Faculty of Medicine & Health Sciences Semester 3 Pathology Course P3 Cellular Adaptations in Disease Prof. James Lowe 5th October 1999 Cellular adaptations in disease Overview  Adaptability of cells to an altered environment  Physiological

Faculty of Medicine & Health Sciences Semester 3 Pathology Course P3 Cellular Adaptations in Disease Prof. James Lowe 5th October 1999 Cellular adaptations in disease Overview  Adaptability of cells to an altered environment  Physiological and pathological stimuli  Changes in growth pattern  Hyperplasia, hypertrophy, atrophy, involution, metaplasia  Apoptosis  Growth factors  Role in altered environment Faculty of Medicine & Health Sciences, October 1999 Cellular adaptations in disease Why is this important?  Extremely common responses in disease  Certain adaptations in growth act as a fertile ground for the later development of neoplasia cancer formation…  Nomenclature is used in clinical work. Faculty of Medicine & Health Sciences, October 1999 Cellular adaptations in disease Adaptability of cells to an altered environment  Cells are constantly exposed to changes in their environment  Cells can adapt to acceptable changes in their environment by modifying metabolism or growth pattern  Environmental changes can be physiological or pathological Faculty of Medicine & Health Sciences, October 1999 Cellular adaptations in disease Examples of pathological stimuli  Nutritional  Immune  Endocrine  Physical agents  Chemical agents  Infections  Anoxia  Genetic Faculty of Medicine & Health Sciences, October 199