Summary Table of Contents for Advanced Genetics (accompanying the purchased course text)

2023




Molecular Genetics
MASTER BIOSCIENCE ENGINEERING: CELLULAR AND GENETIC
KIRSTEN VAN GILS




Kirsten Van Gils (2023-2024)

, PART 1: GENETIC VARIATION
CHAPTER 1: STRUCTURE, ORGANIZATION AND REPLICATION OF GENOMES

PART A: EUKARYOTIC GENOMES

1. Structure and replication of the chromosome
1.1. Centromere, telomere, replication
1.2. Three-dimensional structure of the chromosome: packaging of DNA
1.3. Regulation of chromatin structure
1.4. Nucleosome assembly
2. Genes and repetitive sequences in chromosomes

PARTB: BACTERIAL GENOMES

1. replication , cell division and coordination
1.1. replication
1.2. Cell division
1.3. Coordination
1.4. Timing of initiation of chromosome replication
1.5. Comparison organization and regulation of DNA replication –segregation conflict replication/transcription of
chromosomes in eukaryotes and bacteria
2. structure, physical properties
2.1. structure
2.2. Physical properties



CHAPTER 2: GENE MUTATION AND REPAIR

INTRODUCTION: GENE MUTATION


REPLICATION ERRORS AND REPAIR OF REPLICATION ERROS

1. Replication errors
2. repair of replication errors

DNA DAMAGE

1. hydrolysis
2. alkylation, oxidation and radiation
3. base analogues and intercalating agents

REPAIR AND TOLERANCE OF DNA DAMAGE

1. direct repair of DNA damage
2. base excision repair
3. nucleotide excision repair
4. repair of double-stranded breaks
5. translesion DNA synthesis
6. suppression of mutations




Kirsten Van Gils (2023-2024)