Pharmacodynamics and Pharmacokinetics
Practise Questions And answers
1. What is pharmacology: The study of drugs and their interaction with biological systems
2. What is included in the field of pharmacology: Fundamental principles gov- erning drug action
Therapeutic application of drugs in patients
Adverse effects, toxicities, and drug interactions associated with drug usage in patients
3. What is a drug: A chemical or biochemical that interacts with a living system to induce a physiological response
Most often drugs interact with natural macromolecules called receptors to produce these effects
4. Traditionally most drugs have been . However many newer drugs are, which
have a much larger structure.: small organic molecules; antibodies
5. What is a receptor: • A natural macromolecule which binds a drug to initiate the drug's effect.
•Most are proteins, but can sometimes be other macromolecules (e.g. large carbo- hydrates, etc.).
• A small number of drugs, including antiseptics and antacids produce their effects without specific receptor
interactions.
6. What are the broad receptor superfamilies: Ion channels G protein coupled
receptors
Tyrosine kinase receptors Steroid
hormone receptors
7. What are ion channels as drug receptors: Typically are cell membrane proteins that contain a pore, and when open
allows ions to move in or out of the cell
Drugs can bind to these receptors and either open or close the channel
8. Examples of drugs that interact with ion channels: Local anesthetics
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, Pharmacodynamics and Pharmacokinetics
Practise Questions And answers
9. What are G protein coupled receptors as drug receptors: Typically cell mem- brane proteins with seven
transmembrane segments
Indirectly activate or inhibit various enzymes using a member of the g-protein family as intermediaries
10.Examples of drugs that interact with G-protein coupled receptors: Vaso- constrictors
11.What are tyrosine kinases as drug receptors: Typically cell membrane pro- teins with a transmembrane
segment
Activation by drugs often leads to receptor dimerization and phosphorylation, fol- lowed by a receptor binding to various
signaling proteins to mediate a physiological effect
2/
Practise Questions And answers
1. What is pharmacology: The study of drugs and their interaction with biological systems
2. What is included in the field of pharmacology: Fundamental principles gov- erning drug action
Therapeutic application of drugs in patients
Adverse effects, toxicities, and drug interactions associated with drug usage in patients
3. What is a drug: A chemical or biochemical that interacts with a living system to induce a physiological response
Most often drugs interact with natural macromolecules called receptors to produce these effects
4. Traditionally most drugs have been . However many newer drugs are, which
have a much larger structure.: small organic molecules; antibodies
5. What is a receptor: • A natural macromolecule which binds a drug to initiate the drug's effect.
•Most are proteins, but can sometimes be other macromolecules (e.g. large carbo- hydrates, etc.).
• A small number of drugs, including antiseptics and antacids produce their effects without specific receptor
interactions.
6. What are the broad receptor superfamilies: Ion channels G protein coupled
receptors
Tyrosine kinase receptors Steroid
hormone receptors
7. What are ion channels as drug receptors: Typically are cell membrane proteins that contain a pore, and when open
allows ions to move in or out of the cell
Drugs can bind to these receptors and either open or close the channel
8. Examples of drugs that interact with ion channels: Local anesthetics
1/
, Pharmacodynamics and Pharmacokinetics
Practise Questions And answers
9. What are G protein coupled receptors as drug receptors: Typically cell mem- brane proteins with seven
transmembrane segments
Indirectly activate or inhibit various enzymes using a member of the g-protein family as intermediaries
10.Examples of drugs that interact with G-protein coupled receptors: Vaso- constrictors
11.What are tyrosine kinases as drug receptors: Typically cell membrane pro- teins with a transmembrane
segment
Activation by drugs often leads to receptor dimerization and phosphorylation, fol- lowed by a receptor binding to various
signaling proteins to mediate a physiological effect
2/
