Multiple Choice `
Identify the choice that best completes the statement or answers the question.
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1. The major impact ofthe physiological changes that occur with aging is:
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A. Reduced physiological reserve
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B. Reduced homeostatic mechanisms
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C. Impaired immunological response
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D. All of the above
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2. Thestrongest evidence regarding normal physiological aging is
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availablethrough:
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A. Randomized controlled clinicaltrials
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B. Cross-sectional studies
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C. Longitudinal studies
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D. Case control studies
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3. All ofthe following statements aretrue about laboratory values in olderadults
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except:
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A. Reference ranges are preferable
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B. Abnormal findings are often due to physiological aging ` ` ` ` ` ` `
C. Normal ranges may not be applicable for older adults
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D. Reference values are not necessarilyacceptable values
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4. Biochemical individualityis best described as: ` ` ` ` `
A. Each individual’s variation is often much greater than that ofa larger
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group
B. The unique biochemical profile of a selected population
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C. The truly “normal” individual—falling within average range
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D.What the body does to the drug
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, D. The side effects commonly associated with the drug
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7 All the following statements are false about drug absorption except:
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. A. Antacids increase the bioavailability of digitalis ` ` ` ` `
B. Gastric acidity decreases with age ` ` ` `
C. Anticholinergics increase colonic motility ` ` `
D. Underlying chronic disease has little impact on drug absorption ` ` ` ` ` ` ` `
8 All of the following statements are true about drug distribution in the elderlyexcept:
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. A. Drugs distributed in water have lower concentration
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B. Drugs distributed in fat have less intense, more prolonged effect
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C. Drugs highly protein bound have greater potential to cause
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anadverse drugreaction
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D. The fastest way to deliver a drug to the action site is by inhalation
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9 Men have faster and more efficient biotransformation of drugs and this is thoughtto
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. ` bedue to:
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A. Less obesity rates than women ` ` ` `
B. Prostate enlargement `
C. Testosterone
D. Less estrogen than women ` ` `
10 The cytochrome p system involves enzymes that are generally:
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. A. Inhibited by drugs ` `
B. Induced by drugs ` `
C. Inhibited or induced by drugs ` ` ` `
D. Associated with decreased liver perfusion ` ` ` `
11 A statement not shown to be true about pharmacodynamics changes with agingis:
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. A. Decreased sensitivity to oral anticoagulants ` ` ` `
B. Enhanced sensitivity to central nervous system drugs ` ` ` ` ` `
C. Drug responsiveness can be influenced by patient activity level
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D. There is a decreased sensitivity to beta blockers
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12 Atypical presentation of disease in the elderly is reflected by all the followingexcept:
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. A. Infection without fever ` `
B. Depression without dysphoric mood ` ` `
C. Myocardial infarction with chest pain and diaphoresis ` ` ` ` ` `
D. Cardiac manifestations of thyroid disease ` ` ` `
, 13 Functional abilities are best assessed by:
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. A. Self-report of function
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B. Observed assessment of function
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C. A comprehensive head-to-toe examination
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D. Family report of function
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