-
22z
SEDATIVES@ HYPNOTICS 2z
-
-d 2
-
-
-
-
↓ excitement & calms
person produces sleep-resembling normal sleep
-0 1
Sleep DNREM :
, ,
2
,
3
,
4
T
Slow-wave sleep
2) REM - 30 %
of sleep
LASSIFICATION :
1 .
BENZODIAZEPINES :
(BLDS)
·
Long-Acting -
Diazepam Chlordiazepam
, ,
Clonazepam Flurazepam ,
Short-actinge Temazepam Lorazepam
,
·
,
Oxazepam Nitrazepam ,
Ultra Short Triazolam Midazolam
Acting -
·
,
2 .
BARBITURATES :
·
Long Acting >
- Phenobarbitone
Short Pentobarbitone
·
Acting >
-
·
Ultrashort
Acting >
-
Thiopentone ,
Methohexitone
, . NON-BENZODIAZEPINES/2-DRUGS
3 :
-
zolpidem zopiclone zaleplon Eszopiclone
, , ,
.
4 OTHERS :
>
-
Melatonin Ramelteon Suvovexant
, ,
·
BENZODIAZEPINES :
CnoGABA-mimeric activity
OF ACTION :
MECHANISM
BLDS from GABA
-diff
.
receptor
↓ BLD
binding
site
Bind to specific site on GABAA-B2D receptor GABA
↑
Enhance
↓
affinity of GABA for its
(GABA facilitatory effect)
receptor
↓
↑ frequency of Cl channel
opening
↓
↑ CL conductance
↓
numonal memb)
Hyperpolarization (f
↓
CNS Depression