BASIC AND CLINICAL PHARMACOLOGY 14TH EDITION
KATZUNG TREVOR TEST BANK
Pharmacology - ANSWER: study of f the history, source, physical and chemical
properties, compounding, biochemical and physiological effect, mechanisms of
action, absorption, distribution, biotransformation and excretion, and therapeutic
and other uses of drugs
Drug - ANSWER: any chemical agent that when taken into a living organism may
modify one or more of its functions
Toxicology - ANSWER: study of poisonous substances and their effects upon body
parts
Pharmacokinetics - ANSWER: where drugs go, how long they stay, what chemical
changes occur, how they are removed; effect of body on a drug
Absorption - ANSWER: the movement of a drug from the site of administration to
bloodstream; intake of a drug into the system
Distribution - ANSWER: the transfer of a drug from one location to another within
the body; where the drug goes following absorption
Elimination - ANSWER: the removal of materials from the body; removal of a drug
Pharmacodynamics - ANSWER: what the drug does to the body; mechanism of action
systemic effects - ANSWER: generalized distribution of the chemical throughout the
body by the bloodstream to internal organs
Effect - ANSWER: the change in the organism caused by the chemical
Law of Mass Action - ANSWER: the rate of a chemical reaction is proportional to the
product of the activities or concentrations of the reactants
Response - ANSWER: is a function of the drug-receptor complex
ED50 - ANSWER: median effective dose; therapeutic effect; the dose required to
achieve 50% of desired response in 50% of the population
TD50 - ANSWER: median toxic dose; toxic effect; the dose required to get 50% of
population reporting this specific toxic effect
LD50 - ANSWER: median lethal dose; lethal effect; dose required to achieve 50%
mortality from toxicity
KATZUNG TREVOR TEST BANK
Pharmacology - ANSWER: study of f the history, source, physical and chemical
properties, compounding, biochemical and physiological effect, mechanisms of
action, absorption, distribution, biotransformation and excretion, and therapeutic
and other uses of drugs
Drug - ANSWER: any chemical agent that when taken into a living organism may
modify one or more of its functions
Toxicology - ANSWER: study of poisonous substances and their effects upon body
parts
Pharmacokinetics - ANSWER: where drugs go, how long they stay, what chemical
changes occur, how they are removed; effect of body on a drug
Absorption - ANSWER: the movement of a drug from the site of administration to
bloodstream; intake of a drug into the system
Distribution - ANSWER: the transfer of a drug from one location to another within
the body; where the drug goes following absorption
Elimination - ANSWER: the removal of materials from the body; removal of a drug
Pharmacodynamics - ANSWER: what the drug does to the body; mechanism of action
systemic effects - ANSWER: generalized distribution of the chemical throughout the
body by the bloodstream to internal organs
Effect - ANSWER: the change in the organism caused by the chemical
Law of Mass Action - ANSWER: the rate of a chemical reaction is proportional to the
product of the activities or concentrations of the reactants
Response - ANSWER: is a function of the drug-receptor complex
ED50 - ANSWER: median effective dose; therapeutic effect; the dose required to
achieve 50% of desired response in 50% of the population
TD50 - ANSWER: median toxic dose; toxic effect; the dose required to get 50% of
population reporting this specific toxic effect
LD50 - ANSWER: median lethal dose; lethal effect; dose required to achieve 50%
mortality from toxicity
