Induced Innate Immunity Chapter 3 Questions and Answers
3-1 C-type lectins are so called because of the role of _____ in facilitating receptor:ligand
interactions.
a. carbohydrate
b. CR1
c. calcium
d. chemokines
e. caspases ** Answ** c
3-2 Lectins recognize microbial _____.
a. phosphate-containing lipoteichoic acids
b. nucleic acids
c. carbohydrates
d. flagellin
e. sulfated polysaccharides ** Answ** c
3-3 Scavenger receptor SR-B recognizes _____.
a. lipopolysaccharides
b. teichoic acid
c. filamentous hemagglutinin
d. CpG-rich bacterial DNA
e. lipids ** Answ** e
3-4 Macrophages bear on their surface receptors for all of the following except _____. (Select all
that apply).
a. mannose
b. glucans
,c. C3b
d. muramyl dipeptide
e. lipopolysaccharide
f. lipoteichoic acid
g. CpG-rich bacterial DNA ** Answ** d and g
3-5 _____ is a soluble protein. (Select all that apply.)
a. TLR4
b. CD14
c. lipopolysaccharide-binding protein (LBP)
d. CXCR1
e. mannose-binding lectin ** Answ** c and e
3-6 _____ are structurally similar membrane-bound proteins that aid in the adhesion between
various types of human cell.
a. Interferons
b. Integrins
c. GTP-binding proteins
d. Pyrogens
e. Pentraxins ** Answ** b
3-7 All of the following induce fever except _____.
a. IL-12
b. IL-6
c. IL-1
d. TNF-\alpha ** Answ** a
, 3-9 Which of the following is not associated with mobilization of neutrophils to infected tissue?
a. TNF-\alpha production by macrophages
b. upregulation of selectins on blood vessel endothelium
c. interferon response
d. generation of a CXCL8 gradient
e. extravasation across endothelium
f. proteolysis of basement membrane of blood vessels ** Answ** c
3-10 Which of the following pairs is mismatched?
a. primary granules: azurophilic granules
b. secondary granules: unsaturated lactoferrin
c. azurophilic granules: myeloperoxidase
d. gelatinase: iron sequestration
e. tertiary granules: natural killer cells ** Answ** e
3-11 The pH of the phagosome increases following phagocytosis because _____.
a. the microbe delivers a significant number of hydroxyl ions in its cytosol that are released
upon membrane disruption
b. hydrogen ions are eliminated by the activity of NADPH oxidase and superoxide dismutase
c. azurophilic granules deliver alkaline substances
d. catalase consumes hydrogen ions once activated ** Answ** b
3-12 C-reactive protein binds to _____.
a. phosphorylcholine
b. mannose-containing carbohydrates
c. lipoteichoic acid
d. flagellin
3-1 C-type lectins are so called because of the role of _____ in facilitating receptor:ligand
interactions.
a. carbohydrate
b. CR1
c. calcium
d. chemokines
e. caspases ** Answ** c
3-2 Lectins recognize microbial _____.
a. phosphate-containing lipoteichoic acids
b. nucleic acids
c. carbohydrates
d. flagellin
e. sulfated polysaccharides ** Answ** c
3-3 Scavenger receptor SR-B recognizes _____.
a. lipopolysaccharides
b. teichoic acid
c. filamentous hemagglutinin
d. CpG-rich bacterial DNA
e. lipids ** Answ** e
3-4 Macrophages bear on their surface receptors for all of the following except _____. (Select all
that apply).
a. mannose
b. glucans
,c. C3b
d. muramyl dipeptide
e. lipopolysaccharide
f. lipoteichoic acid
g. CpG-rich bacterial DNA ** Answ** d and g
3-5 _____ is a soluble protein. (Select all that apply.)
a. TLR4
b. CD14
c. lipopolysaccharide-binding protein (LBP)
d. CXCR1
e. mannose-binding lectin ** Answ** c and e
3-6 _____ are structurally similar membrane-bound proteins that aid in the adhesion between
various types of human cell.
a. Interferons
b. Integrins
c. GTP-binding proteins
d. Pyrogens
e. Pentraxins ** Answ** b
3-7 All of the following induce fever except _____.
a. IL-12
b. IL-6
c. IL-1
d. TNF-\alpha ** Answ** a
, 3-9 Which of the following is not associated with mobilization of neutrophils to infected tissue?
a. TNF-\alpha production by macrophages
b. upregulation of selectins on blood vessel endothelium
c. interferon response
d. generation of a CXCL8 gradient
e. extravasation across endothelium
f. proteolysis of basement membrane of blood vessels ** Answ** c
3-10 Which of the following pairs is mismatched?
a. primary granules: azurophilic granules
b. secondary granules: unsaturated lactoferrin
c. azurophilic granules: myeloperoxidase
d. gelatinase: iron sequestration
e. tertiary granules: natural killer cells ** Answ** e
3-11 The pH of the phagosome increases following phagocytosis because _____.
a. the microbe delivers a significant number of hydroxyl ions in its cytosol that are released
upon membrane disruption
b. hydrogen ions are eliminated by the activity of NADPH oxidase and superoxide dismutase
c. azurophilic granules deliver alkaline substances
d. catalase consumes hydrogen ions once activated ** Answ** b
3-12 C-reactive protein binds to _____.
a. phosphorylcholine
b. mannose-containing carbohydrates
c. lipoteichoic acid
d. flagellin
