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Sedatives & Hypnotics

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Unlock a thorough understanding of sedatives and hypnotics with these meticulously crafted study notes. Perfect for medical students, healthcare professionals, and pharmacology enthusiasts, these notes provide a detailed and organized approach to these critical drug classes. Key Features: 1. Detailed Overview: • Definitions and Classifications: Understand the basic principles and differences between sedatives and hypnotics. • Mechanism of Action: Insightful explanations of how these drugs interact with the central nervous system to produce their effects. 2. Drug Profiles: • Major Sedatives: Includes Benzodiazepines (e.g., Diazepam, Lorazepam), Non-benzodiazepine sleep aids (e.g., Zolpidem), and Barbiturates. • Major Hypnotics: Detailed notes on both older and newer hypnotics, including their uses, dosages, and side effects. 3. Clinical Applications: • Indications and Contraindications: Clear guidelines on when and why to use these medications, including patient profiles that benefit from these drugs. • Treatment Protocols: Best practices for prescribing and managing therapy, including monitoring and adjusting dosages. 4. Side Effects and Drug Interactions: • Common and Severe Reactions: Comprehensive lists of potential adverse effects and how to recognize and manage them. These notes are designed to provide a robust resource for mastering the subject of sedatives and hypnotics. With a focus on clarity, accuracy, and practical application, they are an invaluable tool for anyone looking to deepen their knowledge in this area. Get your comprehensive notes on sedatives and hypnotics today!

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222
-




22z
SEDATIVES@ HYPNOTICS 2z
-




-d 2
-


-
-
-




↓ excitement & calms
person produces sleep-resembling normal sleep
-0 1
Sleep DNREM :
, ,
2
,
3
,
4
T
Slow-wave sleep
2) REM - 30 %
of sleep


LASSIFICATION :

1 .

BENZODIAZEPINES :
(BLDS)
·

Long-Acting -
Diazepam Chlordiazepam
, ,



Clonazepam Flurazepam ,




Short-actinge Temazepam Lorazepam
,
·

,


Oxazepam Nitrazepam ,




Ultra Short Triazolam Midazolam
Acting -
·
,




2 .
BARBITURATES :




·

Long Acting >
- Phenobarbitone

Short Pentobarbitone
·

Acting >
-




·
Ultrashort
Acting >
-
Thiopentone ,
Methohexitone

, . NON-BENZODIAZEPINES/2-DRUGS
3 :




-
zolpidem zopiclone zaleplon Eszopiclone
, , ,




.
4 OTHERS :

>
-
Melatonin Ramelteon Suvovexant
, ,




·
BENZODIAZEPINES :
CnoGABA-mimeric activity
OF ACTION :
MECHANISM

BLDS from GABA

-diff
.


receptor
↓ BLD
binding
site
Bind to specific site on GABAA-B2D receptor GABA


Enhance

affinity of GABA for its
(GABA facilitatory effect)
receptor

↑ frequency of Cl channel
opening

↑ CL conductance


numonal memb)
Hyperpolarization (f

CNS Depression

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