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dose-response curve
Plot of data showing effects of various doses of a toxic agent on a group of test organisms.
Different types of research designs used in epidemiological research
individual data, randomized design, non-randomized design, before - after design, & formative program
evaluation
Koch's Postulates
In 1890 the German physician and bacteriologist Robert Koch set out his celebrated criteria for judging
whether a given bacteria is the cause of a given disease. Koch's criteria brought some much-needed
scientific clarity to what was then a very confused field.
Koch's postulates are as follows:
The bacteria must be present in every case of the disease.
The bacteria must be isolated from the host with the disease and grown in pure culture.
The specific disease must be reproduced when a pure culture of the bacteria is inoculated into a healthy
susceptible host.
The bacteria must be recoverable from the experimentally infected host.
, Disease causation
the risk factors for disease development and their relative strength with respect to an individual and
population
Population attributable risk
(Syn: population risk difference) The incidence of a disease in a population that is associated with
(attributable to) exposure to the risk factor. It is often expressed as a percentage (i.e., population
attributable risk percent, population etiologic fraction).
efficacy
a measure in a situation
in which all conditions are controlled to maximize
the effect of the agent
Effect modification
is present when the effect of the main exposure on the outcome is modified by the presence of another
variable
Effectiveness
If we administer the agent in a "real-life" situation,
is it effective?
Efficiency
If an agent is shown to be effective, what is the cost-benefit
ratio?
Research designs to explore relationships