Handbook for Clinical
Management of Dengue
,WHO Library Cataloguing-in-Publication Data
Handbook for clinical management of dengue.
1.Dengue – therapy. 2.Dengue – diagnosis. 3.Clinical medicine. 4.Handbooks. I.World
Health Organization.
ISBN 978 92 4 150471 3 (NLM classification: WC 528)
© World Health Organization 2012
All rights reserved.
Publications of the World Health Organization are available on the WHO web site (www.
who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue
Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail:
).
Requests for permission to reproduce or translate WHO publications – whether for sale or
for noncommercial distribution – should be addressed to WHO Press through the WHO
web site (http://www.who.int/about/licensing/copyright_form/en/index.html).
The designations employed and the presentation of the material in this publication do
not imply the expression of any opinion whatsoever on the part of the World Health
Organization concerning the legal status of any country, territory, city or area or of its
authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on
maps represent approximate border lines for which there may not yet be full agreement.
The mention of specific companies or of certain manufacturers’ products does not imply
that they are endorsed or recommended by the World Health Organization in preference
to others of a similar nature that are not mentioned. Errors and omissions excepted, the
names of proprietary products are distinguished by initial capital letters.
All reasonable precautions have been taken by the World Health Organization to verify
the information contained in this publication. However, the published material is being
distributed without warranty of any kind, either expressed or implied. The responsibility
for the interpretation and use of the material lies with the reader. In no event shall the
World Health Organization be liable for damages arising from its use.
Cover photographs were provided by Dr Thomas Scott and Dr Raman Velayudhan.
,Handbook for clinical management
of dengue
, Contents
Foreword .............................................................................................................................. v
Methodology........................................................................................................................ vi
Acknowledgements ............................................................................................................. vi
Abbreviations ...................................................................................................................... vii
1.
Overview, differential diagnosis and dengue diagnostics ............................................. 1
1.1
Overview and course of dengue illness ................................................................. 1
1.1.1
Febrile phase .................................................................................................. 2
1.1.2
Critical phase .................................................................................................. 2
1.1.3
Recovery phase.............................................................................................. 3
1.1.4
Severe dengue ............................................................................................... 4
1.1.5
References ..................................................................................................... 6
1.2
Dengue case classification .................................................................................... 7
1.2.1
Development of the revised dengue case classification ................................. 7
1.2.2
References ..................................................................................................... 9
1.2.3 Differential diagnoses of dengue ....................................................................... 10
1.2.4 References......................................................................................................... 13
1.3
Dengue diagnostics for clinicians ........................................................................ 15
1.3.1
References ................................................................................................... 20
2.
Recommendations for clinical management ............................................................... 22
2.1
A stepwise approach to the management of dengue .......................................... 22
2.1.1
Step I – Overall assessment......................................................................... 22
2.1.2
Step II – Diagnosis, assessment of disease phase and severity ................. 23
2.1.3
Step III – Disease notification and management decision (Groups A–C) .... 23
2.2
Treatment according to Groups A–C (1).............................................................. 25
2.2.1
Group A ........................................................................................................ 25
2.2.2
Group B ........................................................................................................ 26
2.2.3
Group C ........................................................................................................ 27
2.2.4
References ................................................................................................... 38
2.3
Complications and intensive care management .................................................. 39
2.3.1
Acute respiratory distress and failure ........................................................... 43
ii
Management of Dengue
,WHO Library Cataloguing-in-Publication Data
Handbook for clinical management of dengue.
1.Dengue – therapy. 2.Dengue – diagnosis. 3.Clinical medicine. 4.Handbooks. I.World
Health Organization.
ISBN 978 92 4 150471 3 (NLM classification: WC 528)
© World Health Organization 2012
All rights reserved.
Publications of the World Health Organization are available on the WHO web site (www.
who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue
Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail:
).
Requests for permission to reproduce or translate WHO publications – whether for sale or
for noncommercial distribution – should be addressed to WHO Press through the WHO
web site (http://www.who.int/about/licensing/copyright_form/en/index.html).
The designations employed and the presentation of the material in this publication do
not imply the expression of any opinion whatsoever on the part of the World Health
Organization concerning the legal status of any country, territory, city or area or of its
authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on
maps represent approximate border lines for which there may not yet be full agreement.
The mention of specific companies or of certain manufacturers’ products does not imply
that they are endorsed or recommended by the World Health Organization in preference
to others of a similar nature that are not mentioned. Errors and omissions excepted, the
names of proprietary products are distinguished by initial capital letters.
All reasonable precautions have been taken by the World Health Organization to verify
the information contained in this publication. However, the published material is being
distributed without warranty of any kind, either expressed or implied. The responsibility
for the interpretation and use of the material lies with the reader. In no event shall the
World Health Organization be liable for damages arising from its use.
Cover photographs were provided by Dr Thomas Scott and Dr Raman Velayudhan.
,Handbook for clinical management
of dengue
, Contents
Foreword .............................................................................................................................. v
Methodology........................................................................................................................ vi
Acknowledgements ............................................................................................................. vi
Abbreviations ...................................................................................................................... vii
1.
Overview, differential diagnosis and dengue diagnostics ............................................. 1
1.1
Overview and course of dengue illness ................................................................. 1
1.1.1
Febrile phase .................................................................................................. 2
1.1.2
Critical phase .................................................................................................. 2
1.1.3
Recovery phase.............................................................................................. 3
1.1.4
Severe dengue ............................................................................................... 4
1.1.5
References ..................................................................................................... 6
1.2
Dengue case classification .................................................................................... 7
1.2.1
Development of the revised dengue case classification ................................. 7
1.2.2
References ..................................................................................................... 9
1.2.3 Differential diagnoses of dengue ....................................................................... 10
1.2.4 References......................................................................................................... 13
1.3
Dengue diagnostics for clinicians ........................................................................ 15
1.3.1
References ................................................................................................... 20
2.
Recommendations for clinical management ............................................................... 22
2.1
A stepwise approach to the management of dengue .......................................... 22
2.1.1
Step I – Overall assessment......................................................................... 22
2.1.2
Step II – Diagnosis, assessment of disease phase and severity ................. 23
2.1.3
Step III – Disease notification and management decision (Groups A–C) .... 23
2.2
Treatment according to Groups A–C (1).............................................................. 25
2.2.1
Group A ........................................................................................................ 25
2.2.2
Group B ........................................................................................................ 26
2.2.3
Group C ........................................................................................................ 27
2.2.4
References ................................................................................................... 38
2.3
Complications and intensive care management .................................................. 39
2.3.1
Acute respiratory distress and failure ........................................................... 43
ii