the reactionisspontaneous it will occur nomatterhow activesite is a partofenzymesurface inwhichsubstrate binds
long it takes lockandkeymodel inducedfitmodel
DG givesfreeenergy energyoftheproduct reactant n theactivesite isridgid n activesiteisflexible
energyoftheproduct shouldbeless or equal tothe theactivesitecanchange
complimentarytothesubstra
equilibriumin reaction therate oftheforward reaction fitthesubstrate
t
the rate ofthebackwardreaction cofactors inorganicmolecules ex Most 2n
product
example A B keg By mm coenzymes complexorganicmolecules ex NaDt FADt
g g acid protondonor baseprotonacceptor
1 2 8 21 4 I ve Spon propertiesthatmaketransitionmetal playrow in catalysts
2 9 1
I 0.6 LI tve non spon transitionmetalionshave ahighconcentration ofpositive
charge
3 5 5 1 1 0 Because it can act as a lewisacidanacceptlonepairofe
I
n if so is ve the reaction is spontaneous caninteractwithtwo or moreligands
if sa is the the reaction is non spon helporientthesubstrate withintheactivesite
if keg is more than 1 then the reaction zero ordertherateofreactionisnotallected by adding
is spontaneous ve anysubstrates at vhighsubstrateconc
if keg is less than 1 then the reaction
is non spontaneous the concentration of the reactant Creactiont substratet
increase negativity will increase keg Secondorder therateofreactionwillincreaseto double
energy of the product is less than the whenincreasethe conc of reactant multi
subunits mutibind
my
holoproteins protein t prosthetic K RaleconstantforES formation
apoprotein protein prosthetic k RateconstantforEs dissociation
optimaltemp 370 Ka Rateconstantforproductformation
firstorder reactionthatdepends on 1 substrate n k is small 3 negligable compared to k
long it takes lockandkeymodel inducedfitmodel
DG givesfreeenergy energyoftheproduct reactant n theactivesite isridgid n activesiteisflexible
energyoftheproduct shouldbeless or equal tothe theactivesitecanchange
complimentarytothesubstra
equilibriumin reaction therate oftheforward reaction fitthesubstrate
t
the rate ofthebackwardreaction cofactors inorganicmolecules ex Most 2n
product
example A B keg By mm coenzymes complexorganicmolecules ex NaDt FADt
g g acid protondonor baseprotonacceptor
1 2 8 21 4 I ve Spon propertiesthatmaketransitionmetal playrow in catalysts
2 9 1
I 0.6 LI tve non spon transitionmetalionshave ahighconcentration ofpositive
charge
3 5 5 1 1 0 Because it can act as a lewisacidanacceptlonepairofe
I
n if so is ve the reaction is spontaneous caninteractwithtwo or moreligands
if sa is the the reaction is non spon helporientthesubstrate withintheactivesite
if keg is more than 1 then the reaction zero ordertherateofreactionisnotallected by adding
is spontaneous ve anysubstrates at vhighsubstrateconc
if keg is less than 1 then the reaction
is non spontaneous the concentration of the reactant Creactiont substratet
increase negativity will increase keg Secondorder therateofreactionwillincreaseto double
energy of the product is less than the whenincreasethe conc of reactant multi
subunits mutibind
my
holoproteins protein t prosthetic K RaleconstantforES formation
apoprotein protein prosthetic k RateconstantforEs dissociation
optimaltemp 370 Ka Rateconstantforproductformation
firstorder reactionthatdepends on 1 substrate n k is small 3 negligable compared to k
