NU 545 CH 9 EXAM QUESTIONS AND ANSWERS
WITH COMPLETE SOLUTIONS LATEST UPDATE
Hypersensitivity
Altered immunologic response to an antigen that results in disease or damage to the host
allergy
Deleterious effects of hypersensitivity to environmental antigens
Autoimmunity
Disturbance in the immunologic tolerance of self-antigens
Alloimmunity
Immune reaction to tissues of another individual
immunologic homeostasis
steady state of tolerance to self-antigens or lack of immune reaction against environmental antigens
Anaphylaxis
a severe response to an allergen in which the symptoms develop quickly, and without help, the patient
can die within a few minutes.
Type I IgE-Mediated Hypersensitivity
Mediated by antigen-specfic IgE and the products of tissue mast cells
, Cytotropic antibody
Antibody that binds to mast cells
Reagin
skin-sensitizing antibody
Type II: Tissue-specific Hypersensitivity Reactions
Characterized by a specific cell or tissue being the target of an immune response
Tissue specific antigens
Expressed on the plasma membranes in only certain cells in specific tissues
5 ways type II hypersensitivity reactions can affect cells
1)cell can be destroyed by antibody and activation of complement cascade through the classical pathway
2)antibody May cause cell destruction through phagocytosis by macrophages
3)antibody and complement may attract neutrophils
4)antibody-dependent cell-mediated cytotoxicity
5)does not destroy target cell, but causes it to malfunction
Antibody-dependent cell-mediated cytotoxicity
antibodies attached to target cell cause destruction by macrophages, eosinophils, and NK cells
Type III immune complex mediated hypersensitivity
Caused by antigen-antibody (immune) complexes that are formed in the circulation and deposited later
in vessel walls or extravascular tissues
Hypocomplementemia
WITH COMPLETE SOLUTIONS LATEST UPDATE
Hypersensitivity
Altered immunologic response to an antigen that results in disease or damage to the host
allergy
Deleterious effects of hypersensitivity to environmental antigens
Autoimmunity
Disturbance in the immunologic tolerance of self-antigens
Alloimmunity
Immune reaction to tissues of another individual
immunologic homeostasis
steady state of tolerance to self-antigens or lack of immune reaction against environmental antigens
Anaphylaxis
a severe response to an allergen in which the symptoms develop quickly, and without help, the patient
can die within a few minutes.
Type I IgE-Mediated Hypersensitivity
Mediated by antigen-specfic IgE and the products of tissue mast cells
, Cytotropic antibody
Antibody that binds to mast cells
Reagin
skin-sensitizing antibody
Type II: Tissue-specific Hypersensitivity Reactions
Characterized by a specific cell or tissue being the target of an immune response
Tissue specific antigens
Expressed on the plasma membranes in only certain cells in specific tissues
5 ways type II hypersensitivity reactions can affect cells
1)cell can be destroyed by antibody and activation of complement cascade through the classical pathway
2)antibody May cause cell destruction through phagocytosis by macrophages
3)antibody and complement may attract neutrophils
4)antibody-dependent cell-mediated cytotoxicity
5)does not destroy target cell, but causes it to malfunction
Antibody-dependent cell-mediated cytotoxicity
antibodies attached to target cell cause destruction by macrophages, eosinophils, and NK cells
Type III immune complex mediated hypersensitivity
Caused by antigen-antibody (immune) complexes that are formed in the circulation and deposited later
in vessel walls or extravascular tissues
Hypocomplementemia
