NUR 210 EXAM 1 GALEN COLLEGE OF NURSING LATEST
ACTUAL EXAM
4 processes included in pharmacokinetics - ANSWER: Absorption
Distribution
Metabolism
Excretion
Drug ____ is the movement of the drug into the bloodstream after administration -
ANSWER: absorption
Why do we have enteric-coated drugs? - ANSWER: They resist disintegration in the
gastric acid of the stomach, so disintegration does not occur until the drug reaches
the alkaline environment of the small intestine
Where is the primary site of drug absorption? - ANSWER: The small intestine
Where is the primary site for drug metabolism ? - ANSWER: liver
Is when drugs are metabolized by the liver into an inactive form for excretion -
ANSWER: First-pass metabolism
T/F: most PO drugs are affected to some degree by first-pass metabolism - ANSWER:
True
The percentage of administered drug available for activity - ANSWER: bioavailability
5 factors that alter bioavailability - ANSWER: Drug form
Route
Gastric mucosa and motility
Administration with food and other drugs
Changes in liver metabolism
Is the movement of the drug from circulation to body tissue - ANSWER: Distribution
Drug distribution is influenced by the ability of the drug to bind to ____ and ____ -
ANSWER: Tissue and plasma proteins
The portion of the drug that is unbound to the plasma proteins is called - ANSWER:
Free drug
4 functions of NSAIDS - ANSWER: Antipyretic
Antiplatelet
Antiinflammatory
Analgesia
, What are the two non-selective NSAIDs - ANSWER: Ibuprofen and aspirin
What are the 3 s/s of potential ASA hypersensitivity and/or OD - ANSWER: Tinnitus
Vertigo
Bronchospasm
COX-1 makes prostaglandins that do what - ANSWER: Protect the stomach and cause
platelet aggregation (clotting)
COX-2 makes prostaglandins that do what - ANSWER: Sensitizes us to pain and
increase inflammation
What is the MOA common to all NSAIDs - ANSWER: They all block COX-2 high helps
with pain and inflammation
What are the 5 G's that can increase bleeding - ANSWER: Ginger
Garlic
Ginseng
Green tea
Ginkgo
What affects the albumin levels - ANSWER: Liver or kidney disease and
malnourishment
Common tests to determine renal function - ANSWER: BUN and creatinine
What is the nonbenzo that treats insomnia - ANSWER: Zolpidem
Depress the CNS, alleviate pain, and causes loss of consciousness - ANSWER: General
anesthesics
Benzodiazepine medication that can induce anesthesia and cause conscious
sedation; should be avoided if the pt has a hx of cardiopulmonary disease - ANSWER:
Midazolam
Two adverse reactions from IV anesthetics - ANSWER: Respiratory depression and
cardiovascular depression
What are the two main SEs of spinal and epidural anesthesia - ANSWER: Hypotension
and headache
Anti gout medication - ANSWER: Allopurinol
MOA of allopurinol - ANSWER: Increases uric acid excretion and decrease its
production
ACTUAL EXAM
4 processes included in pharmacokinetics - ANSWER: Absorption
Distribution
Metabolism
Excretion
Drug ____ is the movement of the drug into the bloodstream after administration -
ANSWER: absorption
Why do we have enteric-coated drugs? - ANSWER: They resist disintegration in the
gastric acid of the stomach, so disintegration does not occur until the drug reaches
the alkaline environment of the small intestine
Where is the primary site of drug absorption? - ANSWER: The small intestine
Where is the primary site for drug metabolism ? - ANSWER: liver
Is when drugs are metabolized by the liver into an inactive form for excretion -
ANSWER: First-pass metabolism
T/F: most PO drugs are affected to some degree by first-pass metabolism - ANSWER:
True
The percentage of administered drug available for activity - ANSWER: bioavailability
5 factors that alter bioavailability - ANSWER: Drug form
Route
Gastric mucosa and motility
Administration with food and other drugs
Changes in liver metabolism
Is the movement of the drug from circulation to body tissue - ANSWER: Distribution
Drug distribution is influenced by the ability of the drug to bind to ____ and ____ -
ANSWER: Tissue and plasma proteins
The portion of the drug that is unbound to the plasma proteins is called - ANSWER:
Free drug
4 functions of NSAIDS - ANSWER: Antipyretic
Antiplatelet
Antiinflammatory
Analgesia
, What are the two non-selective NSAIDs - ANSWER: Ibuprofen and aspirin
What are the 3 s/s of potential ASA hypersensitivity and/or OD - ANSWER: Tinnitus
Vertigo
Bronchospasm
COX-1 makes prostaglandins that do what - ANSWER: Protect the stomach and cause
platelet aggregation (clotting)
COX-2 makes prostaglandins that do what - ANSWER: Sensitizes us to pain and
increase inflammation
What is the MOA common to all NSAIDs - ANSWER: They all block COX-2 high helps
with pain and inflammation
What are the 5 G's that can increase bleeding - ANSWER: Ginger
Garlic
Ginseng
Green tea
Ginkgo
What affects the albumin levels - ANSWER: Liver or kidney disease and
malnourishment
Common tests to determine renal function - ANSWER: BUN and creatinine
What is the nonbenzo that treats insomnia - ANSWER: Zolpidem
Depress the CNS, alleviate pain, and causes loss of consciousness - ANSWER: General
anesthesics
Benzodiazepine medication that can induce anesthesia and cause conscious
sedation; should be avoided if the pt has a hx of cardiopulmonary disease - ANSWER:
Midazolam
Two adverse reactions from IV anesthetics - ANSWER: Respiratory depression and
cardiovascular depression
What are the two main SEs of spinal and epidural anesthesia - ANSWER: Hypotension
and headache
Anti gout medication - ANSWER: Allopurinol
MOA of allopurinol - ANSWER: Increases uric acid excretion and decrease its
production
