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Summary Vibrio cholerae

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Vibrio cholerae is a highly motile, comma-shaped, gram-negative bacteria that causes the deadly diarrheal disease cholera. It was first described in 1849 and isolated in 1884. The bacterium is primarily found in contaminated water and food, often associated with poor sanitation systems. Its pathogenicity stems from its ability to produce cholerae toxin, leading to severe dehydration and diarrhea. Understanding the entire life cycle of Vibrio cholerae is crucial for combating infectious diseases. Its virulence is influenced by adhesion molecules and toxins that disrupt normal cellular function.

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Vibrio cholerae


Introduction: Vibrio cholerae is a highly motile, comma shaped, gram-negative
bacteria with a single, polar flagellum for movement. The active movement of
vibrio cholerae inspired the genus name because “vibrio” in Latin means “to
quiver”. V. cholerae was first described by Felix -Archimede Pouchet in 1849 as
some kind of protozoa. Filippo Pacini correctly identified it as a bacterium in Italy
in 1854. V. cholerae was first isolated in pure culture by Robert Koch in 1884.
Italians at that time believed that diseases like cholera came from "bad air" or the
Greek term “miasma." John Snow, a doctor known as the father of epidemiology,
did a study during the London cholera epidemic of 1854 from which he concluded
that cholera was not passed by bad air but by contaminated water, and discovered
that a well that provided water to the public was collecting the leaching’s of a
bacteria laden cesspit. Snow had the handle removed from a water pump that was
found to be the neighborhood's source of the contaminated water, and immediately
the epidemic began to subside.
Scientific Classification:
Domain: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio cholerae
Morphology and Characteristics of Vibrio Cholerae

∙ Gram- negative rods
∙ Curved and comma shaped
∙ Highly motile; single polar flagella

, ∙ Sheathed, polar flagellum
∙ Non-spore forming
∙ Associated with salt water
∙ Oxidase positive
∙ Facultative anaerobe
∙ 1.4-2.6µm length and .5-.8 µm width
∙ Tolerate alkaline conditions to pH 9
∙ Produces cholera toxin




Figure: Vibrio Cholerae


Structural Characteristics of Vibrio cholerae

∙ Cell Wall
∙ Cell Membrane
∙ Cytoplasm
∙ Flagellum
∙ Ribosomes
∙ DNA




Figure: Vibrio cholerae

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