
A chaperone protein in the endoplasmic reticulum (ER) that binds to partly folded members of
the immunoglobulin superfamily of proteins and retains them in the ER until folding is complete.
- answer✔✔calnexin
A chaperone protein in the endoplasmic reticulum that, together with ERp57 and tapasin, forms
the peptide-loading complex that loads peptides onto newly synthesized MHC class I molecules.
- answer✔✔calreticulin
Small family of MHC class I-like proteins that are not encoded in the MHC and can present
glycolipid antigens to CD4 T cells. - answer✔✔CD1
A peptide of variable length cleaved from the invariant chain (Ii) by proteases. It remains
associated with the MHC class II molecule in an unstable form until it is removed by the HLA-
DM protein. - answer✔✔class II-associated invariant chain peptide (CLIP)
, ©THEBRIGHT EXAM STUDY SOLUTIONS 8/22/2024 12:54 PM
Describes the situation in which the two alleles of a gene are expressed in roughly equal amounts
in the heterozygote. Most genes show this property, including the highly polymorphic MHC
genes. - answer✔✔codominant
The process by which extracellular proteins taken up by dendritic cells can give rise to peptides
presented by MHC class I molecules. It enables antigens from extracellular sources to be
presented by MHC class I molecules and activate CD8 T cells. - answer✔✔cross-presentation
Peptides translated from introns in improperly spliced mRNAs, translations of frameshifts, and
improperly folded proteins, which are recognized and tagged by ubiquitin for rapid degradation
by the proteasome. - answer✔✔defective ribosomal products (DRiP's)
In reference to viral defense mechanisms, the degradation of newly synthesized MHC class I
molecules by viral proteins. - answer✔✔dislocation
The subset of differentiated effector T cells carrying the CD4 co-receptor molecule, which
includes the TH1, TH2, TH17, and regulatory T cells. - answer✔✔effector CD4 T cells
Enzyme in the endoplasmic reticulum that trims polypeptides to a size at which they can bind to
MHC class I molecules. - answer✔✔endoplasmic reticulum aminopeptidase associated with
antigen processing (ERAAP)
Membrane-enclosed intracellular vesicles in which material is carried from and to the cell
exterior. Antigen taken up by phagocytosis generally enters the endosomal system. -
answer✔✔endosomes
A chaperone protein involved in loading peptide onto MHC class I molecules in the endoplasmic
reticulum. - answer✔✔Erp57
A linked set of genes on a chromosome that are typically inherited without undergoing
recombination. The term is used mainly in connection with the linked genes of the major
histocompatibility complex (MHC), which is usually inherited as one haplotype from each
parent. - answer✔✔haplotype
Describes individuals that have two different alleles of a given gene, one inherited from the
mother and one from the father. - answer✔✔heterozygous
The ability of tissues from one individual to be accepted (histocompatible tissues) or rejected
(histoincompatible tissues) if transplanted to another individual. - answer✔✔histocompatibility
Any tissue antigens that provoke an immune response in a genetically nonidentical member of
the same species. The major histocompatibility antigens, also known as MHC molecules, are
encoded in the MHC, and are also the molecules that present foreign peptides to T cells. Minor
histocompatibility antigens comprise other polymorphic proteins that can be recognized as
foreign by an unrelated individual. - answer✔✔histocompatibility antigens (H antigens)
Janeway's Immunobiology: Chapter 6 Exam
Questions And Correct Answers
Describes two individuals or two mouse strains that differ at genes in the MHC. The term can
also be used for allelic differences at other loci. - answer✔✔allogeneic
The recognition by T cells of MHC molecules other than self. Such responses are also called
alloreactions or alloreactive responses. - answer✔✔alloreactivity (adj. alloreactive)
The display of antigen on the surface of a cell in the form of peptide fragments bound to MHC
molecules. T cells recognize antigen when it is presented in this way. - answer✔✔antigen
presentation
The intracellular degradation of foreign proteins into peptides that can bind to MHC molecules
for presentation to T cells. All protein antigens must be processed into peptides before they can
be presented by MHC molecules. - answer✔✔antigen processing
The digestion and breakdown by a cell of its own organelles and proteins in lysosomes. It may be
one route by which cytosolic proteins can be processed for presentation on MHC class II
molecules. - answer✔✔autophagy
A chaperone protein in the endoplasmic reticulum (ER) that binds to partly folded members of
the immunoglobulin superfamily of proteins and retains them in the ER until folding is complete.
- answer✔✔calnexin
A chaperone protein in the endoplasmic reticulum that, together with ERp57 and tapasin, forms
the peptide-loading complex that loads peptides onto newly synthesized MHC class I molecules.
- answer✔✔calreticulin
Small family of MHC class I-like proteins that are not encoded in the MHC and can present
glycolipid antigens to CD4 T cells. - answer✔✔CD1
A peptide of variable length cleaved from the invariant chain (Ii) by proteases. It remains
associated with the MHC class II molecule in an unstable form until it is removed by the HLA-
DM protein. - answer✔✔class II-associated invariant chain peptide (CLIP)
, ©THEBRIGHT EXAM STUDY SOLUTIONS 8/22/2024 12:54 PM
Describes the situation in which the two alleles of a gene are expressed in roughly equal amounts
in the heterozygote. Most genes show this property, including the highly polymorphic MHC
genes. - answer✔✔codominant
The process by which extracellular proteins taken up by dendritic cells can give rise to peptides
presented by MHC class I molecules. It enables antigens from extracellular sources to be
presented by MHC class I molecules and activate CD8 T cells. - answer✔✔cross-presentation
Peptides translated from introns in improperly spliced mRNAs, translations of frameshifts, and
improperly folded proteins, which are recognized and tagged by ubiquitin for rapid degradation
by the proteasome. - answer✔✔defective ribosomal products (DRiP's)
In reference to viral defense mechanisms, the degradation of newly synthesized MHC class I
molecules by viral proteins. - answer✔✔dislocation
The subset of differentiated effector T cells carrying the CD4 co-receptor molecule, which
includes the TH1, TH2, TH17, and regulatory T cells. - answer✔✔effector CD4 T cells
Enzyme in the endoplasmic reticulum that trims polypeptides to a size at which they can bind to
MHC class I molecules. - answer✔✔endoplasmic reticulum aminopeptidase associated with
antigen processing (ERAAP)
Membrane-enclosed intracellular vesicles in which material is carried from and to the cell
exterior. Antigen taken up by phagocytosis generally enters the endosomal system. -
answer✔✔endosomes
A chaperone protein involved in loading peptide onto MHC class I molecules in the endoplasmic
reticulum. - answer✔✔Erp57
A linked set of genes on a chromosome that are typically inherited without undergoing
recombination. The term is used mainly in connection with the linked genes of the major
histocompatibility complex (MHC), which is usually inherited as one haplotype from each
parent. - answer✔✔haplotype
Describes individuals that have two different alleles of a given gene, one inherited from the
mother and one from the father. - answer✔✔heterozygous
The ability of tissues from one individual to be accepted (histocompatible tissues) or rejected
(histoincompatible tissues) if transplanted to another individual. - answer✔✔histocompatibility
Any tissue antigens that provoke an immune response in a genetically nonidentical member of
the same species. The major histocompatibility antigens, also known as MHC molecules, are
encoded in the MHC, and are also the molecules that present foreign peptides to T cells. Minor
histocompatibility antigens comprise other polymorphic proteins that can be recognized as
foreign by an unrelated individual. - answer✔✔histocompatibility antigens (H antigens)
