Immune
-
Chronic ITP
Unrombocytopeni
-
perpara
-encronic
Definition
*
ITP is caused
by autoantibody-mediated
:
destruction
of platelets
.
* Causes : -
() 10/idiopathic G
(ii) Variety of predisposing cond" &
exposures
=
2
↳ individuals with
systemic lupus erythematous
· HIV
infection
Brell
·
.
Lymphoma
*
Pathogenesis :
Autoantibodies
↓
most
often directed
against platelet
memb .
glycoproteins III-IIa or Ib-I
demonstrated
minein
I
1
Plasmo
bound to platelet
&
↓ autoab
d
also bind
surface
80 %
patients As in
autoimmune hemolytic anemias may
=
to &
Antiplatelet ab antiplatelet ob acts opsonins as ↓
of IgG class
are
↓
"damage megakaryotes
recognized by IgG E receptors ↓
&
↓ in
platelet production
expressed on
phagocytes ↓
↓
exacerbate the
Ted
further
platelet destruction
thrombocytopension.
-
*
Morphology
: -
splen
-
-
·
Principle changes of thrombocytopener purpura are
found in I -
bone marrow
blood .
2
changes found anywhere
in
.
body
·
Spleen normal
size
·
a
sinusoid associated with
= often
·
enlargement of the splenic follicles prominent ractive garminal
res
-
Chronic ITP
Unrombocytopeni
-
perpara
-encronic
Definition
*
ITP is caused
by autoantibody-mediated
:
destruction
of platelets
.
* Causes : -
() 10/idiopathic G
(ii) Variety of predisposing cond" &
exposures
=
2
↳ individuals with
systemic lupus erythematous
· HIV
infection
Brell
·
.
Lymphoma
*
Pathogenesis :
Autoantibodies
↓
most
often directed
against platelet
memb .
glycoproteins III-IIa or Ib-I
demonstrated
minein
I
1
Plasmo
bound to platelet
&
↓ autoab
d
also bind
surface
80 %
patients As in
autoimmune hemolytic anemias may
=
to &
Antiplatelet ab antiplatelet ob acts opsonins as ↓
of IgG class
are
↓
"damage megakaryotes
recognized by IgG E receptors ↓
&
↓ in
platelet production
expressed on
phagocytes ↓
↓
exacerbate the
Ted
further
platelet destruction
thrombocytopension.
-
*
Morphology
: -
splen
-
-
·
Principle changes of thrombocytopener purpura are
found in I -
bone marrow
blood .
2
changes found anywhere
in
.
body
·
Spleen normal
size
·
a
sinusoid associated with
= often
·
enlargement of the splenic follicles prominent ractive garminal
res
