Stereochemistry Exam 2024/2025 fully
solved & updated
stereocenter (chiral center) - ANSWER-Tetrahedral atom (usually carbon) with
four different substituent groups
Optical activity - ANSWER-The degree to which a substance rotates the plane of
polarized light
A physical property used to characterize chiral substances
Relative configuration - ANSWER-Compares the arrangement of atoms in space
to some reference
chiral - ANSWER-Molecule that cannot be superimposed on its own mirror image
(asymmetric— any molecule that has a plane of symmetry cannot be chiral.)
Cahn-Ingold-Prelog system to define stereochemical configuration - ANSWER-1.
assign a priority to each of the four substituents bound to the chiral atom
(Lowest priority facing back)
2. trace a circle defined by the #1, #2, and #3 priority groups, in increasing order.
3. Assign R/S accordingly
racemic mixture - ANSWER-50:50 mixture of both the R and the S enantiomer.
Optically inactive.
A 'squiggly' bond in a chemical structure indicates
Proteins as chiral molecules - ANSWER-very sensitive to stereochemistry
Certain configurations will not bind as well as others
'S' (from the Latin sinister) - ANSWER-(left-handed)
Counterclockwise
solved & updated
stereocenter (chiral center) - ANSWER-Tetrahedral atom (usually carbon) with
four different substituent groups
Optical activity - ANSWER-The degree to which a substance rotates the plane of
polarized light
A physical property used to characterize chiral substances
Relative configuration - ANSWER-Compares the arrangement of atoms in space
to some reference
chiral - ANSWER-Molecule that cannot be superimposed on its own mirror image
(asymmetric— any molecule that has a plane of symmetry cannot be chiral.)
Cahn-Ingold-Prelog system to define stereochemical configuration - ANSWER-1.
assign a priority to each of the four substituents bound to the chiral atom
(Lowest priority facing back)
2. trace a circle defined by the #1, #2, and #3 priority groups, in increasing order.
3. Assign R/S accordingly
racemic mixture - ANSWER-50:50 mixture of both the R and the S enantiomer.
Optically inactive.
A 'squiggly' bond in a chemical structure indicates
Proteins as chiral molecules - ANSWER-very sensitive to stereochemistry
Certain configurations will not bind as well as others
'S' (from the Latin sinister) - ANSWER-(left-handed)
Counterclockwise
