CLINICAL CORRELATES UNIT 15
QUESTIONS WITH COMPLETE
ANSWERS { GRADED A+}
Maraviroc - ✔✔Entry inhibitor. HIV antiviral that works as a
chemokine coreceptor antagonist. Binds specifically to CCR5 to prevent
its interaction with gp120. This drug is limited only to patients with R5
tropic HIV.
Enfuvirtide - ✔✔Entry inhibitor. HIV antiviral that works as a fusion
inhibitor (FI). Binds to gp41 to prevent conformational change required
for fusion to occur.
Fostemsavir - ✔✔Entry inhibitor. HIV antiviral that acts as a gp120
attachment inhibitor, preventing its interaction with CD4.
,Ibalizumab - ✔✔Entry inhibitor. HIV antiviral that works as a CD4
Post Attachment Inhibitor, inducing steric hindrance and preventing the
conformational change that is required for HIV fusion and entry. Doesn't
affect the binding of CD4 to gp120.
Azidothymidine (AZT) - ✔✔Reverse transcriptase inhibitor. HIV
antiviral categorized as a nucleoside inhibitor (NRTI). Works by being
incorporated into growing DNA chain during provirus synthesis, causing
chain termination.
Nevirapine - ✔✔Reverse transcriptase inhibitor. HIV antiviral
categorized as a nonnucleoside inhibitor (NNRT). Works by binding to
reverse transcriptase and inhibiting its activity.
Raltegravir - ✔✔Integrase inhibitor (II). HIV antiviral that blocks the
integration of the viral DNA genome into the host's cellular genome.
Most commonly used.
, Saquinavir - ✔✔Protease inhibitor (PI). HIV antiviral that functions as
a peptidomimetic inhibitor of the viral protease, leading to the
production of immature/defective HIV particles.
Acyclovir - ✔✔HSV antiviral that works as a nucleoside analogue.
Utilizes viral thymidine kinase to ultimately inhibit viral DNA
polymerase, preventing HSV genome replication.
Foscarnet - ✔✔HSV antiviral that works as a non-nucleoside inhibitor
in acyclovir (tk-) resistant HSV. Targets and inhibits the viral DNA
polymerase, preventing HSV genome replication.
HPV Vaccine - ✔✔Vaccine composed of an L1 capsid protein that self-
assembles into a virus-like particle (VLP) to confer immunity to an
individual.
Gonococcal Ophthalmia Neonatorum - ✔✔Condition caused by the
vertical transmission of Neisseria gonorrhoeae to a neonate during
childbirth. Symptoms arise 2-5 days post delivery and begin with
nonspecific conjunctivitis before progressing to tense edema of the
QUESTIONS WITH COMPLETE
ANSWERS { GRADED A+}
Maraviroc - ✔✔Entry inhibitor. HIV antiviral that works as a
chemokine coreceptor antagonist. Binds specifically to CCR5 to prevent
its interaction with gp120. This drug is limited only to patients with R5
tropic HIV.
Enfuvirtide - ✔✔Entry inhibitor. HIV antiviral that works as a fusion
inhibitor (FI). Binds to gp41 to prevent conformational change required
for fusion to occur.
Fostemsavir - ✔✔Entry inhibitor. HIV antiviral that acts as a gp120
attachment inhibitor, preventing its interaction with CD4.
,Ibalizumab - ✔✔Entry inhibitor. HIV antiviral that works as a CD4
Post Attachment Inhibitor, inducing steric hindrance and preventing the
conformational change that is required for HIV fusion and entry. Doesn't
affect the binding of CD4 to gp120.
Azidothymidine (AZT) - ✔✔Reverse transcriptase inhibitor. HIV
antiviral categorized as a nucleoside inhibitor (NRTI). Works by being
incorporated into growing DNA chain during provirus synthesis, causing
chain termination.
Nevirapine - ✔✔Reverse transcriptase inhibitor. HIV antiviral
categorized as a nonnucleoside inhibitor (NNRT). Works by binding to
reverse transcriptase and inhibiting its activity.
Raltegravir - ✔✔Integrase inhibitor (II). HIV antiviral that blocks the
integration of the viral DNA genome into the host's cellular genome.
Most commonly used.
, Saquinavir - ✔✔Protease inhibitor (PI). HIV antiviral that functions as
a peptidomimetic inhibitor of the viral protease, leading to the
production of immature/defective HIV particles.
Acyclovir - ✔✔HSV antiviral that works as a nucleoside analogue.
Utilizes viral thymidine kinase to ultimately inhibit viral DNA
polymerase, preventing HSV genome replication.
Foscarnet - ✔✔HSV antiviral that works as a non-nucleoside inhibitor
in acyclovir (tk-) resistant HSV. Targets and inhibits the viral DNA
polymerase, preventing HSV genome replication.
HPV Vaccine - ✔✔Vaccine composed of an L1 capsid protein that self-
assembles into a virus-like particle (VLP) to confer immunity to an
individual.
Gonococcal Ophthalmia Neonatorum - ✔✔Condition caused by the
vertical transmission of Neisseria gonorrhoeae to a neonate during
childbirth. Symptoms arise 2-5 days post delivery and begin with
nonspecific conjunctivitis before progressing to tense edema of the
