MLS HEMATOLOGY EXAM /HEMATOLOGY MLS ACTUAL EXAM
400 QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES
The following are compounds formed in heme synthesis:
coproporphyrinogen, porphobilinogen, uroporphyrinogen, protoporphyrinogen.
What are the correct order in which they are formed? - ANSWER: porpho,
uroporphy, copro, proto
Which of the following is true about megakaryocytes in a bone marrow?
a. an average of 2-10 should be found in LPF.
b. the majority of forms are MK1 stage.
c. morphology must be determined from Bx section.
d. Quant. estimation done using 100x oil immersion. - ANSWER: a. 2-10 found in LPF.
The characteristic erythrocyte found in pernicious anemia is: - ANSWER: macrocytic
Hemolysis in PNH is:
a. temp. dependent
b. complement independent
c. Ab mediated
d. caused by red cell membrane defect - ANSWER: d. caused by rbc membrane
defect
Which of the following is closely associated with idiopathic hemochromatosis?
a. iron overload in tissue
b. target cells
c. basophilic stipp.
d. ringed sideroblasts - ANSWER: a. iron overload in tissue
The DAT test helps distinguish:
a. inherited form acq. spherocytosis.
b. intravascular from extravascular hemolysis
c. hetero from homo thalassemia
d. SC trait from SC disease - ANSWER: a. inherited from acq. spherocytosis
Factors commonly involved in producing anemia in patients with chronic renal
disease:
a. marrow hypoplasia
b. inadequate erythropoiesis
c. B12 def.
d. increased erythropoietin production - ANSWER: b. inadequate erythropoiesis
The hypoproliferative red cell population in the bone marrow of uremic patients is
caused by:
, a. infiltration of BM by toxic waste products
b. decreased levels of erythropoietin
c. defective globin synthesis
d. overcrowding of BM by myeloid precursors. - ANSWER: b. decreased levels of
erythropoietin
Which one of the following hypochromic anemias is usually associated with a normal
free erythrocyte protoporphyrin level?
a. anemia of chronic disease
b. iron def.
c. lead poisoning
d. Thalassemia minor - ANSWER: d. thalassemia minor
A 20 year old African American has peripheral blood changed suggesting thalassemia
minor. The quantitative hemoglobin A2 level is normal but Hgb F level is 5%. (Normal
<2%)
a. alpha thalassemia minor
b. beta thalassemia minor
c. delta beta thalassemia minor
d. hereditary persistence of fetal Hgb - ANSWER: c. delta beta thalassemia
Anemia secondary to uremia characteristically is: - ANSWER:
normocytic/normochromic
To what class disorders does Fanconi anemia belong?
a. hypoproliferative
b. myeloproliferative
c. myelodysplastic
d. mitochondrial - ANSWER: hypoproliferative
2 causes of acquired pure red cell aplasia are:
a. CMV and parvo
b. thymoma and parvo
c. parvo and squamous cell carcinoma
d. squamous cell carcinoma and thymoma - ANSWER: b. thymoma and parvo
What tumor are associated with erythrocytosis due to excessive erythropoietin
production: - ANSWER: renal cell carcinoma
Which of the following statements about Hgb D and G is true.
a. they are abnormal
b. they migrate with Hgb S
c. theyre caused by mutations in beta globin gene.
d. they cannot be separated on citrate gels. - ANSWER: b. they both migrate with
Hgb S.
This hemoglobinopathy results from fusion product of the delta and beta gene:
400 QUESTIONS AND CORRECT DETAILED ANSWERS WITH
RATIONALES
The following are compounds formed in heme synthesis:
coproporphyrinogen, porphobilinogen, uroporphyrinogen, protoporphyrinogen.
What are the correct order in which they are formed? - ANSWER: porpho,
uroporphy, copro, proto
Which of the following is true about megakaryocytes in a bone marrow?
a. an average of 2-10 should be found in LPF.
b. the majority of forms are MK1 stage.
c. morphology must be determined from Bx section.
d. Quant. estimation done using 100x oil immersion. - ANSWER: a. 2-10 found in LPF.
The characteristic erythrocyte found in pernicious anemia is: - ANSWER: macrocytic
Hemolysis in PNH is:
a. temp. dependent
b. complement independent
c. Ab mediated
d. caused by red cell membrane defect - ANSWER: d. caused by rbc membrane
defect
Which of the following is closely associated with idiopathic hemochromatosis?
a. iron overload in tissue
b. target cells
c. basophilic stipp.
d. ringed sideroblasts - ANSWER: a. iron overload in tissue
The DAT test helps distinguish:
a. inherited form acq. spherocytosis.
b. intravascular from extravascular hemolysis
c. hetero from homo thalassemia
d. SC trait from SC disease - ANSWER: a. inherited from acq. spherocytosis
Factors commonly involved in producing anemia in patients with chronic renal
disease:
a. marrow hypoplasia
b. inadequate erythropoiesis
c. B12 def.
d. increased erythropoietin production - ANSWER: b. inadequate erythropoiesis
The hypoproliferative red cell population in the bone marrow of uremic patients is
caused by:
, a. infiltration of BM by toxic waste products
b. decreased levels of erythropoietin
c. defective globin synthesis
d. overcrowding of BM by myeloid precursors. - ANSWER: b. decreased levels of
erythropoietin
Which one of the following hypochromic anemias is usually associated with a normal
free erythrocyte protoporphyrin level?
a. anemia of chronic disease
b. iron def.
c. lead poisoning
d. Thalassemia minor - ANSWER: d. thalassemia minor
A 20 year old African American has peripheral blood changed suggesting thalassemia
minor. The quantitative hemoglobin A2 level is normal but Hgb F level is 5%. (Normal
<2%)
a. alpha thalassemia minor
b. beta thalassemia minor
c. delta beta thalassemia minor
d. hereditary persistence of fetal Hgb - ANSWER: c. delta beta thalassemia
Anemia secondary to uremia characteristically is: - ANSWER:
normocytic/normochromic
To what class disorders does Fanconi anemia belong?
a. hypoproliferative
b. myeloproliferative
c. myelodysplastic
d. mitochondrial - ANSWER: hypoproliferative
2 causes of acquired pure red cell aplasia are:
a. CMV and parvo
b. thymoma and parvo
c. parvo and squamous cell carcinoma
d. squamous cell carcinoma and thymoma - ANSWER: b. thymoma and parvo
What tumor are associated with erythrocytosis due to excessive erythropoietin
production: - ANSWER: renal cell carcinoma
Which of the following statements about Hgb D and G is true.
a. they are abnormal
b. they migrate with Hgb S
c. theyre caused by mutations in beta globin gene.
d. they cannot be separated on citrate gels. - ANSWER: b. they both migrate with
Hgb S.
This hemoglobinopathy results from fusion product of the delta and beta gene:
