NSG3022
Pharmacotherapeutics I
COMPLETE MIDTERM GUIDE
© SU 2024/2025
,1. Which of the following factors most significantly affects the
pharmacokinetics of a drug in a patient with liver disease?
a) Age
b) Route of Administration
c) Protein Binding
d) Drug Half-Life
Answer: c) Protein Binding
Rationale: Liver disease affects albumin levels, which impact
drug distribution and binding.
2. A patient on warfarin therapy has a prothrombin time that is
significantly prolonged. What is the most appropriate action by the
nurse?
a) Administer vitamin K
b) Increase the dosage of warfarin
c) Discontinue warfarin indefinitely
d) Monitor the patient for signs of bleeding
Answer: a) Administer vitamin K
Rationale: Vitamin K is the antidote for warfarin toxicity and is
necessary to reverse anticoagulation.
© SU 2024/2025
, 3. Which class of drugs is considered first-line therapy for
managing hypertension in patients with diabetes?
a) Beta-blockers
b) ACE inhibitors
c) Calcium channel blockers
d) Thiazide diuretics
Answer: b) ACE inhibitors
Rationale: ACE inhibitors are protective for renal function in
diabetic patients and are often first-line.
### Fill-in-the-Blank Questions
4. The therapeutic range refers to the concentration of a drug in
the bloodstream that is effective without causing ________.
Answer: toxicity
Rationale: The therapeutic range is the interval between the
minimum effective concentration and the minimum toxic
concentration.
5. The process by which the body eliminates a drug, primarily
through the liver and kidneys, is known as ________.
Answer: excretion
© SU 2024/2025
Pharmacotherapeutics I
COMPLETE MIDTERM GUIDE
© SU 2024/2025
,1. Which of the following factors most significantly affects the
pharmacokinetics of a drug in a patient with liver disease?
a) Age
b) Route of Administration
c) Protein Binding
d) Drug Half-Life
Answer: c) Protein Binding
Rationale: Liver disease affects albumin levels, which impact
drug distribution and binding.
2. A patient on warfarin therapy has a prothrombin time that is
significantly prolonged. What is the most appropriate action by the
nurse?
a) Administer vitamin K
b) Increase the dosage of warfarin
c) Discontinue warfarin indefinitely
d) Monitor the patient for signs of bleeding
Answer: a) Administer vitamin K
Rationale: Vitamin K is the antidote for warfarin toxicity and is
necessary to reverse anticoagulation.
© SU 2024/2025
, 3. Which class of drugs is considered first-line therapy for
managing hypertension in patients with diabetes?
a) Beta-blockers
b) ACE inhibitors
c) Calcium channel blockers
d) Thiazide diuretics
Answer: b) ACE inhibitors
Rationale: ACE inhibitors are protective for renal function in
diabetic patients and are often first-line.
### Fill-in-the-Blank Questions
4. The therapeutic range refers to the concentration of a drug in
the bloodstream that is effective without causing ________.
Answer: toxicity
Rationale: The therapeutic range is the interval between the
minimum effective concentration and the minimum toxic
concentration.
5. The process by which the body eliminates a drug, primarily
through the liver and kidneys, is known as ________.
Answer: excretion
© SU 2024/2025
