Introduction to necrosis and it’s types. Includes associated diseases to
necrosis and examples of case studies related to general pathology.
a. Define necrosis and its significance in pathological processes.
Pathology is the medical speciality that concerns the cause and nature of disease.
Necrosis is related to pathological diagnosis in many ways. Necrosis is an
irreversible cell injury that eventually leads to cell death which results in the
swelling of cellular organelles, rupture of plasma membrane and the eventual lysis
of cell.
Necrosis aids in disease diagnosis and help to maintain haemostasis. They help in
cell repairing and also helpful in inflammatory autoimmune diseases.
“Necrosis does not appear to be associated with caspase activation and appears to
result in cell death in response to injury or pathology (Khalid, 2023).”
b. Explain the key differences between necrosis and apoptosis.
Necrosis is a type of premature cell death processed by membrane disruption, cell
swelling and rupture that leads inflammation. Apoptosis is a cell death which is
usually triggered by normal, healthy processes of the body. Virchow described
necrosis as an ‘unregulated’ form of cell death based on its morphological and
functional characteristics. Whereas, apoptosis is a ‘programmed’ cell death
regulated by a number of genes.
“The harm from necrosis could spread beyond the initial location by affecting
contagious cell groups. While apoptosis is confined and kills only individual or
single cells (Sciences 2023)”. Organelles swell and degrade during necrotic cell
death and lose their functionality. But in the process of apoptosis even after a cell
dies, organelles can continue to function.
necrosis and examples of case studies related to general pathology.
a. Define necrosis and its significance in pathological processes.
Pathology is the medical speciality that concerns the cause and nature of disease.
Necrosis is related to pathological diagnosis in many ways. Necrosis is an
irreversible cell injury that eventually leads to cell death which results in the
swelling of cellular organelles, rupture of plasma membrane and the eventual lysis
of cell.
Necrosis aids in disease diagnosis and help to maintain haemostasis. They help in
cell repairing and also helpful in inflammatory autoimmune diseases.
“Necrosis does not appear to be associated with caspase activation and appears to
result in cell death in response to injury or pathology (Khalid, 2023).”
b. Explain the key differences between necrosis and apoptosis.
Necrosis is a type of premature cell death processed by membrane disruption, cell
swelling and rupture that leads inflammation. Apoptosis is a cell death which is
usually triggered by normal, healthy processes of the body. Virchow described
necrosis as an ‘unregulated’ form of cell death based on its morphological and
functional characteristics. Whereas, apoptosis is a ‘programmed’ cell death
regulated by a number of genes.
“The harm from necrosis could spread beyond the initial location by affecting
contagious cell groups. While apoptosis is confined and kills only individual or
single cells (Sciences 2023)”. Organelles swell and degrade during necrotic cell
death and lose their functionality. But in the process of apoptosis even after a cell
dies, organelles can continue to function.
