Allergy/Type-1 Hypersensitivity Questions and Answers
1. refers to diseases caused by an exaggerated im- mune response, regardless
whether the response is against a pathogen, non-pathogen, or self and regardless whether the response is
directed by antibodies, lymphocytes or innate pathways.: Hypersensitivity.
2. What is atopy?: Type I hypersensitivity, allergy, etc.
**means "strange disease."
3. What type of hypersensitivity reactions are autoimmune?: Type II-IV.
4. What is the theoretical basis for hypersensitivities?: - "Red Queen Hypothe- sis".
- Genetic diversity enables host organism to combat infection and as host evolves so does pathogen... each attempting
to evade defenses of the other.
5. What does multifactorial mean?: Multiple genes contribute to disease.
**Ex: ch 1, 2, 4, 5, 6, 7, 11, 13, 16 all have a gene that contributes to asthma.
6. Know:
Polymorphisms in IL-4 cause variation in .: Expression of IL-4.
7. Know:
Polymorphisms in IL-4 receptor alpha chain are
associated with .: Increased signaling in response to IL-4.
8. Know:
1/
, Allergy/Type-1 Hypersensitivity Questions and Answers
Polymorphisms in the high affinity IgE receptor B chain are associated with
.: Variation in consequences of IgE ligation by antigen
9. Know:
Polymorphisms in MHC class II genes cause enhanced presentation of
.: Particular allergen-derived peptides (ie: some people will gener- ate MHC's that present
allergens and some won't).
10.Which genetic polymorphism will have some people will generate MHC's that present allergens and some
won't: MHC class II genes
11. contributes to susceptibility.: Genetic polymorphisms.
**each person responds differently.
12.In western lifestyles there is a reduced incidence of common childhood infections which are dealt with by
. What is the consequence of this?: - Th1 cells.
2/
1. refers to diseases caused by an exaggerated im- mune response, regardless
whether the response is against a pathogen, non-pathogen, or self and regardless whether the response is
directed by antibodies, lymphocytes or innate pathways.: Hypersensitivity.
2. What is atopy?: Type I hypersensitivity, allergy, etc.
**means "strange disease."
3. What type of hypersensitivity reactions are autoimmune?: Type II-IV.
4. What is the theoretical basis for hypersensitivities?: - "Red Queen Hypothe- sis".
- Genetic diversity enables host organism to combat infection and as host evolves so does pathogen... each attempting
to evade defenses of the other.
5. What does multifactorial mean?: Multiple genes contribute to disease.
**Ex: ch 1, 2, 4, 5, 6, 7, 11, 13, 16 all have a gene that contributes to asthma.
6. Know:
Polymorphisms in IL-4 cause variation in .: Expression of IL-4.
7. Know:
Polymorphisms in IL-4 receptor alpha chain are
associated with .: Increased signaling in response to IL-4.
8. Know:
1/
, Allergy/Type-1 Hypersensitivity Questions and Answers
Polymorphisms in the high affinity IgE receptor B chain are associated with
.: Variation in consequences of IgE ligation by antigen
9. Know:
Polymorphisms in MHC class II genes cause enhanced presentation of
.: Particular allergen-derived peptides (ie: some people will gener- ate MHC's that present
allergens and some won't).
10.Which genetic polymorphism will have some people will generate MHC's that present allergens and some
won't: MHC class II genes
11. contributes to susceptibility.: Genetic polymorphisms.
**each person responds differently.
12.In western lifestyles there is a reduced incidence of common childhood infections which are dealt with by
. What is the consequence of this?: - Th1 cells.
2/
