2024 ONCOLOGY NAPLEX REVIEW
EXAM WITH CORRECT ANSWERS
anti-emetic regimen for highly emetogenic chemotherapy - CORRECT-
ANSWERSfosapretant + dexmethasone +
ondansetron + olanzapine
3 or 4 drug regimen
NK1-RA + 5HT3- RA + dexmethasone + olanzapine
What therapies are available for tumor lysis syndrome? - CORRECT-
ANSWERSAllopurinol (+/- Rasburicase)
What is a common concern (adverse effect) associated with Irinotecan? What
are recommended treatments based on timing? - CORRECT-ANSWERS1.
Acute diarrhea; Treatment: atropine
2. Delayed diarrhea; Treatment: loperamide
What chemotherapy drug is mesna (Mesnex) given with to prevent
hemorrhagic cystitis? - CORRECT-ANSWERSIfosfamide
Which 3 chemotherapy drug classes are cell cycle independent?
(List drug class and at least 1-agent in each class) - CORRECT-ANSWERS1.
Alkylating Agents (cyclophosphamide, ifosfamide, carmustine, busulfan, etc.)
2. Platinum-based compounds (cisplatin, carboplatin, oxaliplatin)
3. Anthracyclines (doxorubicin, daunorubicin, mitoxantrone)
Why is leucovorin given with methotrexate?
fluorouricil? - CORRECT-ANSWERSto decrease toxicities of MTX
(also to enhance efficacy of 5-FU)- co factor
adjunctive therapy with ifosfamide? - CORRECT-ANSWERSMESNA (Mesnex) to
prevent hemorrhagic cystitis
only initiate ESAs when Hgb is ???
BBW of ESAs? - CORRECT-ANSWERSONLY when hbg is <10 g/dL
, BBW: shorten survival and increased tumor progression
Delayed Chemotherapy Induced Nausea-Vomiting - CORRECT-ANSWERS> 24
hours AFTER chemo
treatment for "anticipatory" N/V with chemo?? - CORRECT-ANSWERSBZDs
ex. lorazepam
-start the evening PRIOR to chemo to allieviate N/V and anxiety
Sancuso (patch) - CORRECT-ANSWERSgranisetron
5HT 3 receptor antagonist (blocks serotonin)
antiemetic
Aloxi - CORRECT-ANSWERSPalonsetron
5HT 3 receptor antagonist (blocks serotonin)
antiemetic
Emend IV - CORRECT-ANSWERSFosaprepitant (NK1-RA)
antiemetic
Emend (oral)
-capsule, suspension, injection - CORRECT-ANSWERSAprepitant (NK1-RA)
antiemetic
Marinol - CORRECT-ANSWERSDronabinol
capsules= CIII
suspension= CII
appetite stimulant, euphoria, somnolence
(cannabinoid)
Cesamet - CORRECT-ANSWERSNabilone
CII
appetite stimulant, euphoria, somnolence
(cannabinoid)
cancer meds that commonly cause diarrea? - CORRECT-ANSWERSireotecan
fluorouracil
capecitabine
EXAM WITH CORRECT ANSWERS
anti-emetic regimen for highly emetogenic chemotherapy - CORRECT-
ANSWERSfosapretant + dexmethasone +
ondansetron + olanzapine
3 or 4 drug regimen
NK1-RA + 5HT3- RA + dexmethasone + olanzapine
What therapies are available for tumor lysis syndrome? - CORRECT-
ANSWERSAllopurinol (+/- Rasburicase)
What is a common concern (adverse effect) associated with Irinotecan? What
are recommended treatments based on timing? - CORRECT-ANSWERS1.
Acute diarrhea; Treatment: atropine
2. Delayed diarrhea; Treatment: loperamide
What chemotherapy drug is mesna (Mesnex) given with to prevent
hemorrhagic cystitis? - CORRECT-ANSWERSIfosfamide
Which 3 chemotherapy drug classes are cell cycle independent?
(List drug class and at least 1-agent in each class) - CORRECT-ANSWERS1.
Alkylating Agents (cyclophosphamide, ifosfamide, carmustine, busulfan, etc.)
2. Platinum-based compounds (cisplatin, carboplatin, oxaliplatin)
3. Anthracyclines (doxorubicin, daunorubicin, mitoxantrone)
Why is leucovorin given with methotrexate?
fluorouricil? - CORRECT-ANSWERSto decrease toxicities of MTX
(also to enhance efficacy of 5-FU)- co factor
adjunctive therapy with ifosfamide? - CORRECT-ANSWERSMESNA (Mesnex) to
prevent hemorrhagic cystitis
only initiate ESAs when Hgb is ???
BBW of ESAs? - CORRECT-ANSWERSONLY when hbg is <10 g/dL
, BBW: shorten survival and increased tumor progression
Delayed Chemotherapy Induced Nausea-Vomiting - CORRECT-ANSWERS> 24
hours AFTER chemo
treatment for "anticipatory" N/V with chemo?? - CORRECT-ANSWERSBZDs
ex. lorazepam
-start the evening PRIOR to chemo to allieviate N/V and anxiety
Sancuso (patch) - CORRECT-ANSWERSgranisetron
5HT 3 receptor antagonist (blocks serotonin)
antiemetic
Aloxi - CORRECT-ANSWERSPalonsetron
5HT 3 receptor antagonist (blocks serotonin)
antiemetic
Emend IV - CORRECT-ANSWERSFosaprepitant (NK1-RA)
antiemetic
Emend (oral)
-capsule, suspension, injection - CORRECT-ANSWERSAprepitant (NK1-RA)
antiemetic
Marinol - CORRECT-ANSWERSDronabinol
capsules= CIII
suspension= CII
appetite stimulant, euphoria, somnolence
(cannabinoid)
Cesamet - CORRECT-ANSWERSNabilone
CII
appetite stimulant, euphoria, somnolence
(cannabinoid)
cancer meds that commonly cause diarrea? - CORRECT-ANSWERSireotecan
fluorouracil
capecitabine
